text:
I'll Name the Dogs
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"I'll Name the Dogs"
Single by Blake Shelton
from the album Texoma Shore
Released
September 11, 2017 (2017-09-11)
Format
Digital download
Genre
Country
Length
3:03
Label
Warner Bros. Nashville
Songwriter(s)
Matt Dragstrem
Ben Hayslip
Josh Thompson
Producer(s)
Scott Hendricks
Blake Shelton singles chronology
"Every Time I Hear That Song"
(2017) "I'll Name the Dogs"
(2017) "You Make It Feel Like Christmas"
(2017)
"Every Time I Hear That Song"
(2017) "I'll Name the Dogs"
(2017) "You Make It Feel Like Christmas"
(2017)
Music video
I'll Name the Dogs on YouTube
"I'll Name the Dogs" is a song recorded by American country music artist Blake Shelton for his eleventh studio album, Texoma Shore (2017). Released to radio as the album's first single on September 11, 2017, the track was written by Matt Dragstrem, Ben Hayslip and Josh Thompson, while production was handled by Scott Hendricks.
Contents
[hide]
1 Background and composition
2 Commercial performance
3 Charts
4 Certifications
5 References
Background and composition[edit]
"I'll Name the Dogs" was written by Matt Dragstrem, Ben Hayslip and Josh Thompson, while production was handled by Scott Hendricks.
Commercial performance[edit]
The song first entered the Billboard Country Airplay chart at No. 23 on the issue date of September 28, 2017,[1] and Hot Country Songs at No. 40 the same week.[2] It became available for sale the following week, and was the second best-selling country song that week with 27,273 copies sold, helping the song move to No. 10 on the Hot Country Songs chart.[3] The song has sold 185,000 copies in the United States as of January 2018.[4]
Charts[edit]
Chart (2017–18)
Peak
position
Canada (Canadian Hot 100)[5]
78
Canada Country (Billboard)[6]
1
US Billboard Hot 100[7]
56
US Country Airplay (Billboard)[8]
1
US Hot Country Songs (Billboard)[9]
6
Certifications[edit]
Region
Certification
Certified units/Sales
Canada (Music Canada)[10]
Gold 40,000^
^shipments figures based on certification alone
References[edit]
Jump up ^ "Country Airplay". Billboard. September 23, 2017.
Jump up ^ "Country Songs". Billboard. September 23, 2017.
Jump up ^ Asker, Jim (September 19, 2017). "Thomas Rhett on Being First Country Act to Top Billboard 200 This Year: 'It Blows My Mind'". Billboard.
Jump up ^ Bjorke, Matt (January 9, 2018). "Top 30 Digital Country Singles Sales Chart: January 9, 2018". Roughstock. Retrieved February 11, 2018.
Jump up ^ "Blake Shelton Chart History (Canadian Hot 100)". Billboard. Retrieved September 22, 2017.
Jump up ^ "Blake Shelton Chart History (Canada Country)". Billboard. Retrieved November 28, 2017.
Jump up ^ "Blake Shelton Chart History (Hot 100)". Billboard. Retrieved January 9, 2018.
Jump up ^ "Blake Shelton Chart History (Country Airplay)". Billboard. Retrieved December 19, 2017.
Jump up ^ "Blake Shelton Chart History (Hot Country Songs)". Billboard. Retrieved November 14, 2017.
Jump up ^ "Canadian single certifications – Blake Shelton – I'll Name the Dogs". Music Canada. Retrieved January 10, 2018.
Preceded by
"Every Little Thing"
by Carly Pearce Billboard Canada Country
number-one single
December 9–23, 2017 Succeeded by
"Like I Loved You"
by Brett Young
Preceded by
"Light It Up"
by Luke Bryan Billboard Country Airplay
number-one single
December 30, 2017
[hide]
v
t
e
Blake Shelton singles
Discography
Blake Shelton
"Austin"
"All Over Me"
"Ol' Red"
The Dreamer
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"Heavy Liftin'"
"Playboys of the Southwestern World"
Blake Shelton's Barn & Grill
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Based on a True Story...
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"Came Here to Forget"
"A Guy with a Girl"
"Go Ahead and Break My Heart"
"Friends"
"Savior's Shadow"
"Every Time I Hear That Song"
Texoma Shore
"I'll Name the Dogs"
"I Lived It"
Collaborations
"The Truth About Men"
"Just a Fool"
"Medicine"
"You Make It Feel Like Christmas"
Other songs
"Hillbilly Bone"
"All About Tonight"
"Who Are You When I'm Not Looking"
"Footloose"
"Over You"
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text:
I Don't Feel at Home in This World Anymore
From Wikipedia, the free encyclopedia
Jump to: navigation, search
I Don't Feel at Home in This World Anymore
Film poster
Directed by
Macon Blair
Produced by
Mette-Marie Kongsved
Neil Kopp
Vincent Savino
Anish Savjani
Written by
Macon Blair
Starring
Melanie Lynskey
Elijah Wood
David Yow
Jane Levy
Devon Graye
Music by
Brooke Blair
Will Blair
Cinematography
Larkin Seiple
Edited by
Tomas Vengris
Production
company
Film Science
XYZ Films
Distributed by
Netflix
Release date
January 19, 2017 (2017-01-19) (Sundance Film Festival)
February 24, 2017 (2017-02-24) (United States)
Running time
96 minutes[1]
Country
United States
Language
English
I Don't Feel at Home in This World Anymore (often stylized I don't feel at home in this world anymore.) is a 2017 American comedy thriller film written and directed by Macon Blair in his directorial debut. It stars Melanie Lynskey, Elijah Wood, David Yow, Jane Levy and Devon Graye.
The film had its world premiere at the Sundance Film Festival on January 19, 2017; it went on to win the Grand Jury Prize for the U.S. Dramatic competition.[2] It was released by Netflix on 24 February 2017.
Contents
[hide]
1 Plot
2 Cast
3 Production
3.1 Filming
4 Release
4.1 Critical reception
4.2 Accolades
5 References
6 External links
Plot[edit]
This section's plot summary may be too long or excessively detailed. Please help improve it by removing unnecessary details and making it more concise. (April 2017) (Learn how and when to remove this template message)
Ruth, a nursing assistant, has a bad start to her day when one of her patients dies. When she returns home, she realizes she has been burgled. She reports to the police that the thief has stolen anti-depressants and anti-anxiety medication along with her grandmother's silverware and a laptop. When she asks Detective William Bendix for advice, he chastises her for leaving her door unlocked.
Convinced the police will be of no help, she goes door to door, asking her neighbors if they saw anything suspicious. One of them, Tony, a heavy metal fan, becomes enraged that someone would target a neighbor. Frightened by his reaction, Ruth leaves; however, later, she returns to seek his help after the police refuse to follow up on a mobile app revealing the location of her laptop.
Ruth and Tony go to the location, where a man accidentally knocks himself out in a confrontation with Tony's martial arts weapon and Ruth intimidates the owner into returning her laptop. He reveals he bought it from a fence who operates a resale shop. After getting the shop's address, Ruth and Tony celebrate their victory by getting drunk and dancing. Investigating further the next morning, Ruth finds her grandmother's silverware and a man whose shoe matches a print left in her yard. Ruth gets into a scuffle with the fence when he demands she pay for the stolen silverware. After he breaks her finger, Tony knocks him unconscious, and they flee.
