| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27547 | 185 | 27362 | 99.33 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 3470.503 | 3388.510 |
| AIC | 3470.503 | 3404.510 |
| SBC | 3470.503 | 3430.273 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 81.9928 | 8 | <.0001 |
| Score (Model-Based) | 70.1923 | 8 | <.0001 |
| Score (Sandwich) | 139.5912 | 8 | <.0001 |
| Wald (Model-Based) | 47.7029 | 8 | <.0001 |
| Wald (Sandwich) | 1134.2753 | 5 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 14.5669 | 0.0007 |
| database | 2 | 1875.3257 | <.0001 |
| exposure*database | 4 | 964.7163 | <.0001 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -0.38016 | 0.49491 | 0.997 | 0.5900 | 0.4424 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | 0.55499 | 0.45963 | 1.002 | 1.4580 | 0.2273 | exposure No exposure | ||||
| database | MPCD | 1 | -13.33721 | 0.41394 | 0.001 | 1038.1312 | <.0001 | database MPCD | ||||
| database | Marketscan | 1 | -1.92663 | 0.66964 | 0.998 | 8.2777 | 0.0040 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 0.31167 | 0.46749 | 0.001 | 0.4445 | 0.5050 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | 1.60910 | 0.77057 | 0.999 | 4.3605 | 0.0368 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 12.59468 | 0.55386 | 0.002 | 517.1045 | <.0001 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 1.16348 | 0.71161 | 0.999 | 2.6733 | 0.1020 | exposure No exposure * database Marketscan |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 0.934 | 0.934 | 0.934 |
| exposure No exposure vs TNF At database=MPCD | 513843.0 | 278352.5 | 948561.9 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 3.418 | 1.070 | 10.912 |
| exposure No exposure vs TNF At database=Marketscan | 5.576 | 1.914 | 16.245 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.684 | 0.259 | 1.804 |
| exposure No exposure vs TNF At database=Medicare | 1.742 | 0.708 | 4.288 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27547 | 185 | 27362 | 99.33 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 7944.865 | 7690.843 |
| AIC | 7944.865 | 7706.843 |
| SBC | 7944.865 | 7732.606 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 254.0219 | 8 | <.0001 |
| Score (Model-Based) | 213.6450 | 8 | <.0001 |
| Score (Sandwich) | 90.7367 | 8 | <.0001 |
| Wald (Model-Based) | 123.8684 | 8 | <.0001 |
| Wald (Sandwich) | 14538.9950 | 8 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 16.1933 | 0.0003 |
| database | 2 | 820.9779 | <.0001 |
| exposure*database | 4 | 1075.0941 | <.0001 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -0.97262 | 0.92858 | 4.145 | 1.0971 | 0.2949 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | 0.14410 | 0.73107 | 5.951 | 0.0389 | 0.8437 | exposure No exposure | ||||
| database | MPCD | 1 | -14.87459 | 0.84044 | 0.003 | 313.2395 | <.0001 | database MPCD | ||||
| database | Marketscan | 1 | -2.24617 | 0.99344 | 3.872 | 5.1122 | 0.0238 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 0.90274 | 0.84712 | 0.001 | 1.1356 | 0.2866 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | 2.01632 | 1.04570 | 2.504 | 3.7180 | 0.0538 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 13.98238 | 0.85812 | 0.004 | 265.5029 | <.0001 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 1.44269 | 0.94822 | 2.855 | 2.3149 | 0.1281 | exposure No exposure * database Marketscan |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 0.933 | 0.661 | 1.316 |
| exposure No exposure vs TNF At database=MPCD | 1364741 | 648568.8 | 2871737 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 2.840 | 0.826 | 9.767 |
| exposure No exposure vs TNF At database=Marketscan | 4.888 | 1.561 | 15.309 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.378 | 0.061 | 2.333 |
| exposure No exposure vs TNF At database=Medicare | 1.155 | 0.276 | 4.840 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||||
|---|---|---|---|---|---|
| Class | Value | Design Variables | |||
| exposure | DMARD or NSAID | 1 | 0 | ||
| No exposure | 0 | 1 | |||
| TNF | 0 | 0 | |||
| database | MPCD | 1 | 0 | ||
| Marketscan | 0 | 1 | |||
| Medicare | 0 | 0 | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 0 | 0 | 0 |
| Low (<2.5 mg/d) | 0 | 1 | 0 | 0 | |
| Medium-High (5-10 mg/d) | 0 | 0 | 1 | 0 | |
| Medium-Low (2.5-5 mg/d) | 0 | 0 | 0 | 1 | |
| None | 0 | 0 | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27547 | 185 | 27362 | 99.33 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 7944.865 | 7547.742 |
| AIC | 7944.865 | 7571.742 |
| SBC | 7944.865 | 7610.387 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 397.1229 | 12 | <.0001 |
| Score (Model-Based) | 378.0868 | 12 | <.0001 |
| Score (Sandwich) | 107.7786 | 12 | <.0001 |
| Wald (Model-Based) | 275.0900 | 12 | <.0001 |
| Wald (Sandwich) | 19498.5652 | 12 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 17.1649 | 0.0002 |
| database | 2 | 877.4824 | <.0001 |
| exposure*database | 4 | 1009.4277 | <.0001 |
| meanPredEqDoseCat | 4 | 7.5422 | 0.1099 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -1.00372 | 0.93894 | 4.192 | 1.1427 | 0.2851 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | 0.19278 | 0.70541 | 5.720 | 0.0747 | 0.7846 | exposure No exposure | ||||
| database | MPCD | 1 | -14.89314 | 0.84107 | 0.003 | 313.5521 | <.0001 | database MPCD | ||||
| database | Marketscan | 1 | -2.31058 | 1.02847 | 4.007 | 5.0473 | 0.0247 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 0.85039 | 0.78329 | 0.001 | 1.1786 | 0.2776 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | 1.98138 | 1.02633 | 2.457 | 3.7270 | 0.0535 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 14.16052 | 0.94474 | 0.004 | 224.6627 | <.0001 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 1.52038 | 0.97768 | 2.942 | 2.4183 | 0.1199 | exposure No exposure * database Marketscan | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 1.19968 | 0.71388 | 1.260 | 2.8241 | 0.0929 | 3.319 | 0.819 | 13.449 | meanPredEqDoseCat High (10+ mg/d) | |
| meanPredEqDoseCat | Low (<2.5 mg/d) | 1 | 1.28934 | 0.72281 | 6.787 | 3.1819 | 0.0745 | 3.630 | 0.880 | 14.969 | meanPredEqDoseCat Low (<2.5 mg/d) | |
| meanPredEqDoseCat | Medium-High (5-10 mg/d) | 1 | 0.36085 | 0.44218 | 1.219 | 0.6660 | 0.4145 | 1.435 | 0.603 | 3.413 | meanPredEqDoseCat Medium-High (5-10 mg/d) | |
| meanPredEqDoseCat | Medium-Low (2.5-5 mg/d) | 1 | 0.16760 | 0.36318 | 1.337 | 0.2130 | 0.6444 | 1.182 | 0.580 | 2.410 | meanPredEqDoseCat Medium-Low (2.5-5 mg/d) |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 0.858 | 0.551 | 1.336 |
| exposure No exposure vs TNF At database=MPCD | 1712221 | 757413.9 | 3870674 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 2.658 | 0.763 | 9.266 |
| exposure No exposure vs TNF At database=Marketscan | 5.546 | 1.745 | 17.632 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.367 | 0.058 | 2.308 |
| exposure No exposure vs TNF At database=Medicare | 1.213 | 0.304 | 4.833 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 | |
| SEX | F | 1 | |
| M | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27547 | 185 | 27362 | 99.33 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 7944.865 | 7626.183 |
| AIC | 7944.865 | 7644.183 |
| SBC | 7944.865 | 7673.166 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 318.6826 | 9 | <.0001 |
| Score (Model-Based) | 279.6222 | 9 | <.0001 |
| Score (Sandwich) | 110.4290 | 9 | <.0001 |
| Wald (Model-Based) | 187.1183 | 9 | <.0001 |
| Wald (Sandwich) | 21748.8607 | 9 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 16.8507 | 0.0002 |
| database | 2 | 833.0675 | <.0001 |
| exposure*database | 4 | 1074.7223 | <.0001 |
| SEX | 1 | 2.1170 | 0.1457 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -0.82643 | 0.84375 | 3.753 | 0.9594 | 0.3273 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | 0.28538 | 0.65553 | 5.312 | 0.1895 | 0.6633 | exposure No exposure | ||||
| database | MPCD | 1 | -14.89754 | 0.84071 | 0.003 | 314.0040 | <.0001 | database MPCD | ||||
| database | Marketscan | 1 | -2.25216 | 0.99816 | 3.890 | 5.0909 | 0.0241 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 0.81658 | 0.78527 | 0.001 | 1.0814 | 0.2984 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | 1.92739 | 1.00493 | 2.405 | 3.6785 | 0.0551 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 13.86878 | 0.78840 | 0.003 | 309.4413 | <.0001 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 1.29547 | 0.88836 | 2.672 | 2.1265 | 0.1448 | exposure No exposure * database Marketscan | |||
| SEX | F | 1 | -0.83821 | 0.57610 | 5.454 | 2.1170 | 0.1457 | 0.432 | 0.140 | 1.338 | Administrative Sex F |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 0.990 | 0.726 | 1.350 |
| exposure No exposure vs TNF At database=MPCD | 1403056 | 670950.4 | 2933997 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 3.007 | 0.884 | 10.228 |
| exposure No exposure vs TNF At database=Marketscan | 4.859 | 1.552 | 15.213 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.438 | 0.084 | 2.287 |
| exposure No exposure vs TNF At database=Medicare | 1.330 | 0.368 | 4.808 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27547 | 185 | 27362 | 99.33 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 7944.865 | 7689.979 |
| AIC | 7944.865 | 7707.979 |
| SBC | 7944.865 | 7736.962 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 254.8861 | 9 | <.0001 |
| Score (Model-Based) | 214.7199 | 9 | <.0001 |
| Score (Sandwich) | 127.9926 | 9 | <.0001 |
| Wald (Model-Based) | 124.7664 | 9 | <.0001 |
| Wald (Sandwich) | 23142.0351 | 9 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 19.6521 | <.0001 |
| database | 2 | 774.2107 | <.0001 |
| exposure*database | 4 | 960.5972 | <.0001 |
