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The androgen receptor (AR) is a ligand-regulated transcription factor that stimulates cell growth and differentiation in androgen-responsive tissues. The AR N terminus contains two activation functions (AF-1a and AF-1b) that are necessary for maximal transcriptional enhancement by the receptor; however, the mechanisms ... | Androgen-insensitivity syndromes in 46,XY fetuses result in various degrees of impairment in genital virilization.1 These syndromes are caused by mutations in the androgen receptor gene that result in decreased binding of androgen to the receptor.2–9 As a consequence, the transcriptional activity of the androgen–androg... |
The aim of the study is to investigate the fibroblast growth factor receptor3 (FGFR3) expression in de novo Egyptian acute leukemia (AL) patients and to evaluate its relation with the clinical and laboratory characteristics as a potential tumorigenic marker. In this study, the level of FGFR3 gene expression was assesse... | A nested reverse transcription-PCR analysis of FGFR3 from human colorectal carcinomas revealed novel mutant transcripts caused by aberrant splicing and activation of cryptic splice sequences. Two aberrantly spliced transcripts were detected with high frequency in 50% of 36 primary tumors and in 60% of 10 human colorect... |
Soil microbial communities have remarkable capacities to cope with ceaseless environmental changes, but little is known about their adaptation potential when facing an unprecedented disturbance. We tested the effect of incremental dose of microwaving on soil bacteria as a model of unprecedented stress. 16S rRNA gene qP... | The roles of species richness, resource use, and resource availability are central to many hypotheses explaining the diversity-invasion phenomenon but are generally not investigated together. Here, we created a large diversity gradient of soil microbial communities by either assembling communities of pure bacterial str... |
Glycine is a major inhibitory neurotransmitter in the central nervous system. The postsynaptic receptor for this amino acid is a transmembrane ion channel protein which, after affinity purification on an antagonist column, contains three polypeptides of Mr 48,000, 58,000 and 93,000. Biochemical and immunological data s... | Odors are transduced by processes that modulate the membrane conductance of olfactory receptor neurons. Olfactory neurons from the aquatic salamander, Necturus maculosus, were acutely isolated without enzymes and studied with a resistive whole-cell method to minimize loss of soluble intracellular constituents. 55 of 22... |
Abstract We demonstrate a new optical technique for velocity filtering and feature extraction of time varying optical images. The technique exploits the recording of complementary (multiplexed) gratings with a relative phase shift of 180° in a photorefractive material, BSO, via a degenerate four wave mixing (DFWM) conf... | Multiple grating phenomena have been observed in a number of photorefractive systems, and interaction between such gratings has been proposed as the basis for the demonstration of interesting optical effects such as velocity filtering and image deafferentation. We are investigation grating interactions in azo-dye doped... |
In the current research, different cooling processes for getting an ultra-fast cooling rate for a hot static plain carbon steel plate are studied. Depending upon the initial surface temperature and the final microstructures of dual-phase steel, the first type of ultra-fast cooling is late ultra-fast cooling, and second... | On-line spray water cooling (OSWC) of electric-resistance-welded (ERW) steel pipes can replace the conventional off-line heat treatment process and become an important and critical procedure. The OSWC process improves production efficiency, decreases costs, and enhances the mechanical properties of ERW steel pipe, espe... |
Abstract. Two ice cores recovered from the Himalayan East Rongbuk (ER) Glacier on the northeast saddle of Mt. Qomolangma (Everest) (28°01' N, 86°58' E, 6518 m above sea level) give access to a tentative record of past Himalayan atmospheric mixing ratio of CH4 spanning the past 1200 yr. The major part of the record is a... | High-resolution records of atmospheric methane over the last 11,500 years have been obtained from two Antarctic ice cores (D47 and Byrd) and a Greenland core (Greenland Ice Core Project). These cores show similar trapping conditions for trace gases in the ice combined with a comparable sampling resolution; this togethe... |
A 16-year-old Japanese woman with infective endocarditis was admitted to hospital. An echocardiography exhibited a perivalvular pseudoaneurysm just under the mitral valve. Left ventriculography demonstrated that the aneurysm had a small neck and dyskinetic motion with oppression to the coronary sinus and right coronary... | The aim of the study was to assess the optimum timing of surgical treatment for the active phase of native valve endocarditis. A retrospective study was conducted of the records of patients who had undergone aortic and/or mitral valve replacement for active native valve endocarditis during 1979-94 at Kinki University H... |
The study presented in this report addresses the question of whether microfinance can reduce poverty. It seeks to improve understanding of the impact of microfinance services on selected non-income dimensions of poverty and emphasizes the role of assets in reducing vulnerability. The study focuses on clients from selec... | This paper contends that international Non-Governmental Organisations (NGOs) have ::: played a substantial role in developing financial services for the poor (or microfinance). Their ::: influence has been greatest in: ::: • Pursuing a broader common vision and mission, particularly towards the poorest; ::: • Offering ... |
Abstract We have previously demonstrated a decremental, oral, experienced-based control of ingestion in rat pups that is potent, diet-specific, and long lasting. This control of ingestion is revealed in the decreases in mouthing responses of rat pups to repeated oral stimulation, a phenomenon that is well described as ... | Fetal pain remains a controversial subject both in terms of recognizing its existence and the time-frame within which it appears. This article investigates the hypothesis that pain perception during development is not related to any determined structures of the central nervous system (CNS), on the contrary, the process... |
Fluorescent membrane voltage indicators that enable optical imaging of neuronal circuit operations in the living mammalian brain are powerful tools for biology and particularly neuroscience. Classical voltage-sensitive dyes, typically low molecular-weight organic compounds, have been in widespread use for decades but a... | Abstract. A major goal of the BRAIN Initiative is the development of technologies to monitor neuronal network activity during active information processing. Toward this goal, genetically encoded calcium indicator proteins have become widely used for reporting activity in preparations ranging from invertebrates to awake... |
M32 (GMICRO) series microprocessors, such as M32/100, M32/200 and M32/300, will be the first commercial 32bit microprocessors based on the TRON specification MPU. MR3210 is a realtime operating system (OS) for these microprocessors based on the ITRON2 specification. The MR3210 makes up a series of realtime OS’s with MR... | The paper presents a specification based adaptive test case generation (SBATCG) method for integration testing in an open operating system standards environment. In the SBATCG method, templates describing abstract state transitions are derived from a model based specification, and the templates are refined to the inter... |