After Ruth becomes frustrated that she was not able to confront the youth she suspects to be the burglar, Tony reveals that he caught the license plate number on the van he rode away in. Tony researches the tag number of the van online, revealing the owner of the van and possible thief as Christian Rumack. Ruth takes all her evidence to Bendix, but he scolds her for investigating her case without police assistance. Though he warns that she will endanger herself further if she continues to engage in vigilantism, Ruth and Tony impersonate cops at the address linked to the tag on the thief's getaway van. A woman named Meredith lets them inside her mansion and answers their questions regarding Christian Rumack and the van. She reveals that the owner of the van, her husband Chris, is not the one who uses the van; it is instead her step-son, who was given the van by his father. She says Christian became disowned by his father after being jailed for drug-related offenses and befriending criminals he met there. Chris senior returns home abruptly with his bodyguard and angrily questions Meredith's intelligence for allowing Ruth and Tony inside, as they are obviously not cops.
As Chris' bodyguard holds them at gunpoint, Chris wearily offers to pay them off. He is confused when Ruth refuses his money, and she says she merely wants to confront Christian about his behavior. Chris taunts her for her idealism, and, as they leave, Ruth vandalizes his lawn art, stealing a sculpture, to which Tony protests. Christian and his friends, Marshall and Dez, watch from the side, calling off their intended robbery of Chris and instead send Christian to confront Ruth about what she knows about them. He surprises her inside her home, and she crushes his windpipe in defense. As he staggers into the street, a bus strikes and kills him. Marshall and Dez kidnap Ruth, forcing her to take Christian's place in their heist.
Armed with an empty pistol, Ruth gains them entry into the mansion. Meredith and Cesar are held at gunpoint and told to summon Chris. Dez shoots Chris in the hand after he comes downstairs; his gruesome injury causes Ruth to vomit, and she drops her gun. Cesar grabs it, and attempts to shoot Marshall, who fires back at him. As the two fight, Cesar pulls off Marshall's mask, but is shot in the neck and dies. Marshall demands that Chris open the safe hidden in the fireplace that Christian told them about. Marshall opens it to find that there is no cash inside, only documents, and in the moment of calm Ruth protests that she is a hostage, using her unloaded gun as proof. She is ignored, and Marshall and Dez proclaim that they are "done here".
Dez raises her gun to kill Meredith, but Ruth steps in front of her. Tony arrives, stolen lawn sculpture in hand, and strikes Dez in the face with a ninja star. When Dez tries to fire her gun at Tony, it backfires and explodes, blowing her hand off. Chris takes the opportunity to try to steal Marshall's gun, but Marshall accidentally shoots him through the head, killing him. Marshall points his gun at Tony next, but Ruth wrestles him to the ground. Dez stabs Tony several times in the stomach and then advances on Ruth. Marshall's gun goes off as Ruth tears at his hand with her teeth, and a stray bullet strikes Dez in the head, killing her. Ruth gains the upper hand over Marshall, bludgeoning him in the head and leg with the butt of his own gun, and helps Tony flee into the forest behind the mansion. Marshall recovers and chases them as Meredith flees the mansion unnoticed and alone.
Ruth hides Tony under some brush, as he can no longer walk due to his wounds, and continues to run from Marshall. After a long chase and confrontation, Ruth attacks Marshall by throwing rocks at him, and his sudden movements cause him to be bitten by a water moccasin that Ruth had avoided earlier. Ruth leaves him to die from his wounds. Panicked that she cannot find Tony on her way back, Ruth sees her grandmother's ghost point her in the correct direction. Grateful that Ruth saved her life, Meredith neglects to identify her as one of the burglars to Bendix. Ruth returns to her daily life with Tony, who survives his wounds, and she joins his church.
Cast[edit]
Melanie Lynskey as Ruth Kimke
Elijah Wood as Tony
David Yow as Marshall
Jane Levy as Dez
Devon Graye as Christian Rumack, Jr.
Christine Woods as Meredith
Robert Longstreet as Christian Rumack
Gary Anthony Williams as William Bendix
Lee Eddy as Angie
Derek Mears as Donkey
Jason Manuel Olazabal as Cesar
Maxwell Hamilton as Smoker
Matt Orduna as Dan
Michelle Moreno as Jana Huff
Jeb Berrier as Gearhead
Writer and director Macon Blair makes a cameo appearance as a man Ruth meets at a bar. The movie is dedicated "For Lee & Buck." (Lee Eddy who played Angie & Buck Eddy-Blair who played young Ruth)
Production[edit]
In April 2016, it was announced Melanie Lynskey and Elijah Wood had been cast in the film, with Macon Blair writing and directing the film.[3][4][5]
Filming[edit]
Principal photography began in April 2016, in Portland, Oregon.[6][7]
Release[edit]
The film had its world premiere at the Sundance Film Festival on January 19, 2017.[8] It received a worldwide release on February 24, 2017, streaming exclusively on Netflix.[9]
Critical reception[edit]
I Don't Feel At Home in This World Anymore received positive reviews from film critics. It currently holds an 88% "fresh" rating on review aggregator Rotten Tomatoes, based on 51 reviews, with an average score of 7.4/10. The site's critical consensus reads, "I Don't Feel At Home In This World Anymore transcends its unwieldy title to offer timely, intoxicatingly dark observations on gender dynamics and social norms in modern America."[10] On Metacritic, the film has a 75 out of 100 rating, based on 15 reviews, indicating "generally favorable reviews".[11]
Accolades[edit]
Award
Date of ceremony
Category
Recipient(s) and nominee(s)
Result
Ref.
Gotham Independent Film Awards November 27, 2017 Best Actress Melanie Lynskey Pending [12]
References[edit]
Jump up ^ "Printable Film Guide" (PDF). Sundance Film Festival. Retrieved December 15, 2016.
Jump up ^ "2017 Sundance Film Festival Award Winners" (PDF). Sundance Film Festival Official Site. Sundance Organization. Retrieved 31 January 2017.
Jump up ^ Schmidlin, Charlie (April 15, 2016). "Elijah Wood on What It's Like to Work with Nicolas Cage on 'The Trust'". Vice. Retrieved December 15, 2016.
Jump up ^ "Macon Blair". Digesis Magazine. May 3, 2016. Retrieved December 15, 2016.
Jump up ^ "Macon Blair". Filmmaker Magazine. Retrieved December 15, 2016.
Jump up ^ Turnquist, Kristi (April 12, 2016). "Elijah Wood's in Portland -- where should he visit?". Oregon Live. Retrieved December 15, 2016.
Jump up ^ Spitz, Enid (April 14, 2016). "The New Elijah Wood Movie Is Filming in NoPo Tonight". wweek.com. Retrieved December 15, 2016.
Jump up ^ Patten, Dominic (December 5, 2016). "Sundance 2017: Robert Redford, New Rashida Jones Netflix Series, 'Rebel In The Rye' & More On Premiere, Docu, Midnight & Kids Slates". Deadline.com. Retrieved December 15, 2016.
Jump up ^ "Netflix Announces Slate of Original Films, Documentaries and Series at the 2017 Sundance Film Festival". The Futon Critic. December 5, 2016. Retrieved December 14, 2016.