| indHospInf | 1 | 0.0374 | 0.8467 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -0.99452 | 0.87458 | 3.880 | 1.2931 | 0.2555 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | 0.16118 | 0.77305 | 6.211 | 0.0435 | 0.8348 | exposure No exposure | ||||
| database | MPCD | 1 | -14.85881 | 0.89168 | 0.004 | 277.6818 | <.0001 | database MPCD | ||||
| database | Marketscan | 1 | -2.23253 | 1.02795 | 3.999 | 4.7169 | 0.0299 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 0.92435 | 0.80187 | 0.001 | 1.3288 | 0.2490 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | 2.03603 | 1.01051 | 2.416 | 4.0597 | 0.0439 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 13.96722 | 0.89755 | 0.004 | 242.1593 | <.0001 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 1.42963 | 0.97448 | 2.931 | 2.1523 | 0.1424 | exposure No exposure * database Marketscan | |||
| indHospInf | 1 | 0.22450 | 1.16120 | 4.952 | 0.0374 | 0.8467 | 1.252 | 0.129 | 12.187 |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 0.932 | 0.662 | 1.312 |
| exposure No exposure vs TNF At database=MPCD | 1367371 | 649998.8 | 2876472 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 2.834 | 0.826 | 9.719 |
| exposure No exposure vs TNF At database=Marketscan | 4.908 | 1.569 | 15.353 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.370 | 0.067 | 2.054 |
| exposure No exposure vs TNF At database=Medicare | 1.175 | 0.258 | 5.346 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||||
|---|---|---|---|---|---|
| Class | Value | Design Variables | |||
| exposure | DMARD or NSAID | 1 | 0 | ||
| No exposure | 0 | 1 | |||
| TNF | 0 | 0 | |||
| database | MPCD | 1 | 0 | ||
| Marketscan | 0 | 1 | |||
| Medicare | 0 | 0 | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 0 | 0 | 0 |
| Low (<2.5 mg/d) | 0 | 1 | 0 | 0 | |
| Medium-High (5-10 mg/d) | 0 | 0 | 1 | 0 | |
| Medium-Low (2.5-5 mg/d) | 0 | 0 | 0 | 1 | |
| None | 0 | 0 | 0 | 0 | |
| SEX | F | 1 | |||
| M | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27547 | 185 | 27362 | 99.33 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 7944.865 | 7465.845 |
| AIC | 7944.865 | 7493.845 |
| SBC | 7944.865 | 7538.930 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 479.0205 | 14 | <.0001 |
| Score (Model-Based) | 462.0612 | 14 | <.0001 |
| Score (Sandwich) | 128.5145 | 14 | <.0001 |
| Wald (Model-Based) | 356.2823 | 14 | <.0001 |
| Wald (Sandwich) | 21049.2983 | 14 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 23.2552 | <.0001 |
| database | 2 | 898.0295 | <.0001 |
| exposure*database | 4 | 747.2172 | <.0001 |
| meanPredEqDoseCat | 4 | 6.2562 | 0.1808 |
| SEX | 1 | 2.2033 | 0.1377 |
| indHospInf | 1 | 0.0142 | 0.9050 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -0.89708 | 0.82910 | 3.679 | 1.1707 | 0.2793 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | 0.32209 | 0.70211 | 5.618 | 0.2105 | 0.6464 | exposure No exposure | ||||
| database | MPCD | 1 | -14.94830 | 0.88444 | 0.004 | 285.6579 | <.0001 | database MPCD | ||||
| database | Marketscan | 1 | -2.33547 | 1.08945 | 4.236 | 4.5955 | 0.0321 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 0.83051 | 0.65526 | 0.001 | 1.6064 | 0.2050 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | 1.94271 | 0.97875 | 2.341 | 3.9398 | 0.0472 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 14.10462 | 0.94554 | 0.004 | 222.5151 | <.0001 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 1.38642 | 0.96378 | 2.896 | 2.0693 | 0.1503 | exposure No exposure * database Marketscan | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 1.47690 | 0.68530 | 1.208 | 4.6445 | 0.0312 | 4.379 | 1.143 | 16.778 | meanPredEqDoseCat High (10+ mg/d) | |
| meanPredEqDoseCat | Low (<2.5 mg/d) | 1 | 1.36855 | 0.81861 | 7.636 | 2.7949 | 0.0946 | 3.930 | 0.790 | 19.550 | meanPredEqDoseCat Low (<2.5 mg/d) | |
| meanPredEqDoseCat | Medium-High (5-10 mg/d) | 1 | 0.41114 | 0.44841 | 1.235 | 0.8407 | 0.3592 | 1.509 | 0.626 | 3.633 | meanPredEqDoseCat Medium-High (5-10 mg/d) | |
| meanPredEqDoseCat | Medium-Low (2.5-5 mg/d) | 1 | 0.27905 | 0.41448 | 1.519 | 0.4533 | 0.5008 | 1.322 | 0.587 | 2.979 | meanPredEqDoseCat Medium-Low (2.5-5 mg/d) | |
| SEX | F | 1 | -0.94236 | 0.63486 | 6.012 | 2.2033 | 0.1377 | 0.390 | 0.112 | 1.352 | Administrative Sex F | |
| indHospInf | 1 | 0.15033 | 1.25962 | 5.347 | 0.0142 | 0.9050 | 1.162 | 0.098 | 13.724 |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 0.936 | 0.562 | 1.557 |
| exposure No exposure vs TNF At database=MPCD | 1842654 | 819333.5 | 4144067 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 2.845 | 0.832 | 9.731 |
| exposure No exposure vs TNF At database=Marketscan | 5.521 | 1.750 | 17.412 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.408 | 0.080 | 2.071 |
| exposure No exposure vs TNF At database=Medicare | 1.380 | 0.349 | 5.464 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptwStabilized |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||||
|---|---|---|---|---|---|
| Class | Value | Design Variables | |||
| exposure | DMARD or NSAID | 1 | 0 | ||
| No exposure | 0 | 1 | |||
| TNF | 0 | 0 | |||
| database | MPCD | 1 | 0 | ||
| Marketscan | 0 | 1 | |||
| Medicare | 0 | 0 | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 0 | 0 | 0 |
| Low (<2.5 mg/d) | 0 | 1 | 0 | 0 | |
| Medium-High (5-10 mg/d) | 0 | 0 | 1 | 0 | |
| Medium-Low (2.5-5 mg/d) | 0 | 0 | 0 | 1 | |
| None | 0 | 0 | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27547 | 185 | 27362 | 99.33 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 813.245 | 735.188 |
| AIC | 813.245 | 759.188 |
| SBC | 813.245 | 797.832 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 78.0577 | 12 | <.0001 |
| Score (Model-Based) | 86.2092 | 12 | <.0001 |
| Score (Sandwich) | 135.2639 | 12 | <.0001 |
| Wald (Model-Based) | 53.1973 | 12 | <.0001 |
| Wald (Sandwich) | 16920.4057 | 12 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 13.3549 | 0.0013 |
| database | 2 | 1053.0328 | <.0001 |
| exposure*database | 4 | 1219.4231 | <.0001 |
| meanPredEqDoseCat | 4 | 4.9351 | 0.2940 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -0.98666 | 0.96082 | 0.956 | 1.0545 | 0.3045 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | 0.20009 | 0.68599 | 1.225 | 0.0851 | 0.7705 | exposure No exposure | ||||
| database | MPCD | 1 | -16.22121 | 0.84580 | 0.001 | 367.8167 | <.0001 | database MPCD | ||||
| database | Marketscan | 1 | -2.32793 | 1.03128 | 2.379 | 5.0955 | 0.0240 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 0.86317 | 0.78142 | 0.000 | 1.2202 | 0.2693 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | 1.98992 | 1.01995 | 0.858 | 3.8064 | 0.0511 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 15.51175 | 0.93268 | 0.001 | 276.6040 | <.0001 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 1.53258 | 0.96129 | 1.226 | 2.5418 | 0.1109 | exposure No exposure * database Marketscan | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 0.26089 | 0.77169 | 0.279 | 0.1143 | 0.7353 | 1.298 | 0.286 | 5.891 | meanPredEqDoseCat High (10+ mg/d) | |
| meanPredEqDoseCat | Low (<2.5 mg/d) | 1 | 1.48784 | 0.74992 | 2.389 | 3.9362 | 0.0473 | 4.428 | 1.018 | 19.253 | meanPredEqDoseCat Low (<2.5 mg/d) | |
| meanPredEqDoseCat | Medium-High (5-10 mg/d) | 1 | 0.41346 | 0.65302 | 0.577 | 0.4009 | 0.5266 | 1.512 | 0.420 | 5.438 | meanPredEqDoseCat Medium-High (5-10 mg/d) | |
| meanPredEqDoseCat | Medium-Low (2.5-5 mg/d) | 1 | 0.41646 | 0.61731 | 0.810 | 0.4551 | 0.4999 | 1.517 | 0.452 | 5.085 | meanPredEqDoseCat Medium-Low (2.5-5 mg/d) |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 0.884 | 0.531 | 1.471 |
| exposure No exposure vs TNF At database=MPCD | 6661424 | 2875604 | 15431394 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 2.727 | 0.801 | 9.288 |
| exposure No exposure vs TNF At database=Marketscan | 5.656 | 1.773 | 18.042 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.373 | 0.057 | 2.451 |
| exposure No exposure vs TNF At database=Medicare | 1.222 | 0.318 | 4.686 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27652 | 717 | 26935 | 97.41 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 11071.180 | 10930.584 |
| AIC | 11071.180 | 10946.584 |
| SBC | 11071.180 | 10983.185 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 140.5954 | 8 | <.0001 |
| Score (Model-Based) | 192.9813 | 8 | <.0001 |
| Score (Sandwich) | 74.8477 | 8 | <.0001 |
| Wald (Model-Based) | 169.2946 | 8 | <.0001 |
| Wald (Sandwich) | 167.8685 | 8 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 134.4678 | <.0001 |
| database | 2 | 17.7689 | 0.0001 |
| exposure*database | 4 | 20.2445 | 0.0004 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | 0.38983 | 0.21481 | 1.028 | 3.2933 | 0.0696 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | -0.88938 | 0.20171 | 1.040 | 19.4412 | <.0001 | exposure No exposure | ||||
| database | MPCD | 1 | -0.60182 | 0.38604 | 1.006 | 2.4304 | 0.1190 | database MPCD | ||||
| database | Marketscan | 1 | -1.18501 | 0.28112 | 1.044 | 17.7688 | <.0001 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | -0.63331 | 0.70003 | 1.002 | 0.8185 | 0.3656 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | -0.45868 | 0.44519 | 1.018 | 1.0615 | 0.3029 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 0.57221 | 0.45038 | 0.997 | 1.6142 | 0.2039 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.93610 | 0.32659 | 1.026 | 8.2155 | 0.0042 | exposure No exposure * database Marketscan |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 0.784 | 0.213 | 2.888 |
| exposure No exposure vs TNF At database=MPCD | 0.728 | 0.330 | 1.606 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.933 | 0.435 | 2.003 |