The taxonomic status of two actinomycetes isolated from the wall of a hypogean Roman catacomb was established based on a polyphasic investigation. The organisms were found to have chemical and morphological markers typical of members of the genus Amycolatopsis. They also shared a range of chemical, molecular and phenot... | Actinomycetes have been isolated from decayed and sound stone samples taken from a tomb site at Tell Basta, Zagazig City, Egypt. A total of 160 isolates have been characterised. The numbers and distribution of actinomycetes were studied during different seasons; during the winter months (18-20 degrees C), actinomycete ... |
Tumor necrosis factor α (TNF-α) inhibitors ranked highest in German pharmaceutical expenditure in 2011. Their most important application is the treatment of rheumatoid arthritis (RA). Our objective is to analyze cost per responder of TNF-α inhibitors for RA from the German Statutory Health Insurance funds' perspective.... | Summary Background New treatment strategies for early rheumatoid arthritis are evolving rapidly. We aimed to compare addition of conventional disease-modifying antirheumatic drugs (sulfasalazine and hydroxychloroquine) with addition of a tumour necrosis factor antagonist (infliximab) to methotrexate in patients with ea... |
A multi-model and multi-level aluminum electrolytic fault prediction method is proposed. In this method, it innovatively uses the image recognition technology to predict aluminum electrolytic faults, and superimposes the chaotic neural network model to form a dual-model parallel fault prediction system for aluminum ele... | Common mechanical failures in wind turbine generators (WTGs) result in unplanned downtime, loose of production and increase the maintenance cost. Statistical studies have shown that failures due to high-speed shaft bearing (HSSB) account for 64% of all drivetrain failures. Consequently, prognostic and health management... |
PURPOSE ::: To evaluate the resolution of acute central pulmonary embolism (PE). ::: ::: ::: MATERIALS AND METHODS ::: Sixty-two patients with angiographic (n = 43) or spiral computed tomographic (CT; n = 19) diagnosis of acute central PE underwent spiral CT after a mean of 11 months. CT signs of unresolved acute or ch... | Chronic thromboembolic pulmonary hypertension (CTEPH), which has been recognised in the ::: past in no more than 0.1% patients who had undergone acute pulmonary embolism (APE), is ::: currently being found in as many as 3–8% of these patients. ::: The pathophysiology of CTEPH is not fully understood, although the relat... |
We investigated the expression of myosin subunits (myosin heavy chains) as well as light chains and the in vivo phosphorylation of the phosphorylatable myosin light chain in the heart ventricle of the adult male European hamster (Cricetus cricetus L.). Two myosin heavy chain isoenzymes could be detected under native an... | It is generally recognized that ventricular myosin regulatory light chains (RLC) are approximately 40% phosphorylated under basal conditions, and there is little change in RLC phosphorylation with agonist stimulation of myocardium or altered stimulation frequency. To establish the functional consequences of basal RLC p... |
Cardiovascular disease (CVD) disparities continue to have a negative impact on African Americans in the United States, largely because of uncontrolled hypertension. Despite the availability of evidence-based interventions, their use has not been translated into clinical and public health practice. The Johns Hopkins Cen... | Introduction. In clinical practice, end‐digit preference is a common feature of blood pressure (BP) measurements. A wider use of electronic BP measuring machines could decrease this observer‐linked artefact. The purpose of this analysis was to investigate the frequency of end‐digit preference and to evaluate the impact... |
In the mammalian retina, cone photoreceptors efficiently adapt to changing background light intensity and, therefore, are able to signal small differences in luminance between objects and backgrounds, even when the absolute intensity of the background changes over five to six orders of magnitude. Mammalian rod photorec... | The responses of rabbit rods to light were studied by drawing a single rod outer segment projecting from a small piece of retina into a glass pipette to record membrane current. The bath solution around the cells was maintained at near 40 degrees C. Light flashes evoked transient outward currents that saturated at up t... |
During a one-week short-term in-hospital period, 60 patients with chronic ventricular arrhythmias were treated with 200 mg flecainide twice a day. Flecainide reduced premature ventricular complexes (PVCs) by more than 85% without causing important side-effects in 47 patients, who entered a one-year follow-up period and... | Abstract Epicardial marker motion was measured in 14 patients before flecainide administration, immediately after an intravenous dose of 2 mg/kg over 15 minutes (maximum 150 mg) and 15 minutes thereafter. Platinum epicardial markers had been implanted more than 4 years earlier at the time of coronary artery bypass graf... |
OBJECTIVE ::: To study the hepatoprotective effect of the aerial parts and the roots of G. scabra on cute liver injury models. ::: ::: ::: METHOD ::: Acute liver injury models were induced by CCl4, TAA and D-GlanN in mice, and the levels of serum enzyme ALT, AST and AKP on acute liver injury mice with extracts of theae... | Development of anti-severe acute respiratory syndrome associated coronavirus (SARS-CoV) agents is pivotal to prevent the reemergence of the life-threatening disease, SARS. In this study, more than 200 extracts from Chinese medicinal herbs were evaluated for anti-SARS-CoV activities using a cell-based assay that measure... |
Minor modifications of the Bradford method [1976) Anal. Biochem. 72, 248-254) increase the sensitivity of the Coomassie brilliant blue G microassay for protein quantitation. This is reached by selecting the proper dye source, by alterations in the dye, ethanol, and phosphoric acid concentrations, and by including Trito... | Annexin B2 (AnxB2) is a novel member of the annexin family of Ca2+- and phospholipid-binding proteins from Cysticercus cellulosae. To obtain highly pure AnxB2 with an easy and inexpensive purification approach, its cDNA was cloned into the prokaryotic expression vector pJLA503 and the translation initiation codon was i... |
The effects of microstructure on fatigue crack growth rate and fracture mechanism have been examined for several relatively fine-grained/high dispersoid aluminium alloys. Particular attention has been paid to the behaviour of spraycast Al-Li alloys, as such materials may present novel property combinations for light we... | The texture evolution and fatigue crack propagation (FCP) of 2000 series alloys were investigated, respectively, by using scanning electron microscopy and x-ray diffraction. Results showed that the intensity change in different textures (such as Goss, Copper, S and Brass) abides by a linear evolution law, and a new mod... |
Purpose ::: ::: To demonstrate the feasibility of a four-dimensional phase contrast (PC) technique that permits spatial and temporal coverage of an entire three-dimensional volume, to quantitatively validate its accuracy against an established time resolved two-dimensional PC technique to explore advantages of the appr... | In this article a number of whole-field blood velocity measurement techniques are concisely reviewed. We primarily focus on optical measurement techniques for in vivo applications, such as laser Doppler velocimetry (including time varying speckle), laser speckle contrast imaging and particle image velocimetry (includin... |
Recommendations on social metadata features most relevant to libraries, archives, and museums and an annotated reading list of the literature the research group consulted during our research. We believe it is riskier to do nothing and become irrelevant to our user communities than to start using social media features. | Interest in user-created metadata has increased in recent years. In 2009–2010 the RLG Partner Social Metadata Working Group examined the social metadata practices of libraries, archives, and museums worldwide. They found that more than half of studied institutions improve metadata with user-created description. This ar... |