Jump up ^ "I Don't Feel at Home in This World Anymore". Rotten Tomatoes. Retrieved August 28, 2017.
Jump up ^ "i don't feel at home in this world anymore. Reviews". Metacritic. Retrieved August 28, 2017.
Jump up ^ Erbland, Kate (19 October 2017). "'Get Out' Leads 2017 Gotham Awards Nominations". IndieWire. Retrieved 19 October 2017.
External links[edit]
I Don't Feel at Home in This World Anymore on IMDb
I Don't Feel at Home in This World Anymore at Rotten Tomatoes
Awards
Preceded by
The Birth of a Nation Sundance Grand Jury Prize: U.S. Dramatic
2017 Most recent
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When Calls the Heart
From Wikipedia, the free encyclopedia
Jump to: navigation, search
Not to be confused with When the Heart Calls.
When Calls the Heart
Genre
Family Drama
Western
Based on
When Calls the Heart
by Janette Oke
Developed by
Michael Landon Jr.
Starring
Erin Krakow
Daniel Lissing
Lori Loughlin
Martin Cummins
Jack Wagner
Pascale Hutton
Kavan Smith
Country of origin
Canada
United States
Original language(s)
English
No. of seasons
5
No. of episodes
50 (list of episodes)
Production
Executive producer(s)
Michael Landon Jr.
Jimmy Townsend
Roman Viaris
Francisco Gonzalez
Brian Bird
Brad Krevoy
Producer(s)
Vicki Sotheran
Greg Malcolm
Location(s)
Vancouver, British Columbia, Canada
Running time
42–84 minutes
Production company(s)
Believe Pictures
Brad Krevoy Television
Jordan Films
Release
Original network
Hallmark Channel (U.S.)
Super Channel (Canada)
Picture format
480i (SDTV)
1080i (HDTV)
Original release
January 11, 2014 (2014-01-11) – present (present)
External links
Website
When Calls the Heart is a Canadian-American television drama series, inspired by Janette Oke's book of the same name from her Canadian West series, and developed by Michael Landon Jr. The series began airing on the Hallmark Channel in the United States on January 11, 2014,[1] and on April 16, 2014 on Super Channel in Canada.[2]
The series originally debuted as a two-hour television movie pilot in October 2013, starring Maggie Grace as young teacher Elizabeth Thatcher and Stephen Amell as North West Mounted Police officer Wynn Delaney.[3] In the television series Erin Krakow is cast as her niece, whose name is also Elizabeth Thatcher (played by Poppy Drayton in the movie[4]), and Daniel Lissing plays a Mountie named Jack Thornton, with Lori Loughlin reprising her role as coal mine widow Abigail Stanton.[1][5]
On April 24, 2017, Krakow announced via the Hallmark Channel website that the show would return for a fifth season,[6] which premiered with a two-hour Christmas special broadcast as part of Hallmark's Countdown to Christmas event and resumed in February 2018, ending in April.[7] On March 21, 2018, Hallmark renewed the series for a sixth season.[8]
Contents
[hide]
1 Plot
2 Episodes
3 Cast
3.1 Main
3.2 Recurring
4 Characters
5 Production
6 Broadcast
7 References
8 External links
Plot[edit]
When Calls the Heart tells the story of Elizabeth Thatcher (Erin Krakow), a young teacher accustomed to her high-society life. She receives her first classroom assignment in Coal Valley, a small coal-mining town in Western Canada which is located just south of Robb, Alberta. There, life is simple—but often fraught with challenges. Elizabeth charms most everyone in Coal Valley, except Royal North West Mounted Police Constable Jack Thornton (Daniel Lissing). He believes Thatcher’s wealthy father has doomed the lawman's career by insisting he be assigned in town to protect the shipping magnate’s daughter. The town of Coal Valley was renamed Hope Valley in Episode 2, Season 2 after the coal mine was closed.
Living in this 1910 coal town, Elizabeth must learn the ways of the Canadian frontier movement if she wishes to thrive in the rural west on her own. Lori Loughlin portrays Abigail Stanton, whose husband, the foreman of the mine, and her only son—along with 45 other miners—have recently been killed in an explosion, which turns out to have been a tragic accident waiting to happen—a result of the mining-company site manager's irresponsible management and lack of due care in his management of the mine. The newly widowed women find their faith tested when they must go to work in the mine to keep a roof over their heads, food on the table, and compile a wage for the town's teacher.[9]
Episodes[edit]
Main article: List of When Calls the Heart episodes
Season
Episodes
Originally aired
First aired
Last aired
1 12 January 11, 2014 (2014-01-11) March 29, 2014 (2014-03-29)
2 7 April 25, 2015 (2015-04-25) June 13, 2015 (2015-06-13)
New Year's Wish December 26, 2015 (2015-12-26)
3 8 February 21, 2016 (2016-02-21) April 10, 2016 (2016-04-10)
Christmas December 25, 2016 (2016-12-25)
4 10 February 19, 2017 (2017-02-19) April 23, 2017 (2017-04-23)
The Christmas Wishing Tree December 25, 2017 (2017-12-25)
5 10 February 18, 2018 (2018-02-18) April 22, 2018 (2018-04-22)
Cast[edit]
Main[edit]
Erin Krakow as Elizabeth Thatcher Thornton
Daniel Lissing as Jack Thornton (Seasons 1-5)
Lori Loughlin as Abigail Stanton
Jack Wagner as Bill Avery
Martin Cummins as Henry Gowen
Pascale Hutton as Rosemary LeVeaux Coulter
Kavan Smith as Leland Coulter
Recurring[edit]
Paul Greene as Carson Shepherd
Gracyn Shinyei as Emily Montgomery
Loretta Walsh as Florence Blakeley
Erica Carroll as Dottie Ramsey
Mark Humphrey as Frank Hogan
Johannah Newmarch as Molly Sullivan
Mitchell Kummen as Gabe Montgomery
Logan Williams as Miles Montgomery
Ben Rosenbaum as Hickam
Carter Ryan Evancic as Cody Hastings
Chelah Horsdal as Cat Montgomery
Steve Bacic as Charles Spurlock
Kristina Wagner as Nora Avery
Aren Buchholz as Jesse Flynn
Charlotte Hegele as Julie Thatcher
Andrea Brooks as Faith Carter
Eva Bourne as Clara Stanton
Ava Grace Cooper as Opal
Max Lloyd-Jones as Tom Thornton
Brooke Shields as Charlotte Thornton
Devon Weigel as Viola Thatcher
Marcus Rosner as Charles Kensington
Mamie Laverock as Rosaleen Sullivan
Adrian Hough as Reverend Anderson
Lynda Boyd as Grace Thatcher
Will Verchere-Gopaulsingh as Caleb Dunbar
Ali Skovbye as Becky Hastings
Garwin Sanford as William Thatcher
Laura Bertram as Mary Dunbar
Derek Hamilton as Dewitt Graves
Niall Matter as Shane Cantrell (season 4)
Spencer Drever as Cyrus Rivera (season 4)
Josie Bissett as AJ Foster
Characters[edit]
This section may contain an excessive amount of intricate detail that may only interest a specific audience. Please help by spinning off or relocating any relevant information, and removing excessive detail that may be against Wikipedia's inclusion policy. (April 2018) (Learn how and when to remove this template message)
Elizabeth Thatcher Thornton is an independent, strong-minded, passionate and dedicated young teacher from the city. The middle daughter of William and Grace Thatcher, Elizabeth has two sisters, older sister Viola and younger sister Julie. Elizabeth finds herself in Coal Valley, a small community on the Canadian frontier in need of a teacher, and quickly discovers it is not an easy place to live, lacking the creature comforts and luxuries of her privileged life with her family. She soon meets the newly appointed and charismatic Mountie Jack Thornton and develops an immediate dislike for him. However, over time they become good friends, and develop an obvious attraction to one another. In the final episode of season 1, "Prelude to a Kiss," (also titled as "Final Adieu"), after overcoming many obstacles throughout the season, Jack tells Elizabeth, "You're the one, you're the only one" and they share a kiss. Throughout season 2, Elizabeth's feelings for Jack are high at times as well as low. Finally, in the season 2 finale, she admits that his job as a Mountie scares her. After being comforted both admitting that they love each other, Jack and Elizabeth kiss.