| exposure No exposure vs TNF At database=Marketscan | 1.048 | 0.631 | 1.739 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 1.477 | 0.969 | 2.250 |
| exposure No exposure vs TNF At database=Medicare | 0.411 | 0.277 | 0.610 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27652 | 717 | 26935 | 97.41 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 26828.495 | 26422.277 |
| AIC | 26828.495 | 26438.277 |
| SBC | 26828.495 | 26474.877 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 406.2179 | 8 | <.0001 |
| Score (Model-Based) | 442.5409 | 8 | <.0001 |
| Score (Sandwich) | 70.1866 | 8 | <.0001 |
| Wald (Model-Based) | 400.2161 | 8 | <.0001 |
| Wald (Sandwich) | 138.5874 | 8 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 50.6240 | <.0001 |
| database | 2 | 9.3975 | 0.0091 |
| exposure*database | 4 | 17.8173 | 0.0013 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | 0.39053 | 0.29949 | 3.056 | 1.7004 | 0.1922 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | -0.90291 | 0.24532 | 3.903 | 13.5463 | 0.0002 | exposure No exposure | ||||
| database | MPCD | 1 | -0.40476 | 0.79008 | 6.316 | 0.2625 | 0.6084 | database MPCD | ||||
| database | Marketscan | 1 | -1.14961 | 0.38473 | 3.543 | 8.9286 | 0.0028 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | -0.89679 | 0.94563 | 1.757 | 0.8994 | 0.3429 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | -0.64893 | 0.49399 | 1.461 | 1.7257 | 0.1890 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 0.35667 | 0.75845 | 2.924 | 0.2211 | 0.6382 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.81832 | 0.38312 | 1.995 | 4.5622 | 0.0327 | exposure No exposure * database Marketscan |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 0.603 | 0.104 | 3.494 |
| exposure No exposure vs TNF At database=MPCD | 0.579 | 0.137 | 2.452 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.772 | 0.346 | 1.724 |
| exposure No exposure vs TNF At database=Marketscan | 0.919 | 0.518 | 1.629 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 1.478 | 0.822 | 2.658 |
| exposure No exposure vs TNF At database=Medicare | 0.405 | 0.251 | 0.656 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||||
|---|---|---|---|---|---|
| Class | Value | Design Variables | |||
| exposure | DMARD or NSAID | 1 | 0 | ||
| No exposure | 0 | 1 | |||
| TNF | 0 | 0 | |||
| database | MPCD | 1 | 0 | ||
| Marketscan | 0 | 1 | |||
| Medicare | 0 | 0 | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 0 | 0 | 0 |
| Low (<2.5 mg/d) | 0 | 1 | 0 | 0 | |
| Medium-High (5-10 mg/d) | 0 | 0 | 1 | 0 | |
| Medium-Low (2.5-5 mg/d) | 0 | 0 | 0 | 1 | |
| None | 0 | 0 | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27652 | 717 | 26935 | 97.41 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 26828.495 | 26359.130 |
| AIC | 26828.495 | 26383.130 |
| SBC | 26828.495 | 26438.030 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 469.3650 | 12 | <.0001 |
| Score (Model-Based) | 510.3243 | 12 | <.0001 |
| Score (Sandwich) | 74.6367 | 12 | <.0001 |
| Wald (Model-Based) | 466.6886 | 12 | <.0001 |
| Wald (Sandwich) | 163.2644 | 12 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 47.5201 | <.0001 |
| database | 2 | 9.5233 | 0.0086 |
| exposure*database | 4 | 18.9322 | 0.0008 |
| meanPredEqDoseCat | 4 | 4.0990 | 0.3928 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | 0.35490 | 0.29900 | 3.050 | 1.4088 | 0.2353 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | -0.90150 | 0.24378 | 3.873 | 13.6754 | 0.0002 | exposure No exposure | ||||
| database | MPCD | 1 | -0.41432 | 0.75031 | 5.994 | 0.3049 | 0.5808 | database MPCD | ||||
| database | Marketscan | 1 | -1.17193 | 0.38893 | 3.580 | 9.0796 | 0.0026 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | -0.87614 | 0.91168 | 1.694 | 0.9235 | 0.3365 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | -0.64012 | 0.49276 | 1.457 | 1.6875 | 0.1939 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 0.43721 | 0.70664 | 2.721 | 0.3828 | 0.5361 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.85182 | 0.38156 | 1.987 | 4.9839 | 0.0256 | exposure No exposure * database Marketscan | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | -0.68769 | 0.85110 | 1.227 | 0.6529 | 0.4191 | 0.503 | 0.095 | 2.666 | meanPredEqDoseCat High (10+ mg/d) | |
| meanPredEqDoseCat | Low (<2.5 mg/d) | 1 | 0.44715 | 0.28954 | 4.980 | 2.3849 | 0.1225 | 1.564 | 0.887 | 2.758 | meanPredEqDoseCat Low (<2.5 mg/d) | |
| meanPredEqDoseCat | Medium-High (5-10 mg/d) | 1 | -0.04011 | 0.49474 | 2.832 | 0.0066 | 0.9354 | 0.961 | 0.364 | 2.533 | meanPredEqDoseCat Medium-High (5-10 mg/d) | |
| meanPredEqDoseCat | Medium-Low (2.5-5 mg/d) | 1 | 0.37546 | 0.36410 | 3.175 | 1.0634 | 0.3024 | 1.456 | 0.713 | 2.972 | meanPredEqDoseCat Medium-Low (2.5-5 mg/d) |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 0.594 | 0.108 | 3.262 |
| exposure No exposure vs TNF At database=MPCD | 0.629 | 0.164 | 2.403 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.752 | 0.335 | 1.687 |
| exposure No exposure vs TNF At database=Marketscan | 0.952 | 0.534 | 1.695 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 1.426 | 0.794 | 2.562 |
| exposure No exposure vs TNF At database=Medicare | 0.406 | 0.252 | 0.655 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 | |
| SEX | F | 1 | |
| M | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27652 | 717 | 26935 | 97.41 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 26828.495 | 26328.988 |
| AIC | 26828.495 | 26346.988 |
| SBC | 26828.495 | 26388.163 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 499.5069 | 9 | <.0001 |
| Score (Model-Based) | 536.3028 | 9 | <.0001 |
| Score (Sandwich) | 72.6070 | 9 | <.0001 |
| Wald (Model-Based) | 490.7274 | 9 | <.0001 |
| Wald (Sandwich) | 144.6375 | 9 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 43.0366 | <.0001 |
| database | 2 | 8.9450 | 0.0114 |
| exposure*database | 4 | 16.0400 | 0.0030 |
| SEX | 1 | 4.2235 | 0.0399 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | 0.51804 | 0.29150 | 2.942 | 3.1582 | 0.0755 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | -0.75847 | 0.24501 | 3.811 | 9.5829 | 0.0020 | exposure No exposure | ||||
| database | MPCD | 1 | -0.42800 | 0.82717 | 6.607 | 0.2677 | 0.6049 | database MPCD | ||||
| database | Marketscan | 1 | -1.12888 | 0.38553 | 3.547 | 8.5739 | 0.0034 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | -0.96590 | 0.95830 | 1.780 | 1.0159 | 0.3135 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | -0.74008 | 0.49232 | 1.455 | 2.2598 | 0.1328 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 0.28372 | 0.77135 | 2.973 | 0.1353 | 0.7130 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.67673 | 0.37974 | 1.973 | 3.1758 | 0.0747 | exposure No exposure * database Marketscan | |||
| SEX | F | 1 | -0.50951 | 0.24793 | 4.661 | 4.2235 | 0.0399 | 0.601 | 0.370 | 0.977 | Administrative Sex F |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 0.639 | 0.104 | 3.945 |
| exposure No exposure vs TNF At database=MPCD | 0.622 | 0.135 | 2.859 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.801 | 0.359 | 1.784 |
| exposure No exposure vs TNF At database=Marketscan | 0.922 | 0.520 | 1.633 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 1.679 | 0.948 | 2.972 |
| exposure No exposure vs TNF At database=Medicare | 0.468 | 0.290 | 0.757 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27652 | 717 | 26935 | 97.41 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 26828.495 | 26251.993 |
| AIC | 26828.495 | 26269.993 |
| SBC | 26828.495 | 26311.169 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 576.5011 | 9 | <.0001 |
| Score (Model-Based) | 883.7223 | 9 | <.0001 |
| Score (Sandwich) | 70.9362 | 9 | <.0001 |
| Wald (Model-Based) | 693.3094 | 9 | <.0001 |
| Wald (Sandwich) | 190.0220 | 9 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 15.8410 | 0.0004 |
| database | 2 | 8.6776 | 0.0131 |
| exposure*database | 4 | 10.7509 | 0.0295 |
| indHospInf | 1 | 4.5398 | 0.0331 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | 0.20216 | 0.37119 | 3.717 | 0.2966 | 0.5860 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | -0.82218 | 0.24868 | 3.885 | 10.9308 | 0.0009 | exposure No exposure | ||||
| database | MPCD | 1 | -0.25183 | 0.78199 | 6.199 | 0.1037 | 0.7474 | database MPCD | ||||
| database | Marketscan | 1 | -1.02983 | 0.36154 | 3.311 | 8.1135 | 0.0044 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | -0.69521 | 0.95580 | 1.774 | 0.5291 | 0.4670 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | -0.48183 | 0.52289 | 1.545 | 0.8491 | 0.3568 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 0.27566 | 0.75686 | 2.914 | 0.1327 | 0.7157 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.75786 | 0.37927 | 1.973 | 3.9928 | 0.0457 | exposure No exposure * database Marketscan | |||
| indHospInf | 1 | 1.42465 | 0.66864 | 7.025 | 4.5398 | 0.0331 | 4.156 | 1.121 | 15.412 |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 0.611 | 0.106 | 3.519 |
| exposure No exposure vs TNF At database=MPCD | 0.579 | 0.137 | 2.442 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.756 | 0.337 | 1.697 |
| exposure No exposure vs TNF At database=Marketscan | 0.938 | 0.526 | 1.670 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 1.224 | 0.591 | 2.534 |
| exposure No exposure vs TNF At database=Medicare | 0.439 | 0.270 | 0.715 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||||
|---|---|---|---|---|---|
| Class | Value | Design Variables | |||
| exposure | DMARD or NSAID | 1 | 0 | ||
| No exposure | 0 | 1 | |||
| TNF | 0 | 0 | |||
| database | MPCD | 1 | 0 | ||
| Marketscan | 0 | 1 | |||
| Medicare | 0 | 0 | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 0 | 0 | 0 |