In this work, we extend recently published work for the estimation of fates of the control packets in Networked Control Systems (NCS). Unfortunately, the existing scheme is limited by the assumption that all measurement packets arrive. Moreover, a rank condition must hold, which is identical to a relative degree one as... | This paper focuses on control applications over lossy data networks. Sensor data is transmitted to an estimation-control unit over a network, and control commands are issued to subsystems over the same network. Sensor, control and acknowledgement packets may be randomly lost according to a Bernoulli process. In this co... |
As the petroleum industry advances into deep and ultradeep water exploration, special problems surge, as: low fracture gradients, high pressure loss in choke lines, overbalance drilling due to a riser safety margin, and narrow drilling window due to the existing pore pressure and fracture gradients. As a result, the we... | This printing includes corrections made since the original publication in 1986. The text presents petroleum engineering science fundamentals as well as example engineering applications involving those fundamentals. Subjects covered include rotary drilling, drilling fluids, cements, drilling hydraulics, rotary-drilling ... |
W HEN investors purchase shares of common stock, they typically acquire the right to vote in the election of the firm's board of directors and on other major issues facing the corporation. In most corporations board members are elected through "straight voting." In straight voting each shareholder is entitled to cast v... | Does a firm's corporate governance behavior affect its market value? In most empirical tests in developed countries, firm-specific corporate governance actions have little or no effect on market value. These weak results could reflect limited variation among firms in governance practices. In contrast, the corporate gov... |
Real-world, multiple-typed objects are often interconnected, forming heterogeneous information networks. A major challenge for link-based clustering in such networks is its potential to generate many different results, carrying rather diverse semantic meanings. In order to generate desired clustering, we propose to use... | In the past decade, online music streaming services (MSS), e.g., Pandora and Spotify, revolutionized the way people access, consume and share music. MSS serve users with a huge digital music library, various kinds of music discovery channels, and a number of tools for music sharing and management (e.g. bookmark, playli... |
Seed density, seed colour and the number of seed damaged by birds were monitored for several months, after a late-spring fire, in two Aleppo pine (Pinus halepensis Miller) stands growing in South Italy. In one stand (S(1)) the trees were completely burned ('charred’), in the other one (S(2)) the trees were only ‘scorch... | Fire is known to be a major factor in shaping plants and vegetation worldwide. Many plant traits have been described as adaptations for surviving fire, or regenerating after it. However, many of the traits are also advantageous for overcoming other disturbances. The fact that fire in the Mediterranean Basin has been al... |
This article outlines the major threads of controversy around the emerging subject of evolutionary psychology in the U.K. mass media during the 1990s. Much of this controversy centered on the role of evolution in shaping human gender roles and sexualities, contributing to the subject's mass appeal. This case is used to... | Since the 1930s, psychologists have used the term harem as an analogy for social relations among animals. In doing so they draw upon gendered and racial stereotypes located in the history of colonialism. We present an experimental study on the harem analogy as a means of confronting and challenging colonial undercurren... |
The hierarchy of cell function comprises at least four distinct functional levels: genome, transcriptome, proteome, and toponome. The toponome is the entirety of all protein networks traced out directly as patterns on the single cell level in the natural environment of cells in situ (e.g. tissues). In this work a photo... | This article deals with a molecular geometry imaging ::: platform capable of mapping the spatial protein-colocalisation and anti-colocalisation ::: code of large molecular systems at a time. The platform called molecular ::: unlimited systems imaging cycler (MUSIC) robotics was applied to amyotrophic ::: lateral sclero... |
Summary Protein-Protein Interaction (PPI) networks have been widely used for the task of predicting proteins involved in cancer. Previous research has shown that functional information about the protein for which a prediction is made, proximity to specific other proteins in the PPI network, as well as local network str... | BACKGROUND & AIMS ::: Neurotensin promotes inflammation and colon cancer via the neurotensin-1 receptor (NTR1). MicroRNAs (miR) regulate protein synthesis by degrading or preventing translation of mRNAs. We analyzed expression of 365 different microRNAs by human colonic epithelial cells (NCM460) after activation of NTR... |
An experimental multichannel direction finding system is presented. Measurements with two different array types show that the high-resolution MUSIC algorithm can be used to estimate the DOA (direction of arrival) of more than one source. The performance of the algorithm is not as good as simulation results due to imper... | We investigate the use of a low-cost, two-element receiving array for tracking human movements in indoor surveillance applications. Conventional direction of arrival (DOA) detection requires the use of an antenna array with multiple elements. Here we investigate the use of only two elements in the receiver array. The c... |
In this paper, the configuration of 3D (Three Dimension) location algorithm based on spherical smart antenna array with MUSIC (the multiple signal classification) DOA (Direction of Arrival) estimates is proposed to realize 3D location estimation for future mobile system. By this algorithm, the 3D location advantage gai... | Smart antenna technology is the key technique of third generation mobile communication standard TD-SCDMA. This paper presents a scheme for designing a kind of antenna array used as smart antenna for TD-SCDMA systems. Based on the design principle of adaptive antenna array and the concept of smart antenna, a uniform cir... |
A rod-like objects extraction method based on clustering is presented. Firstly, project the original point clouds onto the horizontal plane, divide them into grids, and take a single grid as data processing unit to remove the ground points; Secondly, make the grid based on processing data for point clouds detection and... | As an important component of urban vegetation, street trees play an important role in maintenance of environmental quality, aesthetic beauty of urban landscape, and social service for inhabitants. Acquiring accurate and up-to-date inventory information for street trees is required for urban horticultural planning, and ... |
Utilizing the scales theory of electromagnetic theory, the anisotropic dielectric material is reconstructed into an isotropic medium. The analytic expressions of scattering field and the scattering breadth for an anisotropic material cylinder are first presented. Their validities are checked theoretically. The influenc... | The finite difference time domain (FDTD) algorithm for transverse anisotropic medium in two dimension is proposed. The results computed by FDTD are in good agreement with the one by plane wave expansion method. This algorithm is applied successfully to compute the radar cross sections (RCS) for a conducting object part... |