Jack Thornton is a laid back country boy. Jack is the son of Mountie Thomas Thornton and his wife Charlotte Thornton. Jack has a younger brother, Tom (named after his father). As a Mountie and a man of stout character and integrity, he often finds himself protecting and saving people. In season 1's "A Telling Silence," Jack finds a basset hound whom he names Rip (after Rip Van Winkle) and takes home with him. A source of comfort and companion in the small town, Jack often goes to Rip when times in his life are difficult. In season 2's "With All My Heart," Rip, who's afraid of thunder, hides in the mine shafts during a storm. Jack and Elizabeth search for him; in their search, their relationship grows stronger. Upon his first meeting of Elizabeth, he developed an instant dislike and it appeared she irritated him. However, he grew to like and then fall madly and completely in love with her over time. In "Rules of Engagement" (S.1), it is revealed that Jack was briefly engaged to Rosemary LeVeaux when she comes looking for him. However, they have both changed and realize that they cannot have a relationship as they once did ever again. In "Prelude to a Kiss" (S.1), Jack found out that Elizabeth may be leaving Coal Valley. Taking her on a walk and giving her a framed picture of them that he had sketched, he asks her not to leave Coal Valley and tells her, "You're the one, you're the only one." She replied that she was "not going anywhere", Coal Valley was where she belonged before they share a kiss. In season 2, Elizabeth and Jack share a hot-and-cold relationship until the finale, "With All My Heart." They both admit that they love each other and share another kiss. Jack's brother, Tom, is introduced season 2's "Trials of the Heart," and their rocky relationship continues until "Coming Together, Coming Apart." Jack gently reminds his younger brother how their father was so proud of him, but he wouldn't be proud of the way he was currently living. Both in tears, Jack tells his younger brother that he believes in him and that he can turn his life around. More recently, Jack has become good friends with the sawmill operator, Lee Coulter. In season 3, Jack begins the new year knowing that Elizabeth only has eyes for him and that her relationship with Charles is over for good. In "Hearts In Question," Jack's mother Charlotte shows up unexpectedly. She meets Elizabeth and is suspicious of her, but through staying her sees Elizabeth for who she really is: a trustworthy, dedicated teacher. In the season finale, "Prayers From The Heart," Jack is injured in a flood. But he miraculously recovers in time to serve as Lee's best man at his wedding.
Abigail Stanton is a Coal Valley woman who tragically lost her husband and son in the mining accident. Abigail is a very kind woman, and she stands strongly for the things she believes in. She is one of the first women to welcome Elizabeth and the two women quickly become friends. When Elizabeth accidentally burns down the little teacherage, Abigail gladly welcomes her into her home to live. After being complimented on her cooking, Abigail decides to open a cafe in Coal Valley. Together, Abigail and Elizabeth move into the rooms above the cafe. At the end of season 1, Abigail enjoys the company of Bill Avery, a Mountie, serving as a Forensic Investigator and friend of Jack Thornton's. In season 2, Abigail takes in her daughter-in-law, Clara, the wife of her late son Peter whom Abigail sees as the daughter she never had. With Bill's past being revealed, Abigail ends their friendship and spends more time with the new pastor, Frank Hogan. Also, she is a strong independent woman that is set on doing the things that are right and tries to help Elizabeth.
Bill Avery is a mysterious, quiet man. He first appears in season 1's "Rules of Engagement," in order to help Jack expose Mr. Gowen's wrongdoings. Bill is immediately attracted to widow Abigail Stanton. Things are going well until Abigail discovers a picture of Bill's family and his wedding ring. He later tells her that his son died, as well as his wife. However, his wife, Nora, comes to confront him in season 2's "Heart's Desire."
Henry Gowen is a cold, cynical man who formerly owned the coal mine. After the mine was shut down, Henry became the mayor of Hope Valley and still creates a cold, cynical presence whenever people are around him. Henry is highly disliked and feared in the town. He frequently uses bribery to get what he wants, which is never for the good of the town.
Rosemary "Rosie" LeVeaux Coulter is a flamboyant, enthusiastic actress from New York. She was briefly engaged to Jack Thornton, but they both realized that it wouldn't work out. Rosie immediately disliked Elizabeth and viewed her as "the competition," but eventually came to really care about Elizabeth, even if she has a hard time showing it. At the beginning of season 2, Rosemary began working at the cafe with Abigail and the two quickly became friends. Spending time with Abigail helped tone down some of Rosemary's enthusiasm and made her a more likable person. Rosemary even came to like Elizabeth, even if only on an acquaintance level. Truthfully, she cares about everyone in Hope Valley, especially Lee, with whom she shares an mutual attraction. When Rosie is not spending time with Lee, talking to Abigail, or dreaming about the glamorous life of an actress, she can often be found somewhere writing her weekly advice column for Hope Valley's newspaper! In season 3, Rosemary's friendship with Elizabeth deepened. Instead of viewing her as an adversary, she finds a friend in Elizabeth. Throughout season 3, Rosemary's relationship with Lee becomes more romantic. In "Heart Of A Hero," seeing that Lee needs to spend more time at the sawmill to help the new settlers find jobs, Rosemary tells Lee that the theatre doesn't have to be built. He insists, but she says how important his job is. He smiles and tells her he will one day build her theatre, telling her that she is "the best part of his life." The couple shares in their first kiss. In "A Gentle Heart," Lee is injured. Thinking he is asleep, Rosemary pours out her heart to him, telling how much she loves him. In "Heartbreak," Rosemary is offered a job in Hollywood filming. This has always been Rosemary's dream, to be an actress. Lee unselfishly tells her to do whatever she feels best, but it is obvious that the thought of her leaving Hope Valley hurts him. Rosemary considers her options and realizes that her place is in Hope Valley, with Lee. Lee then tells her that he has another "role" that he thinks would be perfect for her and proposes marriage. She happily accepts. In "Hearts In Question," Rosemary enthusiastically plans for their wedding. The couple weds in the season 3 finale "Prayers From The Heart," with Elizabeth and Abigail as her maids of honor.