| Low (<2.5 mg/d) | 0 | 1 | 0 | 0 | |
| Medium-High (5-10 mg/d) | 0 | 0 | 1 | 0 | |
| Medium-Low (2.5-5 mg/d) | 0 | 0 | 0 | 1 | |
| None | 0 | 0 | 0 | 0 | |
| SEX | F | 1 | |||
| M | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27652 | 717 | 26935 | 97.41 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 26828.495 | 26078.925 |
| AIC | 26828.495 | 26106.925 |
| SBC | 26828.495 | 26170.976 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 749.5696 | 14 | <.0001 |
| Score (Model-Based) | 1060.4860 | 14 | <.0001 |
| Score (Sandwich) | 78.3799 | 14 | <.0001 |
| Wald (Model-Based) | 868.3221 | 14 | <.0001 |
| Wald (Sandwich) | 200.3448 | 14 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 10.5168 | 0.0052 |
| database | 2 | 8.6311 | 0.0134 |
| exposure*database | 4 | 9.7296 | 0.0452 |
| meanPredEqDoseCat | 4 | 5.0102 | 0.2863 |
| SEX | 1 | 5.0315 | 0.0249 |
| indHospInf | 1 | 4.5175 | 0.0335 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | 0.29210 | 0.35935 | 3.572 | 0.6608 | 0.4163 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | -0.66658 | 0.25213 | 3.862 | 6.9895 | 0.0082 | exposure No exposure | ||||
| database | MPCD | 1 | -0.27996 | 0.78655 | 6.231 | 0.1267 | 0.7219 | database MPCD | ||||
| database | Marketscan | 1 | -1.03860 | 0.36249 | 3.314 | 8.2091 | 0.0042 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | -0.75936 | 0.94236 | 1.749 | 0.6493 | 0.4204 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | -0.55861 | 0.52142 | 1.540 | 1.1477 | 0.2840 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 0.27064 | 0.72319 | 2.782 | 0.1400 | 0.7082 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.63759 | 0.37280 | 1.935 | 2.9251 | 0.0872 | exposure No exposure * database Marketscan | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | -0.45882 | 0.80609 | 1.162 | 0.3240 | 0.5692 | 0.632 | 0.130 | 3.068 | meanPredEqDoseCat High (10+ mg/d) | |
| meanPredEqDoseCat | Low (<2.5 mg/d) | 1 | 0.48451 | 0.27928 | 4.764 | 3.0096 | 0.0828 | 1.623 | 0.939 | 2.806 | meanPredEqDoseCat Low (<2.5 mg/d) | |
| meanPredEqDoseCat | Medium-High (5-10 mg/d) | 1 | -0.09367 | 0.39628 | 2.253 | 0.0559 | 0.8132 | 0.911 | 0.419 | 1.980 | meanPredEqDoseCat Medium-High (5-10 mg/d) | |
| meanPredEqDoseCat | Medium-Low (2.5-5 mg/d) | 1 | 0.33369 | 0.32917 | 2.826 | 1.0276 | 0.3107 | 1.396 | 0.732 | 2.661 | meanPredEqDoseCat Medium-Low (2.5-5 mg/d) | |
| SEX | F | 1 | -0.57361 | 0.25572 | 4.798 | 5.0315 | 0.0249 | 0.563 | 0.341 | 0.930 | Administrative Sex F | |
| indHospInf | 1 | 1.43045 | 0.67301 | 6.967 | 4.5175 | 0.0335 | 4.181 | 1.118 | 15.635 |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 0.627 | 0.107 | 3.685 |
| exposure No exposure vs TNF At database=MPCD | 0.673 | 0.161 | 2.819 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.766 | 0.341 | 1.719 |
| exposure No exposure vs TNF At database=Marketscan | 0.971 | 0.543 | 1.738 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 1.339 | 0.662 | 2.709 |
| exposure No exposure vs TNF At database=Medicare | 0.513 | 0.313 | 0.842 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptwStabilized |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||||
|---|---|---|---|---|---|
| Class | Value | Design Variables | |||
| exposure | DMARD or NSAID | 1 | 0 | ||
| No exposure | 0 | 1 | |||
| TNF | 0 | 0 | |||
| database | MPCD | 1 | 0 | ||
| Marketscan | 0 | 1 | |||
| Medicare | 0 | 0 | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 0 | 0 | 0 |
| Low (<2.5 mg/d) | 0 | 1 | 0 | 0 | |
| Medium-High (5-10 mg/d) | 0 | 0 | 1 | 0 | |
| Medium-Low (2.5-5 mg/d) | 0 | 0 | 0 | 1 | |
| None | 0 | 0 | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27652 | 717 | 26935 | 97.41 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 2863.106 | 2781.790 |
| AIC | 2863.106 | 2805.790 |
| SBC | 2863.106 | 2860.691 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 81.3161 | 12 | <.0001 |
| Score (Model-Based) | 87.3687 | 12 | <.0001 |
| Score (Sandwich) | 77.8454 | 12 | <.0001 |
| Wald (Model-Based) | 81.4100 | 12 | <.0001 |
| Wald (Sandwich) | 172.3925 | 12 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 49.9162 | <.0001 |
| database | 2 | 7.4257 | 0.0244 |
| exposure*database | 4 | 18.6822 | 0.0009 |
| meanPredEqDoseCat | 4 | 14.9618 | 0.0048 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | 0.39874 | 0.31312 | 0.727 | 1.6216 | 0.2029 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | -0.97238 | 0.24297 | 0.841 | 16.0166 | <.0001 | exposure No exposure | ||||
| database | MPCD | 1 | -0.35994 | 0.68789 | 3.258 | 0.2738 | 0.6008 | database MPCD | ||||
| database | Marketscan | 1 | -1.05966 | 0.42312 | 2.129 | 6.2718 | 0.0123 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | -0.73094 | 0.79268 | 0.635 | 0.8503 | 0.3565 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | -0.63757 | 0.49819 | 0.645 | 1.6378 | 0.2006 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 0.62401 | 0.54867 | 0.769 | 1.2935 | 0.2554 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.86207 | 0.38748 | 0.841 | 4.9498 | 0.0261 | exposure No exposure * database Marketscan | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | -1.82587 | 0.83626 | 0.239 | 4.7671 | 0.0290 | 0.161 | 0.031 | 0.830 | meanPredEqDoseCat High (10+ mg/d) | |
| meanPredEqDoseCat | Low (<2.5 mg/d) | 1 | 0.86565 | 0.33671 | 2.272 | 6.6096 | 0.0101 | 2.377 | 1.228 | 4.598 | meanPredEqDoseCat Low (<2.5 mg/d) | |
| meanPredEqDoseCat | Medium-High (5-10 mg/d) | 1 | -0.34405 | 0.65418 | 1.046 | 0.2766 | 0.5989 | 0.709 | 0.197 | 2.555 | meanPredEqDoseCat Medium-High (5-10 mg/d) | |
| meanPredEqDoseCat | Medium-Low (2.5-5 mg/d) | 1 | 0.62467 | 0.51373 | 1.659 | 1.4785 | 0.2240 | 1.868 | 0.682 | 5.112 | meanPredEqDoseCat Medium-Low (2.5-5 mg/d) |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 0.717 | 0.168 | 3.063 |
| exposure No exposure vs TNF At database=MPCD | 0.706 | 0.246 | 2.023 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.788 | 0.349 | 1.777 |
| exposure No exposure vs TNF At database=Marketscan | 0.896 | 0.496 | 1.618 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 1.490 | 0.807 | 2.752 |
| exposure No exposure vs TNF At database=Medicare | 0.378 | 0.235 | 0.609 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 26525 | 1340 | 25185 | 94.95 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 25116.662 | 24490.718 |
| AIC | 25116.662 | 24506.718 |
| SBC | 25116.662 | 24548.321 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 625.9444 | 8 | <.0001 |
| Score (Model-Based) | 614.9008 | 8 | <.0001 |
| Score (Sandwich) | 515.2337 | 8 | <.0001 |
| Wald (Model-Based) | 507.4413 | 8 | <.0001 |
| Wald (Sandwich) | 469.8952 | 8 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 111.1546 | <.0001 |
| database | 2 | 58.3015 | <.0001 |
| exposure*database | 4 | 9.2121 | 0.0560 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -0.38998 | 0.17888 | 0.988 | 4.7527 | 0.0293 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | 0.57105 | 0.16516 | 0.993 | 11.9552 | 0.0005 | exposure No exposure | ||||
| database | MPCD | 1 | -1.77166 | 0.38786 | 0.997 | 20.8642 | <.0001 | database MPCD | ||||
| database | Marketscan | 1 | -1.55364 | 0.21514 | 0.991 | 52.1509 | <.0001 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 0.99021 | 0.49635 | 0.995 | 3.9800 | 0.0460 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | 0.60892 | 0.27623 | 0.993 | 4.8594 | 0.0275 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 1.02957 | 0.40887 | 0.998 | 6.3407 | 0.0118 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.39209 | 0.23745 | 0.994 | 2.7265 | 0.0987 | exposure No exposure * database Marketscan |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 1.823 | 0.734 | 4.523 |
| exposure No exposure vs TNF At database=MPCD | 4.956 | 2.379 | 10.326 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 1.245 | 0.823 | 1.882 |
| exposure No exposure vs TNF At database=Marketscan | 2.620 | 1.872 | 3.666 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.677 | 0.477 | 0.961 |
| exposure No exposure vs TNF At database=Medicare | 1.770 | 1.281 | 2.447 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 26525 | 1340 | 25185 | 94.95 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 52478.212 | 51242.103 |
| AIC | 52478.212 | 51258.103 |
| SBC | 52478.212 | 51299.707 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 1236.1090 | 8 | <.0001 |
| Score (Model-Based) | 1172.4192 | 8 | <.0001 |
| Score (Sandwich) | 225.6995 | 8 | <.0001 |
| Wald (Model-Based) | 948.0269 | 8 | <.0001 |
| Wald (Sandwich) | 238.8609 | 8 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 59.2050 | <.0001 |
| database | 2 | 35.4230 | <.0001 |
| exposure*database | 4 | 6.6911 | 0.1531 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -0.60351 | 0.23731 | 2.810 | 6.4673 | 0.0110 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | 0.30009 | 0.21539 | 4.569 | 1.9411 | 0.1635 | exposure No exposure | ||||
| database | MPCD | 1 | -2.18440 | 0.61445 | 3.509 | 12.6384 | 0.0004 | database MPCD | ||||
| database | Marketscan | 1 | -1.56509 | 0.28216 | 3.650 | 30.7682 | <.0001 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 1.13798 | 0.68778 | 1.958 | 2.7376 | 0.0980 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | 0.49998 | 0.33032 | 1.869 | 2.2911 | 0.1301 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 1.41257 | 0.62821 | 2.928 | 5.0561 | 0.0245 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.39939 | 0.29666 | 2.484 | 1.8124 | 0.1782 | exposure No exposure * database Marketscan |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 1.707 | 0.475 | 6.131 |