BACKGROUND AND OBJECTIVES ::: This study describes and assesses the acceptability of the multiple mini interview (MMI) to both international medical graduate (IMG) applicants to family medicine residency training in Alberta, Canada, and also interviewers for Alberta's International Medical Graduate Program (AIMGP), an ... | Objectives To assess candidates’ and interviewers’ perceptions of the use of a multiple mini-interview (MMI) for selection of senior house officers (SHOs) to a UK regional paediatric training programme. ::: ::: Methods Both candidates and interviewers completed anonymous questionnaires (comprising 16 and 25 questions, ... |
The paper defines a schema in which to describe the cornucopia applied ontologies. In contradistinction to the main trend in engineering meta-ontology the main ideas that support this schema are inspired by philosophy. Namely, we look at the domain of applied ontologies from the point of view of a certain metaphilosoph... | In this article, we present an approach for ontology-based knowledge management (KM) that includes a tool suite and a methodology for developing ontology-based KM systems. It builds on the distinction between knowledge processes and knowledge metaprocesses, and is illustrated by CHAR (Corporate History AnalyzeR), a KM ... |
This article’s focus is Planet Ottakring (dir. Michael Riebl, 2015), a socially aware romantic comedy in which an alternative currency is used to free one of Vienna’s most rapidly gentrifying distr... | This paper explores some of the more extreme tendencies in the management of public space to consider whether current policy directions, in this case in central Scotland, are driven by a desire to empower or control users of such spaces. The title of the paper is taken from the theoretical lenses provided by Neil Smith... |
Since its inception in 1994, the University of the Western Cape’s Writing Centre has been on the margins, viewed as an add-on to central learning and teaching activities at the university (Archer and Richards 2011, Clarence 2011). In this article, we use the constructs of place, space, and power to explore the decenter... | In recent years universities have attempted to articulate the generic outcomes of the educational experiences they provide, beyond the content knowledge that is taught. These outcomes have come to be known as generic skills or generic graduate attributes in Australia, although they are also referred to by a range of ot... |
BACKGROUND ::: Concentrations of plasma fibrinogen, a vascular risk factor, tend to be greater in patients on peritoneal dialysis (PD) than hemodialysis (HD) therapy, like concentrations of serum cholesterol, lipoprotein(a), and transthyretin, despite the substantial loss of protein during PD. Worse vascular outcome ha... | Background:Dialysis patients have many underlying traditional and nontraditional risk factors that may predispose them to a high prevalence of cardiovascular disease. The effects of statins (eg, atorvastatin) on altering nontraditional lipoprotein measures in dialysis patients have not been extensively investigated.Obj... |
Many old damaged and undamaged building structures do not meet the criteria of modern seismic design codes. Such structures need to be seismically enhanced. The main objective of this paper is to propose and validate the effectiveness of an upgrade scheme for non-seismic buildings using steel plate shear walls (SPSW). ... | Hysteretic energy dissipation in a structure during an earthquake is the key factor, besides maximum displacement, related to the amount of damage in it. This energy demand can be accurately computed only through a nonlinear time-history analysis of the structure subjected to a specific earthquake ground acceleration. ... |
A number of recent epidemiologic observations support the need for new and broader strategies to reduce serum cholesterol levels on a population-wide basis. First, the limited data available suggest a halt in the declining incidence of coronary artery disease (CAD) in the United States since 1990, raising concerns abou... | Background—Because of rapid change in lifestyle risk factors, cardiovascular disease has become the leading cause of death in China. We sought to estimate the national levels of serum lipids and lipoproteins among the Chinese adult population. Methods and Results—We conducted a cross-sectional study in a nationally rep... |
Three schizophrenic patients who had transient recurrence of auditory hallucinations during acute dystonia precipitated by neuroleptic medication are reported. If it is accepted that psychotic symptoms result from dopaminergic overactivity, such phenomena suggest that acute dystonia might also have been caused by incre... | This report describes a patient with schizophrenia who developed episodes of ocular dystonia as a delayed side effect of neuroleptic medication. Each episode was preceded and accompanied by marked agitation, stereotypic behaviour and exacerbation of hallucinations. Both the psychotic and dystonic symptoms responded to ... |
Objetives: to determine the rate of malnutrition in patients with Crohn’s disease in our area (Substudy A). We assess in long-term the response of malnourished patients to treatment of nutritional supplement with TGF- 2 (Substudy B). Subjects: ninety-eight (51% females) patients with Crohn’s disease without selection,... | BACKGROUND/AIMS ::: To investigate the prevalence of malnutrition in patients with inflammatory bowel disease (IBD) by subjective global assessment (SGA) and the effects of oral nutritional support on the clinical parameters, consumption of energy, macronutrients and fiber intake in the Study and Control groups, prospe... |
Denosumab, a fully human monoclonal antibody to RANKL, decreases bone remodeling, increases bone density, and reduces fracture risk. This study evaluates the time course and determinants of bone turnover marker (BTM) response during denosumab treatment, the percentage of denosumab-treated women with BTMs below the prem... | The clinical applicability of bone turnover markers (BTMs) has been a reality in recent years with the accumulated experience on their performance in patients at risk of fracture and on the early prediction of the therapeutic response to anti-resorptive and anabolic drugs in osteoporosis. In addition, BTMs are also use... |
One of the most common malignancies in women is breast cancer. B-escin has pharmacological anticancer effects. 5-fluorouracil (5-FU) has antimetabolite and antiproliferative properties. The purpose of this study was to investigate the combined effects of 5-FU and B-escin on apoptosis, colony formation, Bcl-2 signaling ... | Centre of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences, North-West University, South Africa and the National Research Foundation of South-Africa (Grant # - CPRR13091742482). |
Two full-scale passive Earth Entry Vehicles (EEV) with realistic structure, surrogate sample container, and surrogate Thermal Protection System (TPS) were built at NASA Langley Research Center (LaRC) and tested at the Utah Test and Training Range (UTTR). The main test objective was to demonstrate structural integrity a... | The STARDUST Discovery mission will collect samples of cometary coma and interstellar dust and return them to Earth. Five years after launch in February 1999, coma dust will be captured by impact into ultra-low-density silica aerogel during a 6 km/s flyby of Comet Wild 2. The returned samples will be investigated at la... |
The classic presentation of cystic hepatobiliary lesions is usually nonspecific and often identified incidentally. Here we describe the case of a patient presenting with acute pancreatitis resulting from a large centrally located biliary cystadenoma compressing the pancreas. Determination of the origin of the cystic le... | The case is described of a 63-year-old female with a multilocular liver cyst diagnosed as cystadenoma after imaging and fine needle aspiration. The lesion, however, proved to be an invasive cystadenocarcinoma at surgery. Cystadenoma cannot be differentiated, preoperatively, from cystadenocarcinoma and should always be ... |