Leland "Lee" Coulter is a kind, laidback, patient man who opens a sawmill in Hope Valley. When timber becomes Coal Valley's major source of natural resources, the town is renamed Hope Valley. He shares a mutual attraction to Rosemary and proves to be one of the few people who can outwit her. When she declines his romantic intentions, Lee recruits his friend, Molly Sullivan, to make Rosemary jealous; the ploy succeeds and Rosemary accepts his suit, appreciating Lee's good qualities. Despite her dramatic and occasionally prickly personality, Lee's compassion and patience never fails with her. With Rosemary's help, Lee beat Mr. Gowen at his own game in "Heart and Home." When not at work, Lee enjoys being with friends, including Jack Thornton, who shares Lee's simple and laidback outlook, allowing the men to discuss their lives and exchange romantic advice. In season 3, Lee's mill is unfortunately sabotaged by a man inside. Through Bill and Jack's investigation, they find the culprit. In season 3's "Heart Of A Hero," Rosemary unselfishly gives up the theatre that Lee promised to build her. Lee promises that one day, he will build her the theatre at a time when he isn't so involved with the sawmill and finding people jobs. In "A Gentle Heart," Lee is injured. Thinking Lee is asleep, Rosemary pours out her heart to Lee, telling him how afraid she was when she heard he had been injured. He however hears each and every word. She told him how much she loves him and to never leave her. In the episode "Heartbreak," Lee thinks Rosemary may leave Hope Valley when she is offered a movie job in Hollywood. When she gives up the movie, seeing her future in Hope Valley with him, he asks her to marry him. The couple weds in the season 3 finale, "Prayers From The Heart." Jack serves the role of Lee's best man.
Julie Thatcher is Elizabeth's hopeless romantic younger sister. She often gets herself into sticky situations by falling head over heels for men who aren't quite what they seem. In season 2 she gets involved with Jack's brother Tom, which causes trouble with her family and for Jack and Elizabeth's relationship.
Cat Montgomery is a kind, encouraging woman in Coal Valley. She is a widow and mother of three: Gabe, Miles, and Emily. Cat was one of the first mothers to show kindness to Elizabeth when she first came. She desperately wants her children to remember the good memories of their father as seen by her self-sacrificing acts in "Secrets and Lies." Possessing a great sense of teamwork and encouragement, Cat supports the women of Coal Valley while working in the mines in "Cease and Desist." She is good friends with Elizabeth and Abigail. In "These Games," she also helps Jack catch a thief.
Florence Blakeley is a feisty gossip in Hope Valley. She often has a pessimistic perspective and always seems to find the negative, even in a very positive situation. In "Heart and Home," Abigail told Florence what she really thought about her, which causes Florence to rein in her negativity somewhat, though she remains fairly outspoken. While not always likable, Florence adds spice to life in Hope Valley.
Molly Sullivan is a friend of Lee Coulter and Elizabeth Thatcher. Molly's husband was killed in the mine disaster. She has a daughter Rosaleen. In season 1's "A Telling Silence," Rosaleen has trouble in school because she misses her father so much. When she runs away, Elizabeth finds her in the mine, feeling guilty that she didn't bring her father his lunch the day of the disaster because she wanted to play with a friend instead. She fears her mother will blame her, but Elizabeth convinces her that Molly will "say that she loves her more than life itself." Molly is reunited with her daughter, to the joy of the town's people. In season 2's "With All My Heart," Lee feels it's time to "play hard to get" with Rosemary, so he enlists help from Molly. She pretends to be interested in him romantically. This ploy works and Rosemary admits that she does in fact like him. Molly is a kind woman and was among the first to welcome Elizabeth to town.
Clara Stanton is the wife of Abigail's late son Peter, and is a sweet, quiet, and sensitive young woman. Abigail never knew she had a daughter-in-law until season 2's "Trials of the Heart;" with Peter having married Clara only three days before he was killed. In "Heart's Desire," Abigail invites Clara to come live with her in Hope Valley, an offer that Clara accepts.
Charles Kensington III is an old friend of Elizabeth with whom she reconnects while in Hamilton. He is interested in her, though her feelings for Jack get in the way of their relationship.
Production[edit]
The series, originally planned to be filmed in Colorado, is filmed south of Vancouver, British Columbia, on a farm surrounded by vineyards. The fictional frontier town of Coal Valley was erected in late 2013. Some of the set trimmings and a stage coach came from the Hell on Wheels set.[10] The Thatcher home is the University Women's Club of Vancouver.[11]
The series was renewed for a second season,[12] which aired from April 25 to June 13, 2015. Hallmark Channel announced in July 2015 that the series had been renewed for a third season, which aired from February 21 to April 10, 2016,[13] with a sneak peek airing during the 2015 Christmas season.[14]
In mid-2016, it was announced that Season 4 would premiere on the Hallmark Channel Christmas Day with a two-hour special. On April 11, 2016, Lissing and Krakow announced via the series' Facebook page that Hallmark Channel had renewed the series for a fourth season, which aired from February 19 to April 23, 2017.[15][16]
Filming for season five began in Vancouver on August 22, 2017, and ended on December 21, 2017.[17][18]
Broadcast[edit]
The first season of the series was subsequently picked up by CBC Television for rebroadcast as a summer series in 2015.[19] The network has since aired all five seasons.[20][21] The series became available internationally on Netflix in August 2017.
References[edit]
^ Jump up to: a b Reiher, Andrea (January 11, 2014). "'When Calls the Heart' premiere: Will you return to the frontier?". Zap2It. From Inside the Box (blog). Retrieved January 13, 2014.
Jump up ^ "'When Calls the Heart' features Aussie Mountie". Canadian Press, April 10, 2014.
Jump up ^ "Hallmark Channel - The Movie Cast". Hallmarkchannel.com. Retrieved 2014-02-28.
Jump up ^ ""When Calls the Heart," Hallmark Channel's Newest Original Primetime Series Kicks Off with a 2-Hour Special Extended Pilot on October 5" (Press release). Hallmark Channel. 24 July 2013. Retrieved 2016-01-11 – via The Futon Critic.
Jump up ^ The Deadline Team (June 12, 2013). "Hallmark Channel's 'When Calls The Heart' Adds Cast; 'Cedar Cove' July Premiere Set". Deadline.com. Retrieved 2014-01-13.
Jump up ^ "Special Announcement - When Calls the Heart". April 24, 2017. Retrieved April 24, 2017.
Jump up ^ Petski, Denise (July 31, 2017). "'When Calls The Heart' Gets Season 5 Premiere Date On Hallmark Channel". Deadline.com. Retrieved August 2, 2017.
Jump up ^ Petski, Denise (March 21, 2018). "Hallmark Channel Upfront Presentation Canceled Due To Storm, Net Makes Announcements, Including 'When Calls the Heart' Renewal, At Central Park Event". Deadline.com. Retrieved March 21, 2018.
Jump up ^ "Hallmark Channel - About the Series". Hallmarkchannel.com. Retrieved 2014-02-28.
Jump up ^ Brioux, Bill (December 6, 2013). "'When Calls The Heart' TV Series Set In Fictional Town Built In B.C." The Huffington Post. Archived from the original on December 7, 2013. Retrieved February 11, 2014.