| exposure No exposure vs TNF At database=MPCD | 5.544 | 1.750 | 17.566 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.902 | 0.560 | 1.453 |
| exposure No exposure vs TNF At database=Marketscan | 2.013 | 1.345 | 3.011 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.547 | 0.343 | 0.871 |
| exposure No exposure vs TNF At database=Medicare | 1.350 | 0.885 | 2.059 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||||
|---|---|---|---|---|---|
| Class | Value | Design Variables | |||
| exposure | DMARD or NSAID | 1 | 0 | ||
| No exposure | 0 | 1 | |||
| TNF | 0 | 0 | |||
| database | MPCD | 1 | 0 | ||
| Marketscan | 0 | 1 | |||
| Medicare | 0 | 0 | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 0 | 0 | 0 |
| Low (<2.5 mg/d) | 0 | 1 | 0 | 0 | |
| Medium-High (5-10 mg/d) | 0 | 0 | 1 | 0 | |
| Medium-Low (2.5-5 mg/d) | 0 | 0 | 0 | 1 | |
| None | 0 | 0 | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 26525 | 1340 | 25185 | 94.95 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 52478.212 | 51168.965 |
| AIC | 52478.212 | 51192.965 |
| SBC | 52478.212 | 51255.370 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 1309.2473 | 12 | <.0001 |
| Score (Model-Based) | 1240.2170 | 12 | <.0001 |
| Score (Sandwich) | 229.6443 | 12 | <.0001 |
| Wald (Model-Based) | 1014.6018 | 12 | <.0001 |
| Wald (Sandwich) | 242.8906 | 12 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 56.3160 | <.0001 |
| database | 2 | 35.4600 | <.0001 |
| exposure*database | 4 | 6.4474 | 0.1681 |
| meanPredEqDoseCat | 4 | 7.2979 | 0.1210 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -0.59934 | 0.23603 | 2.794 | 6.4476 | 0.0111 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | 0.28025 | 0.21921 | 4.646 | 1.6344 | 0.2011 | exposure No exposure | ||||
| database | MPCD | 1 | -2.17791 | 0.61497 | 3.511 | 12.5420 | 0.0004 | database MPCD | ||||
| database | Marketscan | 1 | -1.56309 | 0.28213 | 3.648 | 30.6957 | <.0001 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 1.14861 | 0.69106 | 1.967 | 2.7626 | 0.0965 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | 0.51507 | 0.33234 | 1.881 | 2.4020 | 0.1212 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 1.36297 | 0.62347 | 2.904 | 4.7790 | 0.0288 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.38389 | 0.29400 | 2.462 | 1.7051 | 0.1916 | exposure No exposure * database Marketscan | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | -0.87966 | 0.63325 | 1.440 | 1.9297 | 0.1648 | 0.415 | 0.120 | 1.435 | meanPredEqDoseCat High (10+ mg/d) | |
| meanPredEqDoseCat | Low (<2.5 mg/d) | 1 | -0.40581 | 0.16416 | 3.043 | 6.1109 | 0.0134 | 0.666 | 0.483 | 0.919 | meanPredEqDoseCat Low (<2.5 mg/d) | |
| meanPredEqDoseCat | Medium-High (5-10 mg/d) | 1 | -0.36033 | 0.32858 | 2.244 | 1.2026 | 0.2728 | 0.697 | 0.366 | 1.328 | meanPredEqDoseCat Medium-High (5-10 mg/d) | |
| meanPredEqDoseCat | Medium-Low (2.5-5 mg/d) | 1 | -0.26837 | 0.28390 | 2.904 | 0.8936 | 0.3445 | 0.765 | 0.438 | 1.334 | meanPredEqDoseCat Medium-Low (2.5-5 mg/d) |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 1.732 | 0.479 | 6.267 |
| exposure No exposure vs TNF At database=MPCD | 5.172 | 1.637 | 16.336 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.919 | 0.570 | 1.481 |
| exposure No exposure vs TNF At database=Marketscan | 1.943 | 1.297 | 2.910 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.549 | 0.346 | 0.872 |
| exposure No exposure vs TNF At database=Medicare | 1.323 | 0.861 | 2.034 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 | |
| SEX | F | 1 | |
| M | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 26525 | 1340 | 25185 | 94.95 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 52478.212 | 51020.676 |
| AIC | 52478.212 | 51038.676 |
| SBC | 52478.212 | 51085.480 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 1457.5359 | 9 | <.0001 |
| Score (Model-Based) | 1397.8011 | 9 | <.0001 |
| Score (Sandwich) | 230.3120 | 9 | <.0001 |
| Wald (Model-Based) | 1171.1023 | 9 | <.0001 |
| Wald (Sandwich) | 249.9248 | 9 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 61.2585 | <.0001 |
| database | 2 | 35.5996 | <.0001 |
| exposure*database | 4 | 5.8671 | 0.2093 |
| SEX | 1 | 11.9034 | 0.0006 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -0.48646 | 0.23438 | 2.762 | 4.3078 | 0.0379 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | 0.40893 | 0.21119 | 4.441 | 3.7492 | 0.0528 | exposure No exposure | ||||
| database | MPCD | 1 | -2.20247 | 0.61583 | 3.517 | 12.7910 | 0.0003 | database MPCD | ||||
| database | Marketscan | 1 | -1.57090 | 0.28275 | 3.657 | 30.8660 | <.0001 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 1.06018 | 0.68604 | 1.953 | 2.3881 | 0.1223 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | 0.42361 | 0.32810 | 1.856 | 1.6669 | 0.1967 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 1.32483 | 0.62530 | 2.914 | 4.4889 | 0.0341 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.28677 | 0.29259 | 2.446 | 0.9606 | 0.3270 | exposure No exposure * database Marketscan | |||
| SEX | F | 1 | -0.59696 | 0.17302 | 4.315 | 11.9034 | 0.0006 | 0.550 | 0.392 | 0.773 | Administrative Sex F |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 1.775 | 0.492 | 6.404 |
| exposure No exposure vs TNF At database=MPCD | 5.662 | 1.782 | 17.993 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.939 | 0.582 | 1.516 |
| exposure No exposure vs TNF At database=Marketscan | 2.005 | 1.340 | 3.001 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.615 | 0.388 | 0.973 |
| exposure No exposure vs TNF At database=Medicare | 1.505 | 0.995 | 2.277 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 26525 | 1340 | 25185 | 94.95 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 52478.212 | 51186.445 |
| AIC | 52478.212 | 51204.445 |
| SBC | 52478.212 | 51251.249 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 1291.7674 | 9 | <.0001 |
| Score (Model-Based) | 1220.8469 | 9 | <.0001 |
| Score (Sandwich) | 230.3840 | 9 | <.0001 |
| Wald (Model-Based) | 984.7396 | 9 | <.0001 |
| Wald (Sandwich) | 244.7130 | 9 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 46.3549 | <.0001 |
| database | 2 | 36.3211 | <.0001 |
| exposure*database | 4 | 7.0449 | 0.1335 |
| indHospInf | 1 | 11.2044 | 0.0008 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -0.53206 | 0.23309 | 2.752 | 5.2103 | 0.0225 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | 0.26331 | 0.21737 | 4.603 | 1.4673 | 0.2258 | exposure No exposure | ||||
| database | MPCD | 1 | -2.22211 | 0.61535 | 3.513 | 13.0404 | 0.0003 | database MPCD | ||||
| database | Marketscan | 1 | -1.59342 | 0.28353 | 3.666 | 31.5837 | <.0001 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 1.06830 | 0.68652 | 1.954 | 2.4215 | 0.1197 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | 0.43501 | 0.32835 | 1.857 | 1.7551 | 0.1852 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 1.44863 | 0.62890 | 2.931 | 5.3057 | 0.0213 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.42645 | 0.29764 | 2.492 | 2.0529 | 0.1519 | exposure No exposure * database Marketscan | |||
| indHospInf | 1 | -1.18551 | 0.35417 | 1.824 | 11.2044 | 0.0008 | 0.306 | 0.153 | 0.612 |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 1.710 | 0.476 | 6.142 |
| exposure No exposure vs TNF At database=MPCD | 5.540 | 1.748 | 17.554 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.908 | 0.563 | 1.462 |
| exposure No exposure vs TNF At database=Marketscan | 1.993 | 1.332 | 2.982 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.587 | 0.372 | 0.928 |
| exposure No exposure vs TNF At database=Medicare | 1.301 | 0.850 | 1.992 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||||
|---|---|---|---|---|---|
| Class | Value | Design Variables | |||
| exposure | DMARD or NSAID | 1 | 0 | ||
| No exposure | 0 | 1 | |||
| TNF | 0 | 0 | |||
| database | MPCD | 1 | 0 | ||
| Marketscan | 0 | 1 | |||
| Medicare | 0 | 0 | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 0 | 0 | 0 |
| Low (<2.5 mg/d) | 0 | 1 | 0 | 0 | |
| Medium-High (5-10 mg/d) | 0 | 0 | 1 | 0 | |
| Medium-Low (2.5-5 mg/d) | 0 | 0 | 0 | 1 | |
| None | 0 | 0 | 0 | 0 | |
| SEX | F | 1 | |||
| M | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 26525 | 1340 | 25185 | 94.95 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 52478.212 | 50924.146 |
| AIC | 52478.212 | 50952.146 |
| SBC | 52478.212 | 51024.952 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 1554.0665 | 14 | <.0001 |
| Score (Model-Based) | 1482.7534 | 14 | <.0001 |
| Score (Sandwich) | 238.0263 | 14 | <.0001 |
| Wald (Model-Based) | 1242.5390 | 14 | <.0001 |
| Wald (Sandwich) | 258.1390 | 14 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 46.2791 | <.0001 |
| database | 2 | 36.5559 | <.0001 |
| exposure*database | 4 | 5.7855 | 0.2158 |
| meanPredEqDoseCat | 4 | 5.5673 | 0.2339 |
| SEX | 1 | 10.5181 | 0.0012 |
| indHospInf | 1 | 9.2413 | 0.0024 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -0.41762 | 0.22946 | 2.693 | 3.3125 | 0.0688 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | 0.36249 | 0.21630 | 4.526 | 2.8086 | 0.0938 | exposure No exposure | ||||
| database | MPCD | 1 | -2.23080 | 0.61771 | 3.526 | 13.0421 | 0.0003 | database MPCD | ||||
| database | Marketscan | 1 | -1.58698 | 0.28232 | 3.648 | 31.5980 | <.0001 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 1.01689 | 0.69004 | 1.964 | 2.1717 | 0.1406 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | 0.37609 | 0.32805 | 1.854 | 1.3143 | 0.2516 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 1.32137 | 0.62232 | 2.898 | 4.5084 | 0.0337 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.29814 | 0.29116 | 2.432 | 1.0485 | 0.3059 | exposure No exposure * database Marketscan | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | -0.73613 | 0.61141 | 1.390 | 1.4496 | 0.2286 | 0.479 | 0.145 | 1.588 | meanPredEqDoseCat High (10+ mg/d) | |