Large-eddy simulations of transitional incompressible channel flow on rather coarse grids are performed. The standard approximate deconvolution model (ADM) as well as two modifications are compared to fully resolved direct numerical simulation (DNS) calculations. The results demonstrate that it is well possible to simu... | A well-resolved large eddy simulation (LES) of a large-eddy break-up (LEBU) device in a spatially evolving turbulent boundary layer is performed with, Reynolds number, based on free-stream velocity and momentum-loss thickness, of R e θ ≈ 4300. The implementation of the LEBU is via an immersed boundary method. The LEBU ... |
Dental pulp stem cells (DPSCs) are a type of mesenchymal stem cells (MSCs) characterised by self-renewal and multi-lineage differentiation, including chondrocytes, adipocytes, neural cells and osteoblasts, which make it an attractive choice for tissue engineering purposes. Tumour necrosis factor α (TNF-α) had the posit... | BackgroundChronic periodontal disease is an infectious disease consisting of prolonged inflammation of the supporting tooth tissue and resulting in bone loss. Guided bone regeneration procedures have become common and safe treatments in dentistry, and in this context dental stem cells would represent the ideal solution... |
Abstract Genetic variation at 6 nuclear microsatellite loci with biparental inheritance and the maternally inherited mitochondrial DNA (mtDNA) was studied at 3 geographic scales (rookeries, regions, and stocks) in Steller sea lions (Eumetopias jubatus). Genetic variation was high in both nuclear and mtDNA markers as re... | Mitochondrial DNA (mtDNA) control-region sequences and microsatellite loci length polymorphisms were used to estimate phylogeographical patterns (historical patterns underlying contemporary distribution), intraspecific population structure and gender-biased dispersal of Phocoenoides dalli dalli across its entire range.... |
Abstract The synthesis of a series of high temperature triaryl amino chromophores with unprecedented hyperpolarizability values for potential EO applications is described. 4-( N , N -di- p -anisylamino)phenyl donors are for the first time bridged to powerful acceptors such as tricyanovinyldihydrofuran via vinyl thiophe... | The structure, reactivity, natural bond orbital (NBO), linear and nonlinear optical (NLO) properties of three thiazole azo dyes (A, B and C) were monitored by applying B3LYP, CAM-B3LYP and ωB97XD functionals with 6-311++G** and aug-cc-pvdz basis sets. The geometrical parameters,dipolemoments,HOMO-LUMO(highest occupied ... |
BACKGROUND ::: Persistent left superior vena cava (PLSVC) is the most common thoracic venous anomaly. ::: ::: ::: HYPOTHESIS ::: This study examines the epidemiologic, clinical, and morphologic characteristics of a cohort of patients with PLSVC draining into the coronary sinus. ::: ::: ::: METHODS ::: We examined the c... | Congenital anomalies of the thoracic veins are rare yet important developmental abnormalities, usually classified into systemic and pulmonary. They may be encountered incidentally; as such the radiologist must be aware of their imaging presentation and clinical relevance. Furthermore, to understand these anomalies, kno... |
Structural controllability is the generalization of traditional controllability for dynamical systems. During the last decade, interesting biological discoveries have been inferred by applied structural controllability analysis to biological networks. However, false positive/negative information (i.e. nodes and edges) ... | One version of the concept of structural controllability defined for single-input systems by Lin and subsequently generalized to multi-input systems by others, states that a parameterized matrix pair $(A, B)$ whose nonzero entries are distinct parameters, is structurally controllable if values can be assigned to the pa... |
The purpose of the present study was to assess the bond strength of composite resin repairs subjected to different surface treatments and accelerated artificial aging. 192 cylindrical samples (CSs) were prepared and divided into 24 groups (n = 8). Half of the CSs were stored in water for 24 h, and the other half were s... | INTRODUCTION: The shear bond strength of orthodontic brackets bonded to micro-hybrid and micro-particulate resins under different surface treatment methods was assessed. METHODS: Two hundred and eighty test samples were divided into 28 groups (n = 10), where 140 specimens were filled with Durafill micro-particulate res... |
Bevacizumab improves survival when added to chemotherapy in metastatic colorectal cancer (mCRC). We assessed the safety and efficacy of bevacizumab in mCRC patients ≥70 years old (YO) vs. those <70 YO. mCRC patients treated from 2005–2012 who received chemotherapy (physician’s choice) plus bevacizumab were included. Th... | PurposeMost metastatic colorectal cancer (mCRC) patients are elderly. This systematic review identifies and describes observational studies evaluating the influence of age on first-line treatment effectiveness in real-world practice.MethodsMedline and EMBASE were searched up to May 2016. The included studies were those... |
Abstract The corrosion protection properties of polypyrrole (PPy) electrodeposited onto aluminium alloy 2024-T3 substrates were investigated as a function of the doping agent. We used camphor sulfonic acid (CSA), para toluene sulfonic acid (p-TSA), phenylphosphonic acid (PPA), oxalic acid (OA) and cerium nitrate salt (... | Polypyrrole coating doped with dodecylsulfate anions was electrodeposited by cyclic voltammetry and constant current technique on type 304 stainless steel used for bipolar plates of a proton-exchange membrane fuel cell from a basic solution of 0.2M pyrrole monomer solution containing dodecylsulfate sodium as supporting... |
Abstract: This chapter provides an up-to-date account of reuse, recycling and devulcanization of natural and synthetic isoprene rubbers. Landfilling and waste utilization, grinding and pulverization, high pressure high temperature sintering, pyrolysis, microwave, ultrasonic, chemical, mechanochemical and biochemical de... | In general, composite materials are difficult to recycle. Tires belong to this class of materials. On top, one of their main constitutents, vulcanized rubber, is as elastomer, which cannot be remolten and hence is particularly challenging to put to a new use. Today, the main end-of-life routes of tires and other rubber... |
We report on measurements of the surface quality (shape) of aluminium compound refractive lenses using a thin collimated X-ray beam from one of our bending magnet diagnostics beam ports. Two types of lenses were tested for overall radius of curvature, surface quality and thickness: commercially available lenses (RWTH A... | Multiple refractive lenses with a focal length of 1 to 2 m are a new tool for focusing hard x rays to a spot size in the micrometer range. They may be used for microdiffraction, microfluorescence, and coherent imaging. The lenses may be focusing in one or two dimensions. In this article, we have calculated the transmis... |
We analyze carrier-envelope phase (CEP) effects on electron wave-packet momentum and energy spectra produced by one or two few-cycle attosecond xuv pulses. The few-cycle attosecond pulses are assumed to have arbitrary phases. We predict CEP effects on ionized electron wave-packet momentum distributions produced by atto... | Ultrafast electronic dynamics are typically studied using pulsed lasers. We demonstrate a complementary experimental approach: quantum simulation of ultrafast dynamics using trapped ultracold atoms. Counter-intuitively, this technique emulates some of the fastest processes in atomic physics with some of the slowest, le... |
OBJECTIVE ::: To investigate the antiinflammatory activities of aqueous extract of Occimum gratissmium (OGE) with emphasis on expression of proinflammatory cytokines in Lipopolysaccharide (LPS)-stimulated epithelial cell BEAS-2B. ::: ::: ::: METHODS ::: Effects of OGE on cell viability were determined by MTT assay. mRN... | BACKGROUND ::: We have shown that serine proteases in German cockroach extract increase TNF-alpha-induced expression of IL-8 in human bronchial epithelial cells. The mechanism by which cockroach proteases regulate cytokine expression is unknown; however, protease-activated receptors (PARs) might play a role. ::: ::: ::... |