Jump up ^ Owen, Rob (May 1, 2015). "TV Q&A: 'Grey's Anatomy,' 'Younger,' 'Bones' and a former Pittsburgh news anchor". Pittsburgh Post-Gazette. Retrieved May 1, 2015.
Jump up ^ Kondolojy, Amanda (May 5, 2014). "When Calls the Heart' Renewed for Second Season by Hallmark Channel". TV by the Numbers. Retrieved May 5, 2014.
Jump up ^ Petski, Denise (July 28, 2015). "'When Calls The Heart' Renewed For Season 3 On Hallmark Channel". Deadline Hollywood. Retrieved December 25, 2015.
Jump up ^ "When Calls the Heart videos". Hallmark Channel.
Jump up ^ McLennan, Cindy (April 11, 2016). "When Calls the Heart: Season Four Renewal for Hallmark Channel Series". TV Series Finale. Retrieved April 12, 2016.
Jump up ^ Petski, Denise (April 15, 2016). "'When Calls The Heart' Renewed For Season 4 By Hallmark Channel". Deadline Hollywood. Retrieved April 15, 2016.
Jump up ^ Takeuchi, Craig (August 21, 2017). "Filming in Vancouver: Johnny Depp, When Calls the Heart, and Eggplant Emoji". Inside Vancouver. Retrieved September 27, 2017.
Jump up ^ Krakow, Erin [@erinkrakow] (December 21, 2017). "That's a Season 5 WRAP for Elizabeth! It flew! Missing my Hope Valley friends already!" (Tweet). Retrieved December 25, 2017 – via Twitter.
Jump up ^ "CBC-TV stacks fall and winter lineups with British, Aussie fare". 680 News, May 28, 2015.
Jump up ^ "CBC Television reveals its 2016 summer schedule with five new primetime series, returning hits and the Rio 2016 Olympic Games". CBC Television. May 18, 2016. Retrieved August 3, 2017.
Jump up ^ "CBC Announces 2017-18 Programming Slate". CBC Television. May 24, 2017. Retrieved August 3, 2017.
External links[edit]
Wikiquote has quotations related to: When Calls the Heart
Official website
When Calls the Heart on IMDb
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2017 ACC Championship Game
From Wikipedia, the free encyclopedia
Jump to: navigation, search
2017 Dr Pepper ACC Championship Game
Conference Championship
Miami Hurricanes Clemson Tigers
(10–1) (11–1)
3 38
Head coach:
Mark Richt Head coach:
Dabo Swinney
AP Coaches CFP
7 7 7
AP Coaches CFP
1 1 1
1
2
3
4
Total
Miami 0 0 0 3 3
Clemson 14 7 17 0 38
Date
December 2, 2017
Season
2017
Stadium
Bank of America Stadium[1]
Location
Charlotte, NC
MVP
Kelly Bryant (Clemson)
Favorite
Clemson by 12 [2]
Referee
Jeff Flanagan
Attendance
74,372
United States TV coverage
Network
ABC/ESPN Radio
Announcers
Chris Fowler, Kirk Herbstreit, Maria Taylor, and Tom Rinaldi (ABC)
Bill Rosinski and David Norrie (ESPN Radio)
ACC Championship Game
< 2016 2018 >
2017 ACC football standings
v
t
e
Conf
Overall
Team
W
L
W
L
Atlantic Division
No. 4 Clemson xy$^ 7 – 1 12 – 2
No. 23 NC State 6 – 2 9 – 4
Boston College 4 – 4 7 – 6
Louisville 4 – 4 8 – 5
Wake Forest 4 – 4 8 – 5
Florida State 3 – 5 7 – 6
Syracuse 2 – 6 4 – 8
Coastal Division
No. 13 Miami xy 7 – 1 10 – 3
No. 24 Virginia Tech 5 – 3 9 – 4
Georgia Tech 4 – 4 5 – 6
Duke 3 – 5 7 – 6
Pittsburgh 3 – 5 5 – 7
Virginia 3 – 5 6 – 7
North Carolina 1 – 7 3 – 9
Championship: Clemson 38, Miami 3
^ – College Football Playoff participant
$ – Conference champion
x – Division champion/co-champions
y – Championship game participant
As of April 26, 2018; Rankings from AP Poll
The 2017 ACC Championship Game was played on December 2, 2017. It was the 13th annual ACC Football Conference Championship Game to determine the 2017 champion of the Atlantic Coast Conference. The game was held at Bank of America Stadium in Charlotte, North Carolina. Clemson emerged victorious and became the 2017 ACC champions, beating Miami 38-3.
Contents
[hide]
1 History
1.1 Site selection
2 Teams
2.1 #7 Miami Hurricanes
2.2 #1 Clemson Tigers
3 Scoring summary
3.1 Statistics
4 References
History[edit]
The 2017 Championship Game was the 13th in the Atlantic Coast Conference's 65-year history. Last season, the ACC Championship Game featured the Clemson Tigers, champions of the Atlantic Division, and the Virginia Tech Hokies, champions of the Coastal Division. Clemson won the game 42–35, and went on to win the 2016 College Football Playoff National Championship.
Site selection[edit]
The championship game had been hosted in Charlotte, North Carolina from 2010 to 2015, and had been slated to host through at least 2019.[3] However, in response to North Carolina's Public Facilities Privacy & Security Act (HB2), the ACC voted in September 2016 to move the 2016 championship out of North Carolina.[4] Camping World Stadium in Orlando, Florida was chosen as a replacement site for the 2016 game. ACC Commissioner John Swofford delayed the decision on where to hold the 2017 football Championship Game due to the ongoing controversy.[5][6] On April 19, 2017, the ACC announced that the football championship game and other neutral site conference events would return to Charlotte in 2017.[1]
Teams[edit]
#7 Miami Hurricanes[edit]
Main article: 2017 Miami Hurricanes football team
Miami secured its spot in the game by winning the Coastal Division. This is the first ACC divisional title and first appearance in the ACC Championship Game for the Hurricanes.[7]
#1 Clemson Tigers[edit]
Main article: 2017 Clemson Tigers football team
Clemson qualified for the game by winning the Atlantic Division with a 7–1 record. Their only loss was to Syracuse, while the Tigers defeated: Louisville, Boston College, Virginia Tech, Wake Forest, Georgia Tech, NC State, and Florida State. This is the Tiger's third straight appearance in the ACC Championship game.
Scoring summary[edit]
[hide]Scoring summary
Quarter
Time
Drive
Team
Scoring information
Score
Plays
Yards
TOP
Miami
Clemson
1 10:36 10 68 4:24 Clemson Travis Etienne 4-yard touchdown run, Alex Spence kick good 0 7
1 3:02 7 71 3:07 Clemson Kelly Bryant 11-yard touchdown run, Alex Spence kick good 0 14
2 12:49 9 41 3:46 Clemson Adam Choice 1-yard touchdown run, Alex Spence kick good 0 21
3 10:14 6 16 2:36 Clemson 46-yard field goal by Alex Spence 0 24
3 3:13 6 43 3:13 Clemson Tavien Feaster 11-yard touchdown run, Alex Spence kick good 0 31
3 1:01 2 13 0:55 Clemson Deon Cain 27-yard touchdown reception from Kelly Bryant, Alex Spence kick good 0 38
4 3:29 9 54 4:05 Miami 22-yard field goal by Michael Badgley 3 38
"TOP" = time of possession. For other American football terms, see Glossary of American football.
3
38
Source: [8]
Statistics[edit]
Statistics[8]
MIA
CU
First Downs 10 18
Total Yards 214 331
Rushing Yards 104 77
Passing yards 110 254
Passing: Comp–Att–Int 14-29–2 25-34-0
Time of possession 25:54 34:06
References[edit]
^ Jump up to: a b "ACC football championship back in Charlotte". WCNC.com. WCNC-TV. April 19, 2017. Retrieved April 20, 2017.
Jump up ^ "Miami-FL Hurricanes vs Clemson Tigers". Odds Shark. Retrieved November 28, 2017.
Jump up ^ "ACC, Charlotte look ahead to even better things". theacc.com. February 28, 2014. Retrieved February 28, 2014.
Jump up ^ "'Historically bad:' ACC pulls championships from NC". WRAL.com. September 14, 2016.
Jump up ^ McGuire, Kevin (January 8, 2017). "No decision on where 2017 ACC Championship Game will be played yet". NBCSports.com. NBC Universal. Retrieved April 15, 2017.
Jump up ^ Brenner, Aaron (January 8, 2017). "Swofford discusses ACC title events in NC, Wakeyleaks consequences". postandcourier.com. Post and Courier. Retrieved April 15, 2017.
Jump up ^ Cabrera Chirinos, Christy (November 12, 2017). "With Coastal Division clinched, Hurricanes have eyes set on new goal: the College Football Playoff". Sun Sentinel. Retrieved November 15, 2017.
^ Jump up to: a b "Miami vs Clemson (Dec 02,2017)". clemsontigers.com. Clemson University Athletic Department. Retrieved December 4, 2017.
[show]
v
t
e
ACC Championship Game
Years
2005
2006
2007
2008
2009
2010
2011
2012
2013
2014
2015
2016
2017
Venues
Jacksonville Municipal Stadium (2005–2007)
Raymond James Stadium (2008–2009)
Bank of America Stadium (2010–2015, 2017–future)
Camping World Stadium (2016)
Retrieved from "https://en.wikipedia.org/w/index.php?title=2017_ACC_Championship_Game&oldid=830146878"
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Clemson Tigers football
Miami Hurricanes football games
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text:
Lymphocyte
From Wikipedia, the free encyclopedia
Jump to: navigation, search
Lymphocyte
A scanning electron microscope (SEM) image of a single human lymphocyte.
Details
System
Immune system
Function
White blood cell
Identifiers
Latin
lymphocytes
MeSH
D008214
TH
H2.00.04.1.02002
Anatomical terms of microanatomy
[edit on Wikidata]
A lymphocyte is one of the subtypes of white blood cell in a vertebrate's immune system. Lymphocytes include natural killer cells (which function in cell-mediated, cytotoxic innate immunity), T cells (for cell-mediated, cytotoxic adaptive immunity), and B cells (for humoral, antibody-driven adaptive immunity). They are the main type of cell found in lymph, which prompted the name "lymphocyte".
Contents
[hide]
1 Types
1.1 T cells and B cells
1.2 Natural killer cells
2 Development
3 Characteristics
4 Lymphocytes and disease
4.1 High
4.2 Low
4.3 Tumor-infiltrating lymphocytes
5 Blood content
6 See also
7 Notes
8 References
9 External links
Types[edit]
A stained lymphocyte surrounded by red blood cells viewed using a light microscope.
The three major types of lymphocyte are T cells, B cells and natural killer (NK) cells. Lymphocytes can be identified by their large nucleus.
T cells and B cells[edit]
Main articles: T cell and B cell
T cells (thymus cells) and B cells (bone marrow- or bursa-derived cells[a]) are the major cellular components of the adaptive immune response. T cells are involved in cell-mediated immunity, whereas B cells are primarily responsible for humoral immunity (relating to antibodies). The function of T cells and B cells is to recognize specific “non-self” antigens, during a process known as antigen presentation. Once they have identified an invader, the cells generate specific responses that are tailored to maximally eliminate specific pathogens or pathogen-infected cells. B cells respond to pathogens by producing large quantities of antibodies which then neutralize foreign objects like bacteria and viruses. In response to pathogens some T cells, called T helper cells, produce cytokines that direct the immune response, while other T cells, called cytotoxic T cells, produce toxic granules that contain powerful enzymes which induce the death of pathogen-infected cells. Following activation, B cells and T cells leave a lasting legacy of the antigens they have encountered, in the form of memory cells. Throughout the lifetime of an animal, these memory cells will remember each specific pathogen encountered, and are able to mount a strong and rapid response if the same pathogen is detected again; this is known as acquired immunity.
Natural killer cells[edit]
Main article: Natural killer cell
NK cells are a part of the innate immune system and play a major role in defending the host from both tumors and virally infected cells. NK cells distinguish infected cells and tumors from normal and uninfected cells by recognizing changes of a surface molecule called MHC (major histocompatibility complex) class I. NK cells are activated in response to a family of cytokines called interferons. Activated NK cells release cytotoxic (cell-killing) granules which then destroy the altered cells.[2] They are named "natural killer cells" because they do not require prior activation in order to kill cells which are missing MHC class I.
Development[edit]
Development of blood cells
Mammalian stem cells differentiate into several kinds of blood cell within the bone marrow.[3] This process is called haematopoiesis. All lymphocytes originate, during this process, from a common lymphoid progenitor before differentiating into their distinct lymphocyte types. The differentiation of lymphocytes follows various pathways in a hierarchical fashion as well as in a more plastic fashion. The formation of lymphocytes is known as lymphopoiesis. B cells mature into B lymphocytes in the bursa equivalent, which in humans is the GALT, which is thought to be located in the Peyer's patches of the intestine, [4] while T cells migrate to and mature in a distinct organ, called the thymus. Following maturation, the lymphocytes enter the circulation and peripheral lymphoid organs (e.g. the spleen and lymph nodes) where they survey for invading pathogens and/or tumor cells.
The lymphocytes involved in adaptive immunity (i.e. B and T cells) differentiate further after exposure to an antigen; they form effector and memory lymphocytes. Effector lymphocytes function to eliminate the antigen, either by releasing antibodies (in the case of B cells), cytotoxic granules (cytotoxic T cells) or by signaling to other cells of the immune system (helper T cells). Memory T cells remain in the peripheral tissues and circulation for an extended time ready to respond to the same antigen upon future exposure; they live weeks to several years, which is very long compared to other leukocytes.[citation needed]
Characteristics[edit]
A scanning electron microscope image of normal circulating human blood showing red blood cells, several types of white blood cells including lymphocytes, a monocyte, a neutrophil and many small disc-shaped platelets.
Microscopically, in a Wright's stained peripheral blood smear, a normal lymphocyte has a large, dark-staining nucleus with little to no eosinophilic cytoplasm. In normal situations, the coarse, dense nucleus of a lymphocyte is approximately the size of a red blood cell (about 7 μm in diameter).[3] Some lymphocytes show a clear perinuclear zone (or halo) around the nucleus or could exhibit a small clear zone to one side of the nucleus. Polyribosomes are a prominent feature in the lymphocytes and can be viewed with an electron microscope. The ribosomes are involved in protein synthesis, allowing the generation of large quantities of cytokines and immunoglobulins by these cells.
It is impossible to distinguish between T cells and B cells in a peripheral blood smear.[3] Normally, flow cytometry testing is used for specific lymphocyte population counts. This can be used to determine the percentage of lymphocytes that contain a particular combination of specific cell surface proteins, such as immunoglobulins or cluster of differentiation (CD) markers or that produce particular proteins (for example, cytokines using intracellular cytokine staining (ICCS)). In order to study the function of a lymphocyte by virtue of the proteins it generates, other scientific techniques like the ELISPOT or secretion assay techniques can be used.[2]
Typical recognition markers for lymphocytes[5]
Class
Function
Proportion
Phenotypic marker(s)
Natural killer cells
Lysis of virally infected cells and tumour cells 7% (2–13%) CD16 CD56 but not CD3
T helper cells
Release cytokines and growth factors that regulate other immune cells 46% (28–59%) TCRαβ, CD3 and CD4
Cytotoxic T cells
Lysis of virally infected cells, tumour cells and allografts 19% (13–32%) TCRαβ, CD3 and CD8
Gamma delta T cells
Immunoregulation and cytotoxicity 5% (2–8%) TCRγδ and CD3
B cells
Secretion of antibodies 23% (18–47%) MHC class II, CD19 and CD20
In the circulatory system, they move from lymph node to lymph node. This contrasts with macrophages, which are rather stationary in the nodes.
Lymphocytes and disease[edit]
This section needs expansion. You can help by adding to it. (December 2007)
Several lymphocytes seen collected around a tuberculous granuloma.
A lymphocyte count is usually part of a peripheral complete blood cell count and is expressed as the percentage of lymphocytes to the total number of white blood cells counted.
A general increase in the number of lymphocytes is known as lymphocytosis, whereas a decrease is known as lymphocytopenia.
High[edit]
An increase in lymphocyte concentration is usually a sign of a viral infection (in some rare case, leukemias are found through an abnormally raised lymphocyte count in an otherwise normal person). A high lymphocyte count with a low neutrophil count might be caused by lymphoma. Pertussis toxin (PTx) of Bordetella pertussis, formerly known as lymphocytosis-promoting factor, causes a decrease in the entry of lymphocytes into lymph nodes, which can lead to a condition known as lymphocytosis, with a complete lymphocyte count of over 4000 per μl in adults or over 8000 per μl in children. This is unique in that many bacterial infections illustrate neutrophil-predominance instead.
Low[edit]
A low normal to low absolute lymphocyte concentration is associated with increased rates of infection after surgery or trauma.
One basis for low T cell lymphocytes occurs when the human immunodeficiency virus (HIV) infects and destroys T cells (specifically, the CD4+ subgroup of T lymphocytes). Without the key defense that these T cells provide, the body becomes susceptible to opportunistic infections that otherwise would not affect healthy people. The extent of HIV progression is typically determined by measuring the percentage of CD4+ T cells in the patient's blood – HIV ultimately progresses to acquired immune deficiency syndrome (AIDS). The effects of other viruses or lymphocyte disorders can also often be estimated by counting the numbers of lymphocytes present in the blood.
Tumor-infiltrating lymphocytes[edit]
Main article: Tumor-infiltrating lymphocyte
In some cancers, such as melanoma and colorectal cancer, lymphocytes can migrate into and attack the tumor. This can sometimes lead to regression of the primary tumor.
Blood content[edit]
Reference ranges for blood tests of white blood cells, comparing lymphocyte amount (shown in light blue) with other cells.
See also[edit]
Addressin
Anergy
Complete blood count
Cytotoxicity
Human leukocyte antigen
Innate lymphoid cell
Lymphoproliferative disorders
Reactive lymphocyte
Secretion assay
Trogocytosis
Notes[edit]
Jump up ^ The process of B-cell maturation was elucidated in birds and the B most likely means "bursa-derived" referring to the bursa of Fabricius.[1] However, in humans (who do not have that organ), the bone marrow makes B cells, and the B can serve as a reminder of bone marrow.
References[edit]
Jump up ^ "B Cell". Merriam-Webster Dictionary. Encyclopaedia Britannica. Retrieved 28 October 2011.
^ Jump up to: a b Janeway, Charles; Travers, Paul; Walport, Mark; Shlomchik, Mark (2001). Immunobiology (5th ed.). New York and London: Garland Science. ISBN 0-8153-4101-6. .
^ Jump up to: a b c Abbas, A. K.; Lichtman, A. H. (2003). Cellular and Molecular Immunology (5th ed.). Saunders, Philadelphia. ISBN 0-7216-0008-5.
Jump up ^ Kumar, Abbas Fausto. Pathologic Basis of Disease (7th ed.).
Jump up ^ Berrington, J. E.; Barge, D.; Fenton, A. C.; Cant, A. J.; Spickett, G. P. (May 2005). "Lymphocyte subsets in term and significantly preterm UK infants in the first year of life analysed by single platform flow cytometry". Clinical Experimental Immunology. 140 (2): 289–92. doi:10.1111/j.1365-2249.2005.02767.x. PMC 1809375  . PMID 15807853.
External links[edit]
Wikimedia Commons has media related to Lymphocytes.
Histology image: 01701ooa – Histology Learning System at Boston University
"Cytotoxic T Lymphocyte". Cell Centered Database.
"Overcoming the Rejection Factor: MUSC's First Organ Transplant". Waring Historical Library.
[hide]
v
t
e
Lymphocytes
B cells
Plasma
Memory
Follicular
Marginal zone
Naïve
Pre-B
Thymocyte
T cells
αβ (Cytotoxic CD8+
Helper CD4+ / TFH / Th3 / Th17 / Regulatory)
γδ
Naïve
Natural killer T cell
NK cells
Cytokine-induced killer cell
Lymphokine-activated killer cell
Null cell
Lymphopoiesis
Hematopoietic stem cell
Lymphoblast
Prolymphocyte
Retrieved from "https://en.wikipedia.org/w/index.php?title=Lymphocyte&oldid=835671228"
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Chief business development officer
From Wikipedia, the free encyclopedia
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A chief business development officer (CBDO) is a position within a company established beside the other executive positions like CEO or COO. The title is used to define a high-ranking position alongside the CEO. The CBDO is expected to have a broad and comprehensive knowledge of all matters related to the business of the organization with an eye towards identifying new sales prospects and driving business growth and requirements for product development that will be coordinated with R&D functions[1].
Responsibilities can include:
Elaborate business development plans, design and implement processes to support business growth, through customer and market definition.
Facilitate business growth by working together with clients as well as business partners (suppliers, subcontractors, JV partners, technology providers, etc.).
Build and maintain high-level contacts with current and prospective customer and other business and project partners.
Drive prospects through to contract award (including identifying new customers and markets, developing approaches to the market, identifying prospects, proposal preparation, etc.)
Develop marketing strategy, manage proposal teams and client account managers.
Develop Applications and other Systems.
References[edit]
Jump up ^ "Salary.com alternate job titles for Top Business Development Executive – Senior Development Officer (CBDO)".
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