| meanPredEqDoseCat | Low (<2.5 mg/d) | 1 | -0.34743 | 0.16189 | 2.995 | 4.6058 | 0.0319 | 0.707 | 0.514 | 0.970 | meanPredEqDoseCat Low (<2.5 mg/d) | |
| meanPredEqDoseCat | Medium-High (5-10 mg/d) | 1 | -0.28315 | 0.31762 | 2.169 | 0.7947 | 0.3727 | 0.753 | 0.404 | 1.404 | meanPredEqDoseCat Medium-High (5-10 mg/d) | |
| meanPredEqDoseCat | Medium-Low (2.5-5 mg/d) | 1 | -0.14612 | 0.27220 | 2.776 | 0.2882 | 0.5914 | 0.864 | 0.507 | 1.473 | meanPredEqDoseCat Medium-Low (2.5-5 mg/d) | |
| SEX | F | 1 | -0.56228 | 0.17337 | 4.295 | 10.5181 | 0.0012 | 0.570 | 0.406 | 0.801 | Administrative Sex F | |
| indHospInf | 1 | -1.06460 | 0.35020 | 1.799 | 9.2413 | 0.0024 | 0.345 | 0.174 | 0.685 |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 1.821 | 0.500 | 6.631 |
| exposure No exposure vs TNF At database=MPCD | 5.386 | 1.697 | 17.095 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.959 | 0.595 | 1.548 |
| exposure No exposure vs TNF At database=Marketscan | 1.936 | 1.292 | 2.901 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.659 | 0.420 | 1.033 |
| exposure No exposure vs TNF At database=Medicare | 1.437 | 0.940 | 2.196 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptwStabilized |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||||
|---|---|---|---|---|---|
| Class | Value | Design Variables | |||
| exposure | DMARD or NSAID | 1 | 0 | ||
| No exposure | 0 | 1 | |||
| TNF | 0 | 0 | |||
| database | MPCD | 1 | 0 | ||
| Marketscan | 0 | 1 | |||
| Medicare | 0 | 0 | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 0 | 0 | 0 |
| Low (<2.5 mg/d) | 0 | 1 | 0 | 0 | |
| Medium-High (5-10 mg/d) | 0 | 0 | 1 | 0 | |
| Medium-Low (2.5-5 mg/d) | 0 | 0 | 0 | 1 | |
| None | 0 | 0 | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 26525 | 1340 | 25185 | 94.95 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 5661.903 | 5464.919 |
| AIC | 5661.903 | 5488.919 |
| SBC | 5661.903 | 5551.324 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 196.9847 | 12 | <.0001 |
| Score (Model-Based) | 239.3356 | 12 | <.0001 |
| Score (Sandwich) | 165.6947 | 12 | <.0001 |
| Wald (Model-Based) | 194.0443 | 12 | <.0001 |
| Wald (Sandwich) | 153.9203 | 12 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 28.8922 | <.0001 |
| database | 2 | 33.8131 | <.0001 |
| exposure*database | 4 | 7.1281 | 0.1293 |
| meanPredEqDoseCat | 4 | 1.6025 | 0.8083 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -0.55558 | 0.24346 | 0.648 | 5.2076 | 0.0225 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | 0.22164 | 0.22012 | 1.051 | 1.0139 | 0.3140 | exposure No exposure | ||||
| database | MPCD | 1 | -2.16138 | 0.61680 | 2.359 | 12.2792 | 0.0005 | database MPCD | ||||
| database | Marketscan | 1 | -1.53819 | 0.28632 | 2.041 | 28.8605 | <.0001 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 1.13418 | 0.69711 | 0.873 | 2.6470 | 0.1037 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | 0.49268 | 0.33484 | 0.697 | 2.1649 | 0.1412 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 1.42688 | 0.62090 | 1.331 | 5.2812 | 0.0216 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.43876 | 0.29411 | 0.993 | 2.2255 | 0.1358 | exposure No exposure * database Marketscan | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | -0.43211 | 0.95281 | 0.955 | 0.2057 | 0.6502 | 0.649 | 0.100 | 4.201 | meanPredEqDoseCat High (10+ mg/d) | |
| meanPredEqDoseCat | Low (<2.5 mg/d) | 1 | -0.24176 | 0.23736 | 1.686 | 1.0374 | 0.3084 | 0.785 | 0.493 | 1.250 | meanPredEqDoseCat Low (<2.5 mg/d) | |
| meanPredEqDoseCat | Medium-High (5-10 mg/d) | 1 | -0.24487 | 0.42497 | 1.028 | 0.3320 | 0.5645 | 0.783 | 0.340 | 1.800 | meanPredEqDoseCat Medium-High (5-10 mg/d) | |
| meanPredEqDoseCat | Medium-Low (2.5-5 mg/d) | 1 | -0.28560 | 0.36672 | 1.287 | 0.6065 | 0.4361 | 0.752 | 0.366 | 1.542 | meanPredEqDoseCat Medium-Low (2.5-5 mg/d) |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 1.784 | 0.481 | 6.618 |
| exposure No exposure vs TNF At database=MPCD | 5.199 | 1.682 | 16.076 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.939 | 0.580 | 1.520 |
| exposure No exposure vs TNF At database=Marketscan | 1.936 | 1.286 | 2.913 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.574 | 0.356 | 0.925 |
| exposure No exposure vs TNF At database=Medicare | 1.248 | 0.811 | 1.921 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27073 | 760 | 26313 | 97.19 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 13932.798 | 13494.922 |
| AIC | 13932.798 | 13510.922 |
| SBC | 13932.798 | 13547.989 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 437.8760 | 8 | <.0001 |
| Score (Model-Based) | 402.4109 | 8 | <.0001 |
| Score (Sandwich) | 369.6531 | 8 | <.0001 |
| Wald (Model-Based) | 304.7009 | 8 | <.0001 |
| Wald (Sandwich) | 290.2216 | 8 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 44.7432 | <.0001 |
| database | 2 | 42.0366 | <.0001 |
| exposure*database | 4 | 2.1500 | 0.7082 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -0.33987 | 0.22672 | 0.991 | 2.2473 | 0.1338 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | 0.44680 | 0.20967 | 1.001 | 4.5411 | 0.0331 | exposure No exposure | ||||
| database | MPCD | 1 | -1.93658 | 0.53985 | 1.000 | 12.8683 | 0.0003 | database MPCD | ||||
| database | Marketscan | 1 | -1.80886 | 0.29430 | 0.997 | 37.7762 | <.0001 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 0.41380 | 0.79685 | 1.000 | 0.2697 | 0.6036 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | -0.23225 | 0.47120 | 0.999 | 0.2429 | 0.6221 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 0.68603 | 0.58226 | 1.000 | 1.3882 | 0.2387 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.10987 | 0.34022 | 0.998 | 0.1043 | 0.7467 | exposure No exposure * database Marketscan |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 1.077 | 0.241 | 4.814 |
| exposure No exposure vs TNF At database=MPCD | 3.104 | 1.069 | 9.013 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.564 | 0.251 | 1.270 |
| exposure No exposure vs TNF At database=Marketscan | 1.745 | 1.030 | 2.957 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.712 | 0.456 | 1.110 |
| exposure No exposure vs TNF At database=Medicare | 1.563 | 1.037 | 2.358 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27073 | 760 | 26313 | 97.19 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 28659.735 | 27809.940 |
| AIC | 28659.735 | 27825.940 |
| SBC | 28659.735 | 27863.006 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 849.7954 | 8 | <.0001 |
| Score (Model-Based) | 750.2625 | 8 | <.0001 |
| Score (Sandwich) | 177.1901 | 8 | <.0001 |
| Wald (Model-Based) | 546.9862 | 8 | <.0001 |
| Wald (Sandwich) | 170.1370 | 8 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 12.2768 | 0.0022 |
| database | 2 | 31.5817 | <.0001 |
| exposure*database | 4 | 5.0931 | 0.2779 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -0.40092 | 0.30965 | 2.864 | 1.6764 | 0.1954 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | 0.20114 | 0.28974 | 4.818 | 0.4819 | 0.4876 | exposure No exposure | ||||
| database | MPCD | 1 | -2.67073 | 0.64516 | 2.176 | 17.1367 | <.0001 | database MPCD | ||||
| database | Marketscan | 1 | -1.89391 | 0.38372 | 3.211 | 24.3614 | <.0001 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 1.14550 | 0.87669 | 1.471 | 1.7072 | 0.1913 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | -0.11771 | 0.54700 | 1.610 | 0.0463 | 0.8296 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 1.43781 | 0.68349 | 1.892 | 4.4253 | 0.0354 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.22798 | 0.41713 | 2.121 | 0.2987 | 0.5847 | exposure No exposure * database Marketscan |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 2.106 | 0.418 | 10.596 |
| exposure No exposure vs TNF At database=MPCD | 5.150 | 1.524 | 17.401 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.595 | 0.243 | 1.461 |
| exposure No exposure vs TNF At database=Marketscan | 1.536 | 0.836 | 2.822 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.670 | 0.365 | 1.229 |
| exposure No exposure vs TNF At database=Medicare | 1.223 | 0.693 | 2.158 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||||
|---|---|---|---|---|---|
| Class | Value | Design Variables | |||
| exposure | DMARD or NSAID | 1 | 0 | ||
| No exposure | 0 | 1 | |||
| TNF | 0 | 0 | |||
| database | MPCD | 1 | 0 | ||
| Marketscan | 0 | 1 | |||
| Medicare | 0 | 0 | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 0 | 0 | 0 |
| Low (<2.5 mg/d) | 0 | 1 | 0 | 0 | |
| Medium-High (5-10 mg/d) | 0 | 0 | 1 | 0 | |
| Medium-Low (2.5-5 mg/d) | 0 | 0 | 0 | 1 | |
| None | 0 | 0 | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27073 | 760 | 26313 | 97.19 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 28659.735 | 27793.657 |
| AIC | 28659.735 | 27817.657 |
| SBC | 28659.735 | 27873.257 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 866.0780 | 12 | <.0001 |
| Score (Model-Based) | 766.3027 | 12 | <.0001 |
| Score (Sandwich) | 185.8605 | 12 | <.0001 |
| Wald (Model-Based) | 562.2222 | 12 | <.0001 |
| Wald (Sandwich) | 175.0573 | 12 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 11.7693 | 0.0028 |
| database | 2 | 31.4688 | <.0001 |
| exposure*database | 4 | 4.8589 | 0.3021 |
| meanPredEqDoseCat | 4 | 4.4736 | 0.3457 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -0.39697 | 0.30773 | 2.845 | 1.6641 | 0.1971 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | 0.19244 | 0.29415 | 4.888 | 0.4280 | 0.5130 | exposure No exposure | ||||
| database | MPCD | 1 | -2.66058 | 0.64536 | 2.177 | 16.9962 | <.0001 | database MPCD | ||||