A large temperature range of stress-induced martensitic transformation with >8% superelastic strain is demonstrated in [1 0 0]-oriented Co49Ni21Ga30 single crystals. The nature of the superelastic response is greatly affected by temperature and test history due to the temperature-dependent dominant microstructural mech... | Conventional shape memory alloys (SMAs), such as binary Ni–Ti, are typically limited to service temperatures below 100 °C. Recent studies on Co–Ni–Ga high-temperature SMAs revealed the potential that these alloys can be used up to temperatures of about 400 °C. Analysis of the cyclic functional properties showed that de... |
Abstract This paper presents a simple method to measure Young’s moduli of thin films shaped into micro-cantilever beams (MCBs). Young’s moduli of electroplated Ni/Fe thin films and 〈1 1 0〉-oriented silicon have been determined in this paper based on this method. First, the principle of the balance method is introduced ... | Normally closed microcages based on highly compressively stressed diamond-like carbon (DLC) and electroplated Ni bimorph structures have been simulated, fabricated and characterized. Finite-element and analytical models were used to simulate the device performance. It was found that the radius of curvature of the bimor... |
Abstract Values of Δ G s o (298.15 K) (gas→liquid), excess free energy G E (298.15 K) and corresponding enthalpies and entropies of solution of 15 homologous series of polar and non-polar solutes in n -hexadecane are predicted using a theoretical method based on the Hildebrand–Scatchard solubility parameter. The values... | A robust and efficient procedure is presented for calculating the solubility parameter. An analytical equation for internal pressure is proposed. Through a simple relation reported by Verdier and Andersen (fluid phase equilibrium 231: 125–137, 2005), one can easily find the solubility parameter via our analytical equat... |
This study sets out to investigate the distortion angle, microstructure, and hardness of St 37 steel plate weld joint produced by FCAW using the welding current of 80, 110, and 140 A. By using flat position, CO 2 and E71T-1 wire were utilized as a shielding gas and electrode filler, respectively. The distortion angle m... | The influence of flux cored arc welding (FCAW) process parameters such as welding current, travel speed, voltage and CO2 shielding gas flow rate on bowing distortion of 409M ferritic stainless steel sheets of 2 mm in thickness was discussed. The bowing distortions of the welded plates were measured using a simple devic... |
How do buildings contribute to an organization’s sense of what it is? In this article, we present the findings of a major archival study of an iconic university building to answer this question. Founded in the 19th century as a college for women, the building is analysed as a gendered space that embodies meanings that ... | The purpose of this paper is to present the role of reflexivity in relation to archives and narratives.,The authors problematize the concept of “archive,” by engaging with debates in philosophy and the archival theory. The authors also revisit historical theories and debates on the role of the narrative within historio... |
Jellium correction on the fissionability parameter is estimated within a Liquid Drop Model of the charged metallic cluster. This correction modifies the critical condition of fission and, it becomes relevant for small multicharged clusters. | Mechanical molecular models thermodynamics the theory of Van Der Waals statistical mechanics of the liquid-gas surface model fluids in the mean-field approximation computer simulation of the liquid-gas surface calculation of the density profile three-phase equilibrium interfaces near critical points. Appendices: thermo... |
This essay was prompted by and is a response to Yiannakis’ (1989) article in which he called for a more applied orientation on the part of sociologists of sport. In our response, we argue that Yiannakis’ position is flawed because he fails to explore the oftentimes political overdetermination of academic process and th... | This paper presents a historical sociological analysis of the sociology of sport. It draws on theoretical insights from the sociology of professions to examine ‘state-of-the-field’ reviews written by sociologists of sport. The paper argues that in establishing why the sociology of sport emerged, how people identified i... |
Responses to demand uncertainty in the field of health-care services is a very timely research issue because of ongoing changes in demand patterns that are driven by demographics and recent changes in the delivery of these services. Despite its importance to researchers, the literature on demand management, capacity ma... | Motivation for this Research: ::: It is necessary to manage health care capacity effectively and efficiently, as it is in the interest of patients, medical practitioners, and health care management. An accurate assessment of capacity management performance is necessary for the improvement of capacity management. Curren... |
Using a monoclonal antibody to the human epidermal growth factor (EGF) receptor (EGF-R1), we have followed the metabolism of the receptor and the pathway of its internalization in KB cells after the addition of EGF. Measurement of surface binding of 125I-labeled EGF showed that about 80% of EGF binding activity disappe... | Binding of the peptide growth factors (GF) on their surface receptors triggers rapid endocytosis of ligand-receptor complexes via clathrin-coated pits. Internalized receptors pass through the endosomal compartment where they are efficiently sorted to the lysosomal degradation pathway. Accelerated internalization and de... |
Current graphical techniques for design of water networks based on pinch analysis typically separate targeting from network design stage. In addition, most graphical allocation and network design tools that use the cleanest source to satisfy the cleanest demand fail when the flow rate of a demand is met but the mass lo... | Nowadays, water demands are growing every year because most process industries and buildings use water for a wide range of applications. In order to reduce water demand, industries have come out with a better water management and water minimisation technique. Water pinch analysis (WPA) is a systematic technique for the... |
SUMMARY Contested rules between the state and local communities over use and protection of forest affect environmental services and livelihood options in Indonesia's forest margins. Success in forest protection and emission reduction (REDD) requires conflict resolution. The recent village forest (Hutan Desa) regulation... | The objective of REDD payment distribution mechanisms is to support policies and measures that reduce deforestation and degradation through transfer of revenues from international REDD funds or carbon markets to (or within) national levels. This may provide benefits of three types: a) shared responsibility for reducing... |
Subduction-zone metamorphism is considered to be a major chemical filter for both the arc magmatism and mantle compositional heterogeneity. To understand the element transport during this process, we conducted a petrographic and geochemical study of the bulk-rock blueschists and eclogites from the western Tianshan ultr... | The composition of continental subduction-zone fluids varies dramatically from dilute aqueous solutions at subsolidus conditions to hydrous silicate melts at supersolidus conditions, with variable concentrations of fluid-mobile incompatible trace elements. At ultrahigh-pressure (UHP) metamorphic conditions, supercritic... |
Intense research efforts have contributed to feature extraction based on the discriminant information about class mean. Comparatively, the discriminant information about class covariance for the multiclass problem is not fully explored. In this study, we focus our efforts on this type of discriminant information about ... | Abstract This paper proposes a new discriminant analysis with orthonormal coordinate axes of the feature space. In general, the number of coordinate axes of the feature space in the traditional discriminant analysis depends on the number of pattern classes. Therefore, the discriminatory capability of the feature space ... |
The thermodynamically stable Form II of the antidiabetic drug tolbutamide exhibits a thin fiber needle shape which renders it intractable for isolation and downstream processing. This work implements two in situ process analytical technology (PAT) methods, namely, attenuated total reflectance-Fourier transform infrared... | A semi-continuous crystallizer is demonstrated that combines optimally controlled dual-impinging jet mixers with a feedback-controlled stirred tank to achieve a very high degree of control of the crystal size distribution. The design is based on continuous seeding and physical separation and optimization of crystal nuc... |
We discuss existence and uniqueness of stationary and ergodic nonlinear autoregressive processes when exogenous regressors are incorporated in the dynamic. To this end, we consider the convergence of the backward iterations of dependent random maps. In particular, we give a new result when the classical condition of co... | This reference work and graduate level textbook considers a wide range of models and methods for analyzing and forecasting multiple time series. The models covered include vector autoregressive, cointegrated, vector autoregressive moving average, multivariate ARCH and periodic processes as well as dynamic simultaneous ... |
Field prediction is an essential component of the planning process of cellular radio systems. This task is particularly time- and money-consuming in the urban environment, where cell size is of the order of a few hundred meters, and the influence of the city structure (building size and dimension, street width, orienta... | Wireless technologies, developed within ICT at the end of XX, beginning of XXI century, are followed by adequate analytical support, which also made their implementation faster. At the beginning, their similarity with WiMAX concept launched the implementation of WiMAX systems in the scope of closely related research ac... |
Abstract The very high level of requirements for certification procedures often limit research and development departments to innovate using increments and iterations during the design process for medical devices (MD). Instead of this semi-empirical approach, a structured procedure, a breakthrough innovation should be ... | A 3D finite element model of in vitro intact and implanted mandibles with different temporomandibular joints (TMJ) was analyzed. Three TMJ implant geometries were assessed. The displacements, stress and strain fields on the condyle were obtained for both simulated cases. Strains were also assessed near the screws that ... |
This article describes the evaluation of a teaching pack designed for nursing students to acquire the knowledge required for safe administration of blood transfusions. The Serious Hazards of Transfusion (SHOT) Committee is a confidential reporting body, which gathers data from the United Kingdom and reports the serious... | The Scottish National Blood Transfusion service have developed an educational programme aimed at ensuring a high standard of care for blood transfusions to minimise risk to patients and healthcare practitioners. This paper investigates whether knowledge and understanding of, and attitudes towards, safe practice decline... |
The purpose of the WHO-sponsored International Collaborative Study of Oral Health Outcomes (ICS-II) was to provide policy-makers and researchers with detailed, reliable, and valid data on the oral health situation in their countries or regions, together with comparative data from other dental care delivery systems. ICS... | Objective : The aim was to assess the relationship between the variability of data, sample size (n) and costs involved in epidemiologic surveys of dental caries. Research design and settings : In order to conduct this study, simulations of the variation in costs of hypothetic epidemiologic surveys were made and studied... |
Rodent models are increasingly important in translational neuroimaging research. In rodent neuroimaging, particularly magnetic resonance imaging (MRI) studies, brain extraction is a critical data preprocessing component. Current brain extraction methods for rodent MRI usually require manual adjustment of input paramete... | Magentic Reasonance Imaging for mouse phenotype study is one of the important tools to understand human ::: diseases. In this paper, we present a fully automatic pipeline for the process of morphometric mouse brain ::: analysis. The method is based on atlas-based tissue and regional segmentation, which was originally d... |
Y.-C.C. and A.-Y.L. contributed equally to this work. V.T. gratefully acknowledges the research award from the Doctoral New Investigator Award from ACS Petroleum Fund (ACS PRF 54717-DNI10, V.T.). Characterization and fabrication of HER electrodes in this work were performed as User Proposals (#4240) at the Molecular Fo... | Abstract MoS 2 quantum dots (QDs) are loaded onto TiO 2 nanotube arrays (NTAs) via a facile strategy of combining electrochemical exfoliation with electrophoretic deposition (EFED). The optimal MoS 2 @TiO 2 NTAs exhibits a low onset potential (76 mV vs RHE) with the Tafel slope of 93 mV dec −1 . The reported synthesis ... |
Nowadays plant monitoring and control of renewable energy sources can take advantage of the use of unmanned aerial technologies. This manuscript aims to develop an image post-processing tool for remote aerial images able to help operation and maintenance operators in photovoltaic (PV) defects detection using light unma... | Photovoltaic (PV) panels are a clean and widespread way to produce renewable energy from sunlight; at the same time, such plants require maintenance, since solar panels can be affected by many types of damaging factors and have a limited yet variable lifespan. With the impressive growth of such PV installations, it is ... |
This paper presented two inter-firm IT governance strategies, namely, balancing and complementing governance strategies.We examined the relationship between two governance strategies and relational performance.We also studied the influence of a contingent factor, IT ambidexterity on this value generation process.Our re... | Although the existing literature has shown that the choice of governance structure plays a key role in inter-organizational performance, the nature of construct measurability still remains equivocal. The diversity of terminologies used means that the full potential of most studies may be lost in the confusion of indist... |
This paper presents a statistical characterization of Ultra-Wideband (UWB) channel for ship cabin environment based on measurements carried out in the frequency-domain and covered the frequency band of 6–9GHz. According to the results of measurement, it is observed that rays arrive in clusters, so we describe the multi... | For frequency selective channels, the delay spread is one measure for the channel distortion. This channel characterization is possible by either a CW frequency sweep, which gives directly the transfer function, or by sounding the channel with pulses which results in the impulse response. When the sounding pulse become... |
In this paper we study variational inequalities using the Schwarz method. The main idea of this method consists in decomposing the domain in two subdomains. We give a simple proof for the main result concerning error estimates in uniform norm, using S. Zhou [14] geometrical convergence and Courtey-Dumont [6] uniform co... | In this paper, we provide a maximum norm analysis of a finite difference scheme defined on overlapping nonmatching grids for second order elliptic equations. We consider a domain which is the union of p overlapping subdomains where each subdomain has its own independently generated grid. The grid points on the subdomai... |