| database | Marketscan | 1 | -1.89514 | 0.38440 | 3.215 | 24.3066 | <.0001 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 1.13462 | 0.87697 | 1.472 | 1.6739 | 0.1957 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | -0.11392 | 0.54782 | 1.613 | 0.0432 | 0.8353 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 1.40179 | 0.67967 | 1.881 | 4.2537 | 0.0392 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.22020 | 0.41572 | 2.113 | 0.2806 | 0.5963 | exposure No exposure * database Marketscan | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | -0.34137 | 0.68087 | 1.438 | 0.2514 | 0.6161 | 0.711 | 0.187 | 2.700 | meanPredEqDoseCat High (10+ mg/d) | |
| meanPredEqDoseCat | Low (<2.5 mg/d) | 1 | -0.13933 | 0.27355 | 4.048 | 0.2594 | 0.6105 | 0.870 | 0.509 | 1.487 | meanPredEqDoseCat Low (<2.5 mg/d) | |
| meanPredEqDoseCat | Medium-High (5-10 mg/d) | 1 | 0.06849 | 0.33630 | 2.032 | 0.0415 | 0.8386 | 1.071 | 0.554 | 2.070 | meanPredEqDoseCat Medium-High (5-10 mg/d) | |
| meanPredEqDoseCat | Medium-Low (2.5-5 mg/d) | 1 | -0.48695 | 0.25872 | 1.741 | 3.5424 | 0.0598 | 0.614 | 0.370 | 1.020 | meanPredEqDoseCat Medium-Low (2.5-5 mg/d) |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 2.091 | 0.415 | 10.546 |
| exposure No exposure vs TNF At database=MPCD | 4.925 | 1.455 | 16.672 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.600 | 0.244 | 1.473 |
| exposure No exposure vs TNF At database=Marketscan | 1.511 | 0.819 | 2.787 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.672 | 0.368 | 1.229 |
| exposure No exposure vs TNF At database=Medicare | 1.212 | 0.681 | 2.158 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 | |
| SEX | F | 1 | |
| M | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27073 | 760 | 26313 | 97.19 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 28659.735 | 27799.884 |
| AIC | 28659.735 | 27817.884 |
| SBC | 28659.735 | 27859.584 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 859.8510 | 9 | <.0001 |
| Score (Model-Based) | 760.4659 | 9 | <.0001 |
| Score (Sandwich) | 212.4726 | 9 | <.0001 |
| Wald (Model-Based) | 557.1090 | 9 | <.0001 |
| Wald (Sandwich) | 199.4051 | 9 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 12.8885 | 0.0016 |
| database | 2 | 31.5420 | <.0001 |
| exposure*database | 4 | 4.9325 | 0.2943 |
| SEX | 1 | 0.4589 | 0.4981 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -0.36802 | 0.33310 | 3.066 | 1.2207 | 0.2692 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | 0.23617 | 0.30081 | 4.923 | 0.6164 | 0.4324 | exposure No exposure | ||||
| database | MPCD | 1 | -2.67545 | 0.64495 | 2.175 | 17.2083 | <.0001 | database MPCD | ||||
| database | Marketscan | 1 | -1.89126 | 0.38483 | 3.221 | 24.1529 | <.0001 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 1.12807 | 0.87902 | 1.475 | 1.6470 | 0.1994 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | -0.13820 | 0.55342 | 1.629 | 0.0624 | 0.8028 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 1.41657 | 0.68590 | 1.898 | 4.2653 | 0.0389 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.19322 | 0.42924 | 2.179 | 0.2026 | 0.6526 | exposure No exposure * database Marketscan | |||
| SEX | F | 1 | -0.17142 | 0.25304 | 4.697 | 0.4589 | 0.4981 | 0.842 | 0.513 | 1.383 | Administrative Sex F |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 2.138 | 0.423 | 10.821 |
| exposure No exposure vs TNF At database=MPCD | 5.221 | 1.542 | 17.684 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.603 | 0.245 | 1.483 |
| exposure No exposure vs TNF At database=Marketscan | 1.536 | 0.837 | 2.821 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.692 | 0.360 | 1.330 |
| exposure No exposure vs TNF At database=Medicare | 1.266 | 0.702 | 2.284 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27073 | 760 | 26313 | 97.19 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 28659.735 | 27809.606 |
| AIC | 28659.735 | 27827.606 |
| SBC | 28659.735 | 27869.306 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 850.1290 | 9 | <.0001 |
| Score (Model-Based) | 750.6873 | 9 | <.0001 |
| Score (Sandwich) | 177.7000 | 9 | <.0001 |
| Wald (Model-Based) | 547.3392 | 9 | <.0001 |
| Wald (Sandwich) | 170.7033 | 9 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 10.6154 | 0.0050 |
| database | 2 | 30.9892 | <.0001 |
| exposure*database | 4 | 5.0468 | 0.2825 |
| indHospInf | 1 | 0.0171 | 0.8959 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -0.39367 | 0.30477 | 2.801 | 1.6685 | 0.1965 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | 0.19685 | 0.29490 | 4.870 | 0.4456 | 0.5044 | exposure No exposure | ||||
| database | MPCD | 1 | -2.67534 | 0.64828 | 2.186 | 17.0307 | <.0001 | database MPCD | ||||
| database | Marketscan | 1 | -1.89743 | 0.38753 | 3.239 | 23.9728 | <.0001 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 1.13822 | 0.87591 | 1.470 | 1.6886 | 0.1938 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | -0.12427 | 0.54668 | 1.608 | 0.0517 | 0.8202 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 1.44208 | 0.68594 | 1.898 | 4.4198 | 0.0355 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.23118 | 0.41981 | 2.134 | 0.3032 | 0.5819 | exposure No exposure * database Marketscan | |||
| indHospInf | 1 | -0.08732 | 0.66757 | 4.361 | 0.0171 | 0.8959 | 0.916 | 0.248 | 3.391 |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 2.105 | 0.418 | 10.596 |
| exposure No exposure vs TNF At database=MPCD | 5.150 | 1.524 | 17.401 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.596 | 0.243 | 1.461 |
| exposure No exposure vs TNF At database=Marketscan | 1.534 | 0.835 | 2.818 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.675 | 0.371 | 1.226 |
| exposure No exposure vs TNF At database=Medicare | 1.218 | 0.683 | 2.170 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||||
|---|---|---|---|---|---|
| Class | Value | Design Variables | |||
| exposure | DMARD or NSAID | 1 | 0 | ||
| No exposure | 0 | 1 | |||
| TNF | 0 | 0 | |||
| database | MPCD | 1 | 0 | ||
| Marketscan | 0 | 1 | |||
| Medicare | 0 | 0 | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 0 | 0 | 0 |
| Low (<2.5 mg/d) | 0 | 1 | 0 | 0 | |
| Medium-High (5-10 mg/d) | 0 | 0 | 1 | 0 | |
| Medium-Low (2.5-5 mg/d) | 0 | 0 | 0 | 1 | |
| None | 0 | 0 | 0 | 0 | |
| SEX | F | 1 | |||
| M | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27073 | 760 | 26313 | 97.19 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 28659.735 | 27785.540 |
| AIC | 28659.735 | 27813.540 |
| SBC | 28659.735 | 27878.407 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 874.1950 | 14 | <.0001 |
| Score (Model-Based) | 774.6415 | 14 | <.0001 |
| Score (Sandwich) | 221.5841 | 14 | <.0001 |
| Wald (Model-Based) | 570.4499 | 14 | <.0001 |
| Wald (Sandwich) | 204.9202 | 14 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 10.4046 | 0.0055 |
| database | 2 | 30.9037 | <.0001 |
| exposure*database | 4 | 4.6759 | 0.3222 |
| meanPredEqDoseCat | 4 | 4.0269 | 0.4024 |
| SEX | 1 | 0.3441 | 0.5575 |
| indHospInf | 1 | 0.0012 | 0.9722 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -0.36432 | 0.32787 | 2.995 | 1.2347 | 0.2665 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | 0.22474 | 0.31407 | 5.092 | 0.5120 | 0.4743 | exposure No exposure | ||||
| database | MPCD | 1 | -2.66706 | 0.64734 | 2.183 | 16.9745 | <.0001 | database MPCD | ||||
| database | Marketscan | 1 | -1.89277 | 0.38884 | 3.249 | 23.6952 | <.0001 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 1.11839 | 0.87888 | 1.475 | 1.6193 | 0.2032 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | -0.13562 | 0.55459 | 1.631 | 0.0598 | 0.8068 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 1.38674 | 0.68377 | 1.892 | 4.1131 | 0.0426 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.18961 | 0.43160 | 2.190 | 0.1930 | 0.6604 | exposure No exposure * database Marketscan | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | -0.28863 | 0.69031 | 1.457 | 0.1748 | 0.6759 | 0.749 | 0.194 | 2.899 | meanPredEqDoseCat High (10+ mg/d) | |
| meanPredEqDoseCat | Low (<2.5 mg/d) | 1 | -0.12617 | 0.27341 | 4.034 | 0.2129 | 0.6445 | 0.881 | 0.516 | 1.506 | meanPredEqDoseCat Low (<2.5 mg/d) | |
| meanPredEqDoseCat | Medium-High (5-10 mg/d) | 1 | 0.08388 | 0.33337 | 2.012 | 0.0633 | 0.8013 | 1.088 | 0.566 | 2.090 | meanPredEqDoseCat Medium-High (5-10 mg/d) | |
| meanPredEqDoseCat | Medium-Low (2.5-5 mg/d) | 1 | -0.46130 | 0.26327 | 1.763 | 3.0702 | 0.0797 | 0.630 | 0.376 | 1.056 | meanPredEqDoseCat Medium-Low (2.5-5 mg/d) | |
| SEX | F | 1 | -0.15436 | 0.26313 | 4.854 | 0.3441 | 0.5575 | 0.857 | 0.512 | 1.435 | Administrative Sex F | |
| indHospInf | 1 | -0.02328 | 0.66781 | 4.335 | 0.0012 | 0.9722 | 0.977 | 0.264 | 3.617 |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 2.126 | 0.419 | 10.792 |
| exposure No exposure vs TNF At database=MPCD | 5.010 | 1.474 | 17.034 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.607 | 0.247 | 1.492 |
| exposure No exposure vs TNF At database=Marketscan | 1.513 | 0.821 | 2.790 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.695 | 0.365 | 1.321 |
| exposure No exposure vs TNF At database=Medicare | 1.252 | 0.676 | 2.317 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptwStabilized |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||||
|---|---|---|---|---|---|
| Class | Value | Design Variables | |||
| exposure | DMARD or NSAID | 1 | 0 | ||
| No exposure | 0 | 1 | |||
| TNF | 0 | 0 | |||
| database | MPCD | 1 | 0 | ||
| Marketscan | 0 | 1 | |||
| Medicare | 0 | 0 | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 0 | 0 | 0 |
| Low (<2.5 mg/d) | 0 | 1 | 0 | 0 | |
| Medium-High (5-10 mg/d) | 0 | 0 | 1 | 0 | |