Abstract Background β-Blockers have been shown to reduce both morbidity and mortality rates in patients with acute coronary syndromes. However, because of potential side effects, their use is limited in patients who might benefit the most from such therapy. It was thought that the use of an ultra-short-acting intraveno... | The coexistence of coronary artery disease (CAD) and chronic obstructive pulmonary disease (COPD) is frequent because of common etiological factors. Β-Blockers remain underutilized in patients with CAD who also have COPD. This study was performed to evaluate the safety of Β-1 selective blocker agents in CAD patients wi... |
This paper reports and analyses 20 keratoplasties with or without anterior segment reconstruction carried out for penetrating injuries of the anterior segment. The results show that 80% clear grafts were achieved and 65% of eyes had vision restored to 6/18 or better. No eyes were lost. The complications were retinal de... | BACKGROUND ::: To evaluate the results of penetrating keratoplasty (PK) due to trauma-related corneal scarring. ::: ::: ::: METHODS ::: We evaluated 24 eyes of 24 patients who underwent PK due to trauma-related scarring of the cornea between May 2010 and June 2016. The postoperative visual acuity, graft transparency, a... |
We show that every language in NP has a probabilistically checkable proof of proximity (i.e., proofs asserting that an instance is "close" to a member of the language), where the verifier's running time is polylogarithmic in the input size and the length of the probabilistically checkable proof is only polylogarithmica... | During an adaptive k-out-of-N oblivious transfer (OT), a sender has N private documents, and a receiver wants to adaptively fetch k documents from them such that the sender learns nothing about the receiver’s selection and the receiver learns nothing more than those chosen documents. Many fully simulatable and universa... |
Resveratrol and its derivatives have been shown to display beneficial effects to neurodegenerative diseases. However, the molecular mechanism of resveratrol and its derivatives on prion conformational conversion is poorly understood. In this work, the interaction mechanism between prion and resveratrol as well as its d... | Trans-resveratrol, the most well-known polyphenolic stilbenoid, is found in grapes and accordingly in wine and it is considered to be beneficial for human health, especially towards the aging-linked cell alterations by providing numerous biological activities, such as anti-oxidant, antitumoral, antiviral, anti-inflamma... |
Primary or isolated chylopericardium of unknown etiology is considered a rare cause of pericardial effusion. Its etiology is obscure but certain communication between the lymphatic system and pericardial sac was suggested. Up to 1991, there was only one case report that successfully showed the direct communication by a... | Primary chylopericardium is an extremely rare disease. This report presents two cases of this disease, in a 47-year-old man and 21-year-old woman. Both cases were given diagnosis of primary chylopericardium by chylous pericardial fluid examination and lymphangio-scintigraphy which demonstrated abnormal communication be... |
With aging of the HIV-infected population, non-AIDS conditions such as cardiovascular disease (CVD) now account for substantial mortality and morbidity. While myocardial infarction is the major outcome of interest in the field of HIV and CVD, cerebrovascular disease remains understudied, especially in the Southeastern ... | This study examined whether global HIV-associated neurocognitive impairment (NCI), assessed with the HIV-Dementia Scale (HDS), predicted mortality in an ethnically diverse sample of 209 HIV-positive adults. Participants were predominantly in the mid-range of illness at baseline, and followed over 13-years. At baseline,... |
Conditions are formulated under which a representation of an intrinsic C*‐ algebra of (often quasilocal) observables of an infinite system is appropriate to describe measurement‐type processes: such a representation should allow for the description of robust experiments, it should be separable, and the pointer observab... | Spontaneous symmetry breaking (SSB) in quantum systems, such as ferromagnets, is normally described as (or as arising from) degeneracy of the ground state; however, it is well established that this degeneracy only occurs in spatially infinite systems, and even better established that ferromagnets are not spatially infi... |
We present a new general parameterization for aqueous solvation free energies of molecules and ions in aqueous solution. It is obtained by extending a semianalytic treatment of solvation recently proposed for use with molecular mechanics and liquid simulations by Still et al. As extended here, the solvation terms are i... | Quantitative structure−property relationships (QSPR) of critical temperatures with small numbers of physically significant molecular descriptors are developed using the CODESSA (comprehensive descriptors for structural and statistical analysis) technique. A highly significant one-parameter model correlates to the criti... |
We show how the rheological response of a material to applied loads can be systematically coded, analyzed and succinctly summarized, according to an individual grain’s property (e.g. kinematics). Individual grains are considered as their own smart sensor akin to microelectromechanical systems (e.g. gyroscopes, accelero... | Granular materials (e.g, geological materials, powders and grains) when subjected to shear or compression deform through grain rearrangements. The structural topology of the grains, or fabric, can be usefully represented as a complex (contact) network whereby network nodes correspond to individual grains and network li... |
To examine the in vivo contribution of L-selectin in the sensitization of tumor-specific CTL, we investigated the effects of treatment with the anti-L-selectin monoclonal antibody (MAb) MEL-14 on the immune response to Moloney-murine sarcoma virus (M-MSV)-induced tumors, which exhibit spontaneous regression following g... | INTRODUCTION ::: We have performed TNF-alpha gene transfection in a mouse mammary cancer line and found significant antitumor effects. We hypothesize that the antitumor effects observed in this model are mediated by ICAM-1 and by the recruitment of CD4+ and CD8+ T cells. In vivo (Balb/c mice) tumor growth inhibition, t... |
By quantizing the generalized Drinfeld-Sokolov reduction scheme for arbitrarysl2 embeddings we show that a large set ::: Open image in new window ::: of quantumW algebras can be viewed as (BRST) cohomologies of affine Lie algebras. The set ::: Open image in new window ::: contains many knownW algebras such asW N andW 3... | In a preferred embodiment of the invention, a plurality of spherical float elements mounted on levers which levers are each mounted for reciprocation along elongated axes thereof substantially vertically thereof to the sea bottom, with interconnected drive shafts for mutually contributing to a common drive, the plurali... |
A full-length cDNA coding for a putative intestinal carboxylesterase (iCE) was isolated from a human small intestine cDNA library. The cDNA has an open reading frame of 559 amino acids with up to 65% homology to other carboxylesterases of different mammalian species. The deduced amino-acid sequence contains many struct... | Purpose: The oral prodrug of gemcitabine LY2334737 is cleaved systemically to gemcitabine; the mechanism responsible for hydrolysis is unknown. LY2334737 cytotoxicity was tested in the NCI-60 panel; mining of microarray expression data identified carboxylesterase (CES) as a top hydrolase candidate. Studies examined whe... |
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