| Medium-Low (2.5-5 mg/d) | 0 | 0 | 0 | 1 | |
| None | 0 | 0 | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27073 | 760 | 26313 | 97.19 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 2627.078 | 2481.909 |
| AIC | 2627.078 | 2505.909 |
| SBC | 2627.078 | 2561.508 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 145.1699 | 12 | <.0001 |
| Score (Model-Based) | 177.9751 | 12 | <.0001 |
| Score (Sandwich) | 130.1157 | 12 | <.0001 |
| Wald (Model-Based) | 130.7802 | 12 | <.0001 |
| Wald (Sandwich) | 138.1698 | 12 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 3.3490 | 0.1874 |
| database | 2 | 28.8027 | <.0001 |
| exposure*database | 4 | 5.4312 | 0.2458 |
| meanPredEqDoseCat | 4 | 13.3587 | 0.0096 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -0.31474 | 0.32793 | 0.683 | 0.9212 | 0.3372 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | 0.08355 | 0.28685 | 1.085 | 0.0848 | 0.7708 | exposure No exposure | ||||
| database | MPCD | 1 | -2.65356 | 0.65203 | 1.499 | 16.5622 | <.0001 | database MPCD | ||||
| database | Marketscan | 1 | -1.85490 | 0.40138 | 1.929 | 21.3570 | <.0001 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 1.14631 | 0.88152 | 0.676 | 1.6910 | 0.1935 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | -0.13642 | 0.55467 | 0.698 | 0.0605 | 0.8057 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 1.46086 | 0.68190 | 0.903 | 4.5896 | 0.0322 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.27791 | 0.40741 | 0.906 | 0.4653 | 0.4952 | exposure No exposure * database Marketscan | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | -1.59286 | 0.72638 | 0.291 | 4.8087 | 0.0283 | 0.203 | 0.049 | 0.844 | meanPredEqDoseCat High (10+ mg/d) | |
| meanPredEqDoseCat | Low (<2.5 mg/d) | 1 | -0.19627 | 0.33109 | 1.648 | 0.3514 | 0.5533 | 0.822 | 0.429 | 1.572 | meanPredEqDoseCat Low (<2.5 mg/d) | |
| meanPredEqDoseCat | Medium-High (5-10 mg/d) | 1 | -0.21870 | 0.46296 | 0.790 | 0.2232 | 0.6366 | 0.804 | 0.324 | 1.991 | meanPredEqDoseCat Medium-High (5-10 mg/d) | |
| meanPredEqDoseCat | Medium-Low (2.5-5 mg/d) | 1 | -1.13926 | 0.36067 | 0.592 | 9.9777 | 0.0016 | 0.320 | 0.158 | 0.649 | meanPredEqDoseCat Medium-Low (2.5-5 mg/d) |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 2.297 | 0.447 | 11.799 |
| exposure No exposure vs TNF At database=MPCD | 4.685 | 1.377 | 15.938 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.637 | 0.260 | 1.559 |
| exposure No exposure vs TNF At database=Marketscan | 1.435 | 0.758 | 2.717 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.730 | 0.384 | 1.388 |
| exposure No exposure vs TNF At database=Medicare | 1.087 | 0.620 | 1.907 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27232 | 648 | 26584 | 97.62 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 11571.757 | 11306.188 |
| AIC | 11571.757 | 11322.188 |
| SBC | 11571.757 | 11357.979 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 265.5689 | 8 | <.0001 |
| Score (Model-Based) | 225.2586 | 8 | <.0001 |
| Score (Sandwich) | 338.5171 | 8 | <.0001 |
| Wald (Model-Based) | 165.4581 | 8 | <.0001 |
| Wald (Sandwich) | 28862.5810 | 8 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 9.3919 | 0.0091 |
| database | 2 | 4957.2520 | <.0001 |
| exposure*database | 4 | 1485.8202 | <.0001 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -0.04428 | 0.25251 | 0.998 | 0.0307 | 0.8608 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | 0.31717 | 0.23451 | 0.996 | 1.8292 | 0.1762 | exposure No exposure | ||||
| database | MPCD | 1 | -13.47220 | 0.23670 | 0.001 | 3239.6289 | <.0001 | database MPCD | ||||
| database | Marketscan | 1 | -1.83002 | 0.33814 | 0.996 | 29.2898 | <.0001 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 11.65311 | 0.75236 | 0.004 | 239.8985 | <.0001 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | 0.31369 | 0.45593 | 0.996 | 0.4734 | 0.4914 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 12.18713 | 0.35410 | 0.002 | 1184.5207 | <.0001 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.65987 | 0.37393 | 0.996 | 3.1141 | 0.0776 | exposure No exposure * database Marketscan |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 110066.2 | 27280.51 | 444074.0 |
| exposure No exposure vs TNF At database=MPCD | 269493.2 | 159711.6 | 454735.8 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 1.309 | 0.622 | 2.756 |
| exposure No exposure vs TNF At database=Marketscan | 2.657 | 1.495 | 4.722 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.957 | 0.583 | 1.569 |
| exposure No exposure vs TNF At database=Medicare | 1.373 | 0.867 | 2.174 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27232 | 648 | 26584 | 97.62 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 23633.478 | 23048.826 |
| AIC | 23633.478 | 23064.826 |
| SBC | 23633.478 | 23100.617 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 584.6522 | 8 | <.0001 |
| Score (Model-Based) | 476.9012 | 8 | <.0001 |
| Score (Sandwich) | 91.8014 | 8 | <.0001 |
| Wald (Model-Based) | 299.1780 | 8 | <.0001 |
| Wald (Sandwich) | 7678.8209 | 8 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 1.2580 | 0.5331 |
| database | 2 | 2568.6583 | <.0001 |
| exposure*database | 4 | 1191.9139 | <.0001 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -0.22512 | 0.34362 | 3.050 | 0.4292 | 0.5124 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | 0.01326 | 0.31555 | 4.713 | 0.0018 | 0.9665 | exposure No exposure | ||||
| database | MPCD | 1 | -14.71985 | 0.33889 | 0.002 | 1886.6201 | <.0001 | database MPCD | ||||
| database | Marketscan | 1 | -1.68429 | 0.48293 | 3.875 | 12.1637 | 0.0005 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 12.81413 | 0.78936 | 0.006 | 263.5310 | <.0001 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | 0.04694 | 0.56463 | 1.833 | 0.0069 | 0.9337 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 13.45215 | 0.43749 | 0.003 | 945.4615 | <.0001 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.59082 | 0.49420 | 2.569 | 1.4292 | 0.2319 | exposure No exposure * database Marketscan |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 293318.1 | 69998.40 | 1229107 |
| exposure No exposure vs TNF At database=MPCD | 704613.2 | 390237.7 | 1272250 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.837 | 0.336 | 2.082 |
| exposure No exposure vs TNF At database=Marketscan | 1.830 | 0.824 | 4.060 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.798 | 0.407 | 1.566 |
| exposure No exposure vs TNF At database=Medicare | 1.013 | 0.546 | 1.881 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||||
|---|---|---|---|---|---|
| Class | Value | Design Variables | |||
| exposure | DMARD or NSAID | 1 | 0 | ||
| No exposure | 0 | 1 | |||
| TNF | 0 | 0 | |||
| database | MPCD | 1 | 0 | ||
| Marketscan | 0 | 1 | |||
| Medicare | 0 | 0 | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 0 | 0 | 0 |
| Low (<2.5 mg/d) | 0 | 1 | 0 | 0 | |
| Medium-High (5-10 mg/d) | 0 | 0 | 1 | 0 | |
| Medium-Low (2.5-5 mg/d) | 0 | 0 | 0 | 1 | |
| None | 0 | 0 | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27232 | 648 | 26584 | 97.62 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 23633.478 | 22947.067 |
| AIC | 23633.478 | 22971.067 |
| SBC | 23633.478 | 23024.754 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 686.4111 | 12 | <.0001 |
| Score (Model-Based) | 589.5475 | 12 | <.0001 |
| Score (Sandwich) | 95.3671 | 12 | <.0001 |
| Wald (Model-Based) | 409.2207 | 12 | <.0001 |
| Wald (Sandwich) | 7619.8694 | 12 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 1.5722 | 0.4556 |
| database | 2 | 2541.7611 | <.0001 |
| exposure*database | 4 | 1163.3852 | <.0001 |
| meanPredEqDoseCat | 4 | 8.0305 | 0.0905 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -0.25647 | 0.34616 | 3.075 | 0.5489 | 0.4588 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | 0.01766 | 0.32145 | 4.781 | 0.0030 | 0.9562 | exposure No exposure | ||||
| database | MPCD | 1 | -14.74537 | 0.34417 | 0.003 | 1835.5587 | <.0001 | database MPCD | ||||
| database | Marketscan | 1 | -1.70723 | 0.49027 | 3.932 | 12.1257 | 0.0005 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 12.83042 | 0.78837 | 0.006 | 264.8656 | <.0001 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | 0.04683 | 0.56281 | 1.828 | 0.0069 | 0.9337 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 13.57929 | 0.45246 | 0.003 | 900.7402 | <.0001 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.64015 | 0.50235 | 2.609 | 1.6239 | 0.2026 | exposure No exposure * database Marketscan | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | -0.53735 | 0.85403 | 1.225 | 0.3959 | 0.5292 | 0.584 | 0.110 | 3.116 | meanPredEqDoseCat High (10+ mg/d) | |
| meanPredEqDoseCat | Low (<2.5 mg/d) | 1 | 0.55756 | 0.33015 | 5.108 | 2.8522 | 0.0913 | 1.746 | 0.914 | 3.336 | meanPredEqDoseCat Low (<2.5 mg/d) | |
| meanPredEqDoseCat | Medium-High (5-10 mg/d) | 1 | -0.16186 | 0.37228 | 1.677 | 0.1890 | 0.6637 | 0.851 | 0.410 | 1.764 | meanPredEqDoseCat Medium-High (5-10 mg/d) | |
| meanPredEqDoseCat | Medium-Low (2.5-5 mg/d) | 1 | 0.75403 | 0.35734 | 3.365 | 4.4526 | 0.0348 | 2.126 | 1.055 | 4.282 | meanPredEqDoseCat Medium-Low (2.5-5 mg/d) |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 288933.1 | 68601.70 | 1216913 |
| exposure No exposure vs TNF At database=MPCD | 803671.5 | 434609.4 | 1486134 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.811 | 0.325 | 2.026 |
| exposure No exposure vs TNF At database=Marketscan | 1.931 | 0.861 | 4.331 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.774 | 0.393 | 1.525 |
| exposure No exposure vs TNF At database=Medicare | 1.018 | 0.542 | 1.911 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |