owaiskha9654/Multi-Label-Classification-of-PubMed-Articles
Text Classification • 0.1B • Updated • 24 • 15
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Tasks:
Text Classification
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csv
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multi-label-classification
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English
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10K - 100K
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Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Expression of p53 and coexistence of HPV in premalignant lesions and in cervical cancer. | Fifty-four paraffin embedded tissue sections from patients with dysplasia (21 cases) and with cervical cancer (33 cases) were analysed. HPV was detected and identified in two stages. Firstly, using mixed starters, chosen genomic DNA sequences were amplified; secondly the material thus obtained was analyzed by hybridiza... | ['DNA Probes, HPV', 'DNA, Viral', 'Female', 'Humans', 'Immunohistochemistry', 'Papillomaviridae', 'Tumor Suppressor Protein p53', 'Uterine Cervical Dysplasia', 'Uterine Cervical Neoplasms'] | 8,549,602 | [['D13.444.600.223.555', 'D27.505.259.750.600.223.620', 'D27.720.470.530.600.223.620'], ['D13.444.308.568'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344.51... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Vitamin D status in pregnant Indian women across trimesters and different seasons and its correlation with neonatal serum 25-hydroxyvitamin D levels. | The present cross-sectional study was conducted to determine the vitamin D status of pregnant Indian women and their breast-fed infants. Subjects were recruited from the Department of Obstetrics, Armed Forces Clinic and Army Hospital (Research and Referral), Delhi. A total of 541 apparently healthy women with uncomplic... | ['Adult', 'Alkaline Phosphatase', 'Breast Feeding', 'Cross-Sectional Studies', 'Female', 'Humans', 'India', 'Infant', 'Infant Nutrition Disorders', 'Lactation', 'Mothers', 'Nutritional Status', 'Parathyroid Hormone', 'Pregnancy', 'Pregnancy Complications', 'Pregnancy Trimesters', 'Seasons', 'Vitamin D', 'Vitamin D Defi... | 21,736,816 | [['M01.060.116'], ['D08.811.277.352.650.035'], ['F01.145.407.199', 'G07.203.650.195', 'G07.203.650.220.500.500', 'G07.203.650.353.199'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.245.393'], ['M01.060.703'], ['C18.654.422'], ... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]',... | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
[Identification of a functionally important dipeptide in sequences of atypical opioid peptides]. | The occurrence of individual amino acids and dipeptide fragments in the sequences of 60 known atypical opioid peptides was analyzed. An expressed predominance of Tyr-Pro fragment suggested a high probability of analgesic activity for this dipeptide, and it was experimentally studied. It was shown on somatic and viscera... | ['Amino Acid Sequence', 'Analgesics, Opioid', 'Animals', 'Consensus Sequence', 'Dipeptides', 'Guinea Pigs', 'In Vitro Techniques', 'Male', 'Mice', 'Molecular Sequence Data', 'Muscle Contraction', 'Muscle, Smooth', 'Narcotic Antagonists', 'Opioid Peptides', 'Pain Measurement', 'Rats', 'Receptor, Cannabinoid, CB1', 'Rece... | 19,060,934 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D27.505.696.277.600.500', 'D27.505.696.663.850.014.760.500', 'D27.505.954.427.040.550.500', 'D27.505.954.427.210.600.500'], ['B01.050'], ['G02.111.570.580.175'], ['D12.644.456.345'], ['B01.050.150.900.649.313.992.550'], ['E05.481'], ['B01.050.150.900.649.313.992.635.505.50... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Multilayer capsules: a promising microencapsulation system for transplantation of pancreatic islets. | In 1980, Lim and Sun introduced a microcapsule coated with an alginate/polylysine complex for encapsulation of pancreatic islets. Characteristic to this type of capsule is, that it consists of a plain membrane which is formed during a single procedural step. With such a simple process it is difficult to obtain instantl... | ['Acrylic Resins', 'Alginates', 'Animals', 'Biocompatible Materials', 'Biopolymers', 'Carboxymethylcellulose Sodium', 'Cells, Cultured', 'Compressive Strength', 'Drug Compounding', 'Female', 'Fibrosis', 'Glucuronic Acid', 'Hexuronic Acids', 'Islets of Langerhans Transplantation', 'Materials Testing', 'Microspheres', 'M... | 11,426,874 | [['D05.750.716.822.111', 'D25.720.716.822.111', 'J01.637.051.720.716.822.111'], ['D09.698.068'], ['B01.050'], ['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['D05.750.078', 'D25.720.099', 'J01.637.051.720.099'], ['D09.698.365.180.663.329'], ['A11.251'], ['G01.374.180'], ['E05.916.270'], ['C23.550.355'], ['D02.241.0... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Nanohydrogel with N,N'-bis(acryloyl)cystine crosslinker for high drug loading. | Substantially improved hydrogel particles based on poly(N-isopropylacrylamide) (pNIPA) have been obtained. First, as a result of replacing commercially available N,N'-bis(acryloyl)cystamine (BAC), the crosslinker, with acryloyl derivative of cystine containing a carboxylic group (BISS), the hydrogel particles acquired ... | ['Antineoplastic Agents', 'Cell Proliferation', 'Cell Survival', 'Cross-Linking Reagents', 'Cystine', 'Doxorubicin', 'Drug Carriers', 'Drug Liberation', 'HeLa Cells', 'Humans', 'Hydrogels', 'Nanoparticles'] | 28,323,099 | [['D27.505.954.248'], ['G04.161.750', 'G07.345.249.410.750'], ['G04.346'], ['D27.720.470.410.210'], ['D01.248.497.158.874.390.369', 'D01.875.350.850.150.369', 'D02.886.030.230.369', 'D02.886.520.150.087', 'D12.125.095.369', 'D12.125.119.369', 'D12.125.166.230.369'], ['D02.455.426.559.847.562.050.200.175', 'D04.615.562.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
A new <i>Panolis</i> H?bner, [1821] species from Vietnam (Lepidoptera, Noctuidae, Orthosiini). | Panolis is a well-defined and compact Palearctic trifine Noctuidae genus within the subfamily Hadeninae, tribus Orthosiini. It is currently represented by seven species and one subspecies: Panolis flammea ([Denis & Schifferm?ller], 1775), Panolis japonica Draudt, 1935, Panolis variegatoides Poole, 1989, Panolis exquisi... | ['Animal Distribution', 'Animals', 'Asia', 'Larva', 'Moths', 'Vietnam'] | 28,609,947 | [['F01.145.113.069', 'G16.049'], ['B01.050'], ['Z01.252'], ['B05.500.500', 'G07.345.500.550.500.500'], ['B01.050.500.131.617.720.500.500.937.650'], ['Z01.252.145.945']] | ['Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Characterization of neutron field in a NPP workplace. | At the Krsko Nuclear Power Plant (NPP), albedo dosimeters are used for personal neutron dosimetry. Spectrometric measurements allow determination of reference dosimetric values of realistic neutron fields to be used for calibration of albedo dosimeters. The Laboratory for Neutron Metrology and Dosimetry from the Instit... | ['Algorithms', 'Equipment Design', 'Equipment Failure Analysis', 'France', 'Internationality', 'Occupational Exposure', 'Power Plants', 'Radiation Dosage', 'Radiation Monitoring', 'Radiation Protection', 'Reproducibility of Results', 'Sensitivity and Specificity'] | 17,416,593 | [['G17.035', 'L01.224.050'], ['E05.320'], ['E05.325.192'], ['Z01.542.286'], ['I01.615'], ['N06.850.460.350.600'], ['J01.780', 'J03.540.680'], ['E05.799.513', 'G01.750.740', 'N06.850.810.250'], ['E05.799.638', 'N06.850.780.375.700', 'N06.850.810.370'], ['N06.850.810.425'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 |
Tramadol vs dexmedetomidine for emergence agitation control in pediatric patients undergoing adenotonsillectomy with sevoflurane anesthesia: prospective randomized controlled clinical study. | BACKGROUND: This study was designed to compare the efficacy of an intraoperative single dose administration of tramadol and dexmedetomidine on hemodynamics and postoperative recovery profile including pain, sedation, emerge reactions in pediatric patients undergoing adenotonsillectomy with sevoflurane anesthesia.METHOD... | ['Adenoidectomy', 'Airway Extubation', 'Analgesics, Non-Narcotic', 'Analgesics, Opioid', 'Anesthetics, Inhalation', 'Bradycardia', 'Child', 'Child, Preschool', 'Dexmedetomidine', 'Emergence Delirium', 'Female', 'Humans', 'Hypotension', 'Male', 'Methyl Ethers', 'Pain Measurement', 'Pain, Postoperative', 'Prospective Stu... | 28,283,018 | [['E04.580.068'], ['E02.041.249', 'E05.008'], ['D27.505.696.663.850.014.040', 'D27.505.954.427.040.100'], ['D27.505.696.277.600.500', 'D27.505.696.663.850.014.760.500', 'D27.505.954.427.040.550.500', 'D27.505.954.427.210.600.500'], ['D27.505.696.277.100.035.060', 'D27.505.954.427.210.100.035.060'], ['C14.280.067.319', ... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Nucleotide diphosphates activate the ATP-sensitive potassium channel in mouse skeletal muscle. | Patch-clamp techniques were used to study the effects of internal nucleotide diphosphates on the KATP channel in mouse skeletal muscle. In inside-out patches, application of GDP (100 microM) and ADP (100 microM) reversibly increased the channel activity. In the presence of internal Mg2+ (1 mM), low concentrations of AD... | ['Adenosine Diphosphate', 'Adenosine Triphosphate', 'Animals', 'Electrophysiology', 'Guanosine Diphosphate', 'Magnesium', 'Mice', 'Muscles', 'Potassium Channels', 'Thionucleotides'] | 1,488,275 | [['D03.633.100.759.646.138.124', 'D13.695.667.138.124', 'D13.695.827.068.124'], ['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['B01.050'], ['H01.158.344.528', 'H01.158.782.236'], ['D03.633.100.759.646.454.340', 'D13.695.667.454.340', 'D13.695.827.426.340'], ['D01.268.552.437', 'D01.268.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Using Standardized Checklists Increase the Completion Rate of Critical Actions in an Evacuation from the Operating Room: A Randomized Controlled Simulation Study. | INTRODUCTION: Hospital evacuations of patients with special needs are extremely challenging, and it is difficult to train hospital workers for this rare event.Hypothesis/Problem:Researchers developed an in-situ simulation study investigating the effect of standardized checklists on the evacuation of a patient under gen... | ['Checklist', 'Civil Defense', 'Emergencies', 'Female', 'Humans', 'Male', 'Natural Disasters', 'Operating Rooms', 'Patient Care Team', 'Patient Safety', 'Simulation Training', 'Time Factors', 'United States'] | 31,389,323 | [['N05.715.360.300.179'], ['I01.451.227'], ['C23.550.291.781', 'N06.230.100.083', 'N06.850.376'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N06.230.100.230'], ['N02.278.388.700'], ['N04.590.715'], ['N06.850.135.060.075.399'], ['I02.903.847'], ['G01.910.857'], ['Z01.107.567.875']] | ['Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Tolerability of the low-affinity, use-dependent NMDA antagonist AR-R15896AR in stroke patients: a dose-ranging study. | BACKGROUND AND PURPOSE: AR-R15896AR is a use-dependent, low-affinity blocker of the NMDA ion channel with neuroprotective effects in animal models of focal cerebral ischemia. This study aimed to establish the highest safe and tolerated loading and maintenance dosing regimen of AR-R15896AR in acute ischemic stroke patie... | ['Aged', 'Dose-Response Relationship, Drug', 'Double-Blind Method', 'Drug Evaluation', 'Excitatory Amino Acid Antagonists', 'Female', 'Humans', 'Infusions, Intravenous', 'Male', 'Pyridines', 'Receptors, N-Methyl-D-Aspartate', 'Severity of Illness Index', 'Stroke', 'Survival Rate', 'Treatment Outcome'] | 11,157,184 | [['M01.060.116.100'], ['G07.690.773.875', 'G07.690.936.500'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['E05.290.625', 'E05.337.425'], ['D27.505.519.625.190.300', 'D27.505.696.577.190.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.082.500', 'E02.319.26... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Spatial distribution of external and internal intercostal activity in dogs. | 1. The observation that the external and internal interosseous intercostal muscles in the dog show marked regional differences in mechanical advantage has prompted us to re-examine the topographic distribution of electrical activity among these muscles during spontaneous breathing. 2. Inspiratory activity was recorded ... | ['Animals', 'Apnea', 'Dogs', 'Electric Stimulation', 'Electromyography', 'Electrophysiology', 'Hypercapnia', 'Intercostal Muscles', 'Pressure', 'Respiration, Artificial', 'Respiratory Mechanics'] | 10,373,710 | [['B01.050'], ['C08.618.085', 'C23.888.852.130'], ['B01.050.150.900.649.313.750.250.216.200'], ['E05.723.402'], ['E01.370.405.255', 'E01.370.530.255'], ['H01.158.344.528', 'H01.158.782.236'], ['C23.888.852.544'], ['A02.633.567.900.500'], ['G01.374.715'], ['E02.041.625', 'E02.365.647.729', 'E02.880.820'], ['G09.772.705.... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Dysbiosis of the Gut Microbiome is associated with Tumor Biomarkers in Lung Cancer. | Lung cancer is a malignancy with high morbidity and mortality worldwide. More evidences indicated that gut microbiome plays an important role in the carcinogenesis and progression of cancers by metabolism, inflammation and immune response. However, the study about the characterizations of gut microbiome in lung cancer ... | ['Aged', 'Bacteria', 'Biomarkers, Tumor', 'Dysbiosis', 'Feces', 'Female', 'Gastrointestinal Microbiome', 'Humans', 'Lung Neoplasms', 'Male', 'Middle Aged', 'RNA, Ribosomal, 16S'] | 31,595,156 | [['M01.060.116.100'], ['B03'], ['D23.101.140'], ['C23.550.308'], ['A12.459'], ['G06.591.375', 'G16.500.275.157.049.100.500.375', 'N06.230.124.049.100.500.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['M01.060.116.630'], ['D13.444.735.686.670']] | ['Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Male Urethral Stricture: American Urological Association Guideline. | PURPOSE: The purpose of this Guideline is to provide a clinical framework for the diagnosis and treatment of male urethral stricture.MATERIALS AND METHODS: A systematic review of the literature using the Pubmed, Embase, and Cochrane databases (search dates 1/1/1990 to 12/1/2015) was conducted to identify peer-reviewed ... | ['Endoscopy', 'Follow-Up Studies', 'Humans', 'Male', 'Practice Guidelines as Topic', 'Severity of Illness Index', 'Societies, Medical', 'Treatment Outcome', 'United States', 'Urethral Stricture', 'Urologic Surgical Procedures, Male', 'Urology'] | 27,497,791 | [['E01.370.388.250', 'E04.502.250'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N04.761.700.350.650', 'N05.700.350.650'], ['E05.318.308.980.438.475.456.500', 'N05.715.360.300.800.438.375.364.500', 'N06.850.520.308.980.438... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
Radiobiologic risk estimation from dental radiology. Part I. Absorbed doses to critical organs. | The aim of the present study was to generate one consistent set of data for evaluating and comparing radiobiologic risks from different dental radiographic techniques. To accomplish this goal, absorbed doses were measured in fourteen anatomic sites from (1) five different panoramic machines with the use of rare-earth s... | ['Bone Marrow', 'Cervical Vertebrae', 'Equipment Design', 'Film Dosimetry', 'Humans', 'Mandible', 'Models, Structural', 'Pituitary Gland', 'Radiation Dosage', 'Radiobiology', 'Radiography, Panoramic', 'Risk Factors', 'Salivary Glands', 'Thyroid Gland', 'X-Ray Film', 'X-Ray Intensifying Screens'] | 3,165,508 | [['A15.382.216'], ['A02.835.232.834.151'], ['E05.320'], ['E05.799.638.420', 'N06.850.810.370.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.232.781.324.502.632', 'A14.521.632'], ['J01.897.280.500.545', 'L01.178.820.090.545'], ['A06.300.747', 'A06.688.357.750', 'A08.186.211.180.497.352.435.500', 'A08.... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 |
Massive Chondroblastoma of the Talus: Treatment With En Bloc Talectomy and Tibiocalcaneal Arthrodesis: Long-Term Follow-up of a Case. | Chondroblastomas are benign bone tumors that are usually located at epiphyseal regions of long bones, and are rarely located at the talus. The usual treatment consists of curettage and filling of the bone defect with bone either bone grafts or some other material, such as cement. The authors present a case of a massive... | ['Adult', 'Arthrodesis', 'Bone Cements', 'Bone Neoplasms', 'Bone Transplantation', 'Calcaneus', 'Chondroblastoma', 'Follow-Up Studies', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Radiography', 'Talus', 'Tibia'] | 27,798,068 | [['M01.060.116'], ['E04.555.100'], ['D05.750.716.822.300', 'D25.720.716.822.300', 'D27.720.102.158', 'J01.637.051.720.716.822.300'], ['C04.588.149', 'C05.116.231'], ['E02.095.147.725.052', 'E04.555.130', 'E04.936.580.052'], ['A02.835.232.043.300.710.300'], ['C04.557.450.565.250'], ['E05.318.372.500.750.249', 'N05.715.3... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Anatomy [A]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Alternative pathways of apoptosis induced by methylprednisolone and valinomycin analyzed by flow cytometry. | Apoptosis of murine thymocytes induced by either methylprednisolone or valinomycin was studied by flow cytometry. The apoptosis induced by methylprednisolone followed three stages: an initial decrease in cell volume, indicated by a fall in forward scatter accompanied by faint ethidium bromide staining, a second stage i... | ['Animals', 'Anti-Bacterial Agents', 'Apoptosis', 'Cells, Cultured', 'Cycloheximide', 'DNA Damage', 'Ethers, Cyclic', 'Flow Cytometry', 'Imidazoles', 'In Vitro Techniques', 'Macrolides', 'Male', 'Methylprednisolone', 'Mice', 'Okadaic Acid', 'Thymus Gland', 'Valinomycin'] | 8,375,466 | [['B01.050'], ['D27.505.954.122.085'], ['G04.146.954.035'], ['A11.251'], ['D03.383.621.808.240'], ['G05.200'], ['D02.355.291', 'D04.345.241'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363.342', 'E05.242.386.350'], ['D03.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Methotrexate leukoencephalopathy presenting as Kl?ver-Bucy syndrome and uncinate seizures. | Methotrexate causes several biochemical changes that impact the nervous system. The neurotoxicity usually affects the cerebral white matter, causing a leukoencephalopathy that can be chronic and progressive with cognitive decline. A 15-year-old male developed olfactory seizures and behavioral abnormalities (hypersexual... | ['Adolescent', 'Antimetabolites, Antineoplastic', 'Brain', 'Diagnosis, Differential', 'Enzyme Inhibitors', 'Epilepsies, Partial', 'Humans', 'Kluver-Bucy Syndrome', 'Leukemia', 'Leukoencephalopathy, Progressive Multifocal', 'Male', 'Methotrexate'] | 11,992,760 | [['M01.060.057'], ['D27.505.519.186.144', 'D27.505.954.248.144', 'D27.888.569.042.030'], ['A08.186.211'], ['E01.171'], ['D27.505.519.389'], ['C10.228.140.490.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.380.326', 'F03.615.400.431'], ['C04.557.337'], ['C01.207.245.340.500', 'C01.207.399.750.500'... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Influence of genetic variation in alcohol and aldehyde dehydrogenase on serotonin metabolism. | The influence of genetic variation in alcohol dehydrogenase (ADH; EC 1.1.1.1) and aldehyde dehydrogenase (ALDH; EC 1.2.1.3) on the metabolic pattern of serotonin (5-hydroxytryptamine, 5-HT) in humans was examined from the relative urinary concentrations of the end products 5-hydroxyindole-3-acetic acid (5-HIAA) and 5-h... | ['Alcohol Dehydrogenase', 'Aldehyde Dehydrogenase', 'Asian Continental Ancestry Group', 'Ethanol', 'European Continental Ancestry Group', 'Genetic Variation', 'Genotype', 'Humans', 'Isoenzymes', 'Serotonin'] | 8,035,649 | [['D08.811.682.047.820.250'], ['D08.811.682.657.163.249'], ['M01.686.508.200'], ['D02.033.375'], ['M01.686.508.400'], ['G05.365'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.348', 'D12.776.800.300'], ['D02.092.211.215.801.852', 'D03.633.100.473.914.814', 'D23.469.050.650']] | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Maternal and neonatal red blood cell n-3 polyunsaturated fatty acids inversely associate with infant whole-body fat mass assessed by dual-energy X-ray absorptiometry. | Research regarding polyunsaturated fatty acid (PUFA) status and body composition in neonates is limited. This study tested the relationship between newborn docosahexaenoic acid (DHA) status and body composition. Healthy mothers and their term-born infants (n = 100) were studied within 1 month postpartum for anthropomet... | ['Absorptiometry, Photon', 'Adipose Tissue', 'Adult', 'Body Composition', 'Docosahexaenoic Acids', 'Erythrocytes', 'Fatty Acids, Unsaturated', 'Female', 'Humans', 'Infant, Newborn', 'Male', 'Mothers'] | 31,437,414 | [['E01.370.350.700.024', 'E05.196.712.224.187'], ['A10.165.114'], ['M01.060.116'], ['G02.111.130', 'G03.180', 'G07.100.049'], ['D10.212.302.380.410.210', 'D10.251.355.337.250', 'D10.627.430.450.375'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['D10.251.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Airway complications after lung transplantation: treatment and long-term outcome. | BACKGROUND: Airway complications are a significant cause of morbidity after lung transplantation. Effective treatment reduces the impact of these complications.METHODS: Data from 123 lung (99 single, 24 bilateral) transplants were reviewed. Potential risk factors for airway complications were analyzed. Stenoses were tr... | ['Bronchial Diseases', 'Constriction, Pathologic', 'Female', 'Follow-Up Studies', 'Humans', 'Lung Transplantation', 'Male', 'Middle Aged', 'Risk Factors', 'Stents', 'Time Factors', 'Treatment Outcome'] | 11,269,487 | [['C08.127'], ['C23.300.287'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.928.600.495', 'E04.936.450.495'], ['M01.060.116.630'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N05.715.360.750.625.700.700', 'N06.8... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Postnatal changes in the overall postsynaptic currents evoked in CA1 pyramidal neurons of the rat hippocampus. | Evoked fast postsynaptic currents (fPSCs) during the postnatal development of rats (postnatal day 6-70, P6-P70) were systematically examined in hippocampal CA1 pyramidal neurons using whole-cell recordings with biocytin-filled electrodes. Focal stimulation of the stratum radiatum in the CA1 region elicited fPSCs in 80%... | ['6-Cyano-7-nitroquinoxaline-2,3-dione', 'Anesthetics, Local', 'Animals', 'Animals, Newborn', 'Bicuculline', 'Electrophysiology', 'Evoked Potentials', 'Excitatory Amino Acid Antagonists', 'Excitatory Postsynaptic Potentials', 'Female', 'GABA Antagonists', 'Hippocampus', 'In Vitro Techniques', 'Lidocaine', 'Male', 'Patc... | 12,467,875 | [['D03.633.100.857.160'], ['D27.505.696.277.100.200', 'D27.505.696.663.850.025', 'D27.505.954.427.210.100.200'], ['B01.050'], ['B01.050.050.282'], ['D03.132.098.077', 'D03.633.100.531.085.077'], ['H01.158.344.528', 'H01.158.782.236'], ['G07.265.216.500', 'G11.561.200.500'], ['D27.505.519.625.190.300', 'D27.505.696.577.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
In-situ synthesis of carbon nanotube-graphite electronic devices and their integrations onto surfaces of live plants and insects. | Here we report an unconventional approach for the single-step synthesis of monolithically integrated electronic devices based on multidimensional carbon structures. Integrated arrays of field-effect transistors and sensors composed of carbon nanotube channels and graphitic electrodes and interconnects were formed direc... | ['Animals', 'Biosensing Techniques', 'Environmental Monitoring', 'Gases', 'Graphite', 'Insecta', 'Nanotubes, Carbon', 'Plants'] | 24,742,260 | [['B01.050'], ['E05.601.043'], ['N06.850.460.350.080', 'N06.850.780.375'], ['D01.362'], ['D01.268.150.300', 'D01.578.300'], ['B01.050.500.131.617'], ['D01.268.150.250.500', 'J01.637.512.850.500'], ['B01.650']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Continuous quality improvement, total quality management, and reengineering: one hospital's continuous quality improvement journey. | In recent years, there has been significantly increasing interest in the application of continuous quality improvement (CQI) and total quality management (TQM) in the health care arena. This case analysis is designed to identify and assess the strategies and processes that led to the successful implementation of CQI in... | ['Admitting Department, Hospital', 'Emergency Service, Hospital', 'Humans', 'Inservice Training', 'Institutional Management Teams', 'Management Quality Circles', 'Michigan', 'Organizational Case Studies', 'Organizational Culture', 'Organizational Innovation', 'Patient Admission', 'Process Assessment, Health Care', 'Tot... | 9,735,478 | [['N02.278.216.500.968.040', 'N04.452.442.452.422.040'], ['N02.278.216.500.968.336', 'N02.421.297.195', 'N04.452.442.452.422.336'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I02.574'], ['N04.452.460'], ['N04.452.677.420'], ['Z01.107.567.875.350.500', 'Z01.107.567.875.510.500'], ['N03.349.380.710', 'N05.715.360... | ['Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Isolated adrenocorticotropic hormone deficiency presenting with hypercalcemia in a patient on long-term hemodialysis. | The authors report on a 44-year-old female hemodialysis (HD) patient who presented with hypercalcemia secondary to isolated adrenocorticotropic hormone (ACTH) deficiency. She had been suffering from nausea and abdominal pain caused by recurrent esophageal ulcer. Blood calcium (Ca) adjusted for serum albumin concentrati... | ['Adrenal Insufficiency', 'Adrenocorticotropic Hormone', 'Adult', 'Calcitriol', 'Corticotropin-Releasing Hormone', 'Diphosphonates', 'Female', 'Glomerulonephritis', 'Humans', 'Hydrocortisone', 'Hypercalcemia', 'Hypoparathyroidism', 'Pamidronate', 'Renal Dialysis'] | 12,900,850 | [['C19.053.500'], ['D06.472.699.327.935.531.500', 'D06.472.699.631.525.600.531.500', 'D12.644.400.400.935.531.500', 'D12.644.548.365.935.531.500', 'D12.644.548.691.525.690.531.500', 'D12.776.631.650.405.935.531.500'], ['M01.060.116'], ['D04.210.500.247.222.159.478.387.300', 'D04.210.500.247.808.146.478.387.300', 'D04.2... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[An experimental study on the therapeutic effects of eustachian tube surfactant in barotitis media]. | OBJECTIVE: To observe the effect of surfactant on eustachian tube (ET) on the opening of ET as well as it's therapeutic role in barotitis media (BM).METHOD: 50 guinea pigs were successfully established as BM models by stimulated ascending in altitude chamber. Parts of the models were treated with by middle ear flushing... | ['Animals', 'Barotrauma', 'Eustachian Tube', 'Female', 'Guinea Pigs', 'Male', 'Otitis Media', 'Surface-Active Agents'] | 15,515,553 | [['B01.050'], ['C26.120'], ['A09.246.397.369'], ['B01.050.150.900.649.313.992.550'], ['C09.218.705.663'], ['D27.720.877']] | ['Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Purification of plasma membrane from Acanthamoeba castellanii. | A simple method for isolation of plasma membrane from Acanthamoeba using self-generating gradients of Percoll is described. To obtain a membrane marker, intact amoebae were radioiodinated and the distribution of the radiolabel was followed through the plasma membrane isolation procedure. The purity of isolated plasma m... | ['Acanthamoeba', 'Actins', 'Animals', 'Cell Fractionation', 'Cell Membrane', 'Centrifugation, Density Gradient', 'Membrane Proteins', 'Microscopy, Electron'] | 3,184,000 | [['B01.046.500.100.075.080'], ['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['B01.050'], ['E05.242.251'], ['A11.284.149'], ['E05.181.724.336', 'E05.196.941.336'], ['D12.776.543'], ['E01.370.350.515.402', 'E05.595.402']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Diagnosis of congenital toxoplasmosis at birth: what is the value of testing for IgM and IgA? | UNLABELLED: Recommendations vary on the best combination of tests to use for the diagnosis of subclinical congenital toxoplasmosis at birth. The diagnostic accuracy of IgM and IgA tests was assessed in the context of routine clinical practice on 233 newborns with congenital toxoplasmosis and 661 healthy controls. IgM/I... | ['Agglutination Tests', 'Female', 'Fetal Blood', 'Humans', 'Immunoglobulin A', 'Immunoglobulin M', 'Infant, Newborn', 'Pregnancy', 'Pregnancy Complications, Infectious', 'Prospective Studies', 'Sensitivity and Specificity', 'Toxoplasmosis, Congenital'] | 10,445,343 | [['E01.370.225.812.735.050', 'E05.200.812.735.050', 'E05.478.594.760.050'], ['A12.207.152.200', 'A15.145.300', 'A16.378.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.486.485.114.619.026', 'D12.776.124.790.651.114.619.026', 'D12.776.377.715.548.114.619.026'], ['D12.776.124.486.485.114.619.574', '... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Studies of IgG-class anticardiolipin antibodies in myasthenia gravis. | IgG-class anticardiolipin antibodies (IgG-ACA) were found in 25% of patients with myasthenia gravis. The prevalence and the level distribution were significantly different from those of a normal donor population (p < 0.001). In myastenic patients, IgG-ACA bound negatively charged, but not zwitterionic, phospholipids. T... | ['Adolescent', 'Adult', 'Aged', 'Antibodies, Anticardiolipin', 'Antibodies, Antinuclear', 'Antibody Specificity', 'Autoantibodies', 'Female', 'Humans', 'Immunoglobulin G', 'Male', 'Middle Aged', 'Myasthenia Gravis', 'Receptors, Cholinergic'] | 7,999,956 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D12.776.124.486.485.114.323.210.100', 'D12.776.124.790.651.114.323.210.100', 'D12.776.377.715.548.114.323.210.100'], ['D12.776.124.486.485.114.323.204', 'D12.776.124.790.651.114.323.204', 'D12.776.377.715.548.114.323.204'], ['G12.100'], ['D12.776.124.486.485.114... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The effects of the inotropic agent EMD 57033 on activation and relaxation kinetics in frog skinned skeletal muscle. | The effect of the cardiotonic sensitizing drug EMD 57033 was studied in frog skinned skeletal muscle fibres at 12 degrees C to provide a baseline for skeletal muscle studies and for comparison with cardiac fibres. The activation and relaxation of fibres were induced by laser flash photolysis of the caged calcium NP-EGT... | ['Animals', 'Cardiotonic Agents', 'Chelating Agents', 'Diazonium Compounds', 'Egtazic Acid', 'Histological Techniques', 'In Vitro Techniques', 'Kinetics', 'Muscle, Skeletal', 'Phenoxyacetates', 'Quinolines', 'Rana temporaria', 'Thiadiazines'] | 11,417,210 | [['B01.050'], ['D27.505.954.411.222', 'D27.720.799.080'], ['D27.505.519.914.500', 'D27.720.832.500'], ['D02.172.383'], ['D02.092.782.258.368.257', 'D02.241.081.018.269'], ['E01.370.225.750', 'E05.200.750'], ['E05.481'], ['G01.374.661', 'G02.111.490'], ['A02.633.567', 'A10.690.552.500'], ['D02.241.081.018.386.682', 'D02... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cutaneous collagenous vasculopathy associated with intravascular occlusive fibrin thrombi. | Cutaneous collagenous vasculopathy (CCV) is a rare cutaneous microangiopathy that clinically resembles generalized essential telangiectasia with only 12 cases reported to date. The perivascular fibrosis is thought to be due to production of abnormal collagen by veil cells in the outer vessel walls as a result of unknow... | ['Aged, 80 and over', 'Fibrin', 'Humans', 'Male', 'Skin', 'Skin Diseases, Vascular', 'Thrombosis', 'Thrombotic Microangiopathies'] | 24,350,781 | [['M01.060.116.100.080'], ['D12.776.124.270'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A17.815'], ['C17.800.862'], ['C14.907.355.830'], ['C15.378.140.855.925']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Assessment of Hurricane Ivan impact on chlorophyll-a in Pensacola Bay by MODIS 250 m remote sensing. | The impact of Hurricane Ivan on water quality in Pensacola Bay was investigated by MODIS 250m remote sensing of chlorophyll-a concentrations at different time slots before and after the hurricane event. Before the hurricane, the mean chlorophyll-a in the Bay was 5.3 ìg/L. Heavy rainfall occurred during the hurricane la... | ['Chlorophyll', 'Chlorophyll A', 'Cyclonic Storms', 'Environment', 'Eutrophication', 'Florida', 'Linear Models', 'Phytoplankton', 'Rain', 'Remote Sensing Technology', 'Water Pollutants, Chemical', 'Water Pollution, Chemical'] | 21,272,900 | [['D03.383.129.578.840.374', 'D03.633.400.909.374', 'D04.345.783.374'], ['D03.383.129.578.840.374.140', 'D03.633.400.909.374.140', 'D04.345.783.374.140'], ['G16.500.175.500', 'N06.230.100.230.100'], ['G16.500.275', 'N06.230'], ['G16.500.285'], ['Z01.107.567.875.750.350'], ['E05.318.740.500.500', 'E05.318.740.750.425', ... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 |
Familial partial monosomy 5p and trisomy 5q; three cases due to paternal pericentric inversion 5 (p151q333). | A family is described in which the mother's 9 pregnancies ended in the birth of 2 healthy girls, 4 spontaneous abortions and 3 infants with multiple congenital malformations as bird-headed appearance, pre- and postnatal growth deficiency, microcephaly, micrognathia with small mouth and cat-like cry. Two of the three af... | ['Adult', 'Child', 'Chromosome Deletion', 'Chromosome Inversion', 'Chromosomes, Human, 4-5', 'Cri-du-Chat Syndrome', 'Dermatoglyphics', 'Female', 'Heart Defects, Congenital', 'Humans', 'Infant', 'Infant, Newborn', 'Karyotyping', 'Lymphocytes', 'Male', 'Pedigree', 'Trisomy'] | 6,478,641 | [['M01.060.116'], ['M01.060.406'], ['C23.550.210.050.500.500', 'G05.365.590.029.530.175', 'G05.365.590.175.050.500.500', 'G05.365.590.762.180', 'G05.558.800.180', 'G05.700.131.500.500'], ['C23.550.210.190', 'G05.365.590.175.190', 'G05.365.590.770.500', 'G05.558.805.500'], ['A11.284.187.520.300.280', 'G05.360.162.520.30... | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
The changing panorama of cerebral palsy in Sweden 1954-1970. II. Analysis of the various syndromes. | From an unselected series of 560 Swedish cases of cerebral palsy, born 1954-1970, various data of etiologic and pathogenetic interest were analyzed in detail. Untraceable and prenatal factors were found to dominate within the group of spastic hemiplegia. Placental dysfunction in small-for-date babies and severe asphyxi... | ['Adolescent', 'Asphyxia Neonatorum', 'Ataxia', 'Athetosis', 'Birth Weight', 'Cerebral Palsy', 'Child', 'Child, Preschool', 'Female', 'Hemiplegia', 'Humans', 'Infant', 'Infant, Newborn', 'Intelligence', 'Movement Disorders', 'Placenta Diseases', 'Pregnancy', 'Quadriplegia', 'Sweden'] | 1,130,175 | [['M01.060.057'], ['C16.614.092'], ['C10.597.350.090', 'C23.888.592.350.090'], ['C10.597.350.110', 'C23.888.592.350.110'], ['C23.888.144.186', 'E01.370.600.115.100.160.120.186', 'E05.041.124.160.750.149', 'G07.100.100.160.120.186', 'G07.345.249.314.120.186'], ['C10.228.140.140.254'], ['M01.060.406'], ['M01.060.406.448'... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Top-down protein identification/characterization of a priori unknown proteins via ion trap collision-induced dissociation and ion/ion reactions in a quadrupole/time-of-flight tandem mass spectrometer. | The identification and characterization of a priori unknown proteins from an Escherichia coli (E. coli) soluble protein lysate using ion trap collision-induced dissociation of intact protein ions followed by ion/ion reactions in a quadrupole/time-of-flight tandem mass spectrometer is illustrated. The procedure involved... | ['Amino Acid Sequence', 'Cell Extracts', 'Complex Mixtures', 'Databases, Protein', 'Escherichia coli', 'Escherichia coli Proteins', 'Molecular Sequence Data', 'Protein Processing, Post-Translational', 'Sensitivity and Specificity', 'Tandem Mass Spectrometry'] | 19,199,571 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D20.777.162'], ['D20'], ['L01.313.500.750.300.188.400.300.750', 'L01.313.500.750.300.188.400.325.710', 'L01.470.750.750.300.750', 'L01.470.750.750.325.710'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D12.776.097.275'], ['L01.453.245.667'], ['G02.111.660.871... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Quantification of peroxynitrite, superoxide, and peroxyl radicals by a new spin trap hydroxylamine 1-hydroxy-2,2,6,6-tetramethyl-4-oxo-piperidine. | The reactions of hydroxylamine 1-hydroxy-2,2,6,6-tetramethyl-4-oxo-piperidine hydrochloride (TEMPONE-H) with peroxynitrite, superoxide and peroxyl radicals were studied. It was shown that under these reactions TEMPONE-H is oxidized into a stable nitroxide 1-hydroxy-2,2,6,6-tetramethyl-4-oxo-piperidi-noxyl (TEMPONE). Th... | ['Amidines', 'Dimethyl Sulfoxide', 'Electron Spin Resonance Spectroscopy', 'Free Radicals', 'Kinetics', 'Molsidomine', 'Nitrates', 'Peroxides', 'Piperidines', 'Reactive Oxygen Species', 'Spin Labels', 'Superoxides', 'Triacetoneamine-N-Oxyl'] | 9,020,059 | [['D02.078'], ['D02.886.640.150'], ['E05.196.867.519.274'], ['D01.339', 'D02.389'], ['G01.374.661', 'G02.111.490'], ['D03.383.129.462.580.693.450', 'D03.383.533.640.362'], ['D01.248.497.158.606', 'D01.625.525.550', 'D02.583'], ['D01.248.497.158.685.750', 'D01.339.431.374', 'D01.650.550.750', 'D02.389.338'], ['D03.383.6... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Host factors that interact with the pestivirus N-terminal protease, Npro, are components of the ribonucleoprotein complex. | UNLABELLED: The viral N-terminal protease N(pro) of pestiviruses counteracts cellular antiviral defenses through inhibition of IRF3. Here we used mass spectrometry to identify a new role for N(pro) through its interaction with over 55 associated proteins, mainly ribosomal proteins and ribonucleoproteins, including RNA ... | ['Animals', 'Diarrhea Virus 1, Bovine Viral', 'Host-Pathogen Interactions', 'Humans', 'Peptide Hydrolases', 'Pestivirus Infections', 'Protein Binding', 'Protein Structure, Tertiary', 'Ribonucleoproteins', 'Ribosomal Proteins', 'Viral Proteins'] | 24,965,446 | [['B01.050'], ['B04.820.578.344.700.150.100'], ['G06.462', 'G16.527.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.277.656'], ['C01.925.782.350.675'], ['G02.111.679', 'G03.808'], ['G02.111.570.820.709.610'], ['D12.776.157.725.500', 'D12.776.664.962.500'], ['D12.776.835'], ['D12.776.964']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Salivary lipid peroxidation and total sialic acid levels during healthy gestation and postpartum: a longitudinal study. | OBJECTIVES: This study investigated salivary lipid peroxidation (LPO) as an oxidative stress marker and salivary total sialic acid (TSA) as an inflammatory response during gestation and postpartum.DESIGN AND METHODS: Salivary LPO and TSA levels, using the Ledwozyw and Warren methods respectively, were obtained in healt... | ['Adult', 'Female', 'Health', 'Humans', 'Lipid Peroxidation', 'Longitudinal Studies', 'N-Acetylneuraminic Acid', 'Postpartum Period', 'Pregnancy', 'Saliva', 'Young Adult'] | 19,896,477 | [['M01.060.116'], ['N01.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.111.515', 'G03.295.531.587'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.750.500', 'N06.850.520.450.500.750.500'], ['D02.241.081.844.562.668.050', 'D02.241.511.902.562.668.050', 'D09.067.687.668.030', 'D09.811.589.668.030'], ['G... | ['Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effect of voluntary respiratory efforts on breath-holding time. | INTRODUCTION: Near the end of a maximal voluntary breath-hold, re-inhalation of the expired gas allows an additional period of breath-holding, indicating that the breaking point does not depend solely on chemical drive. We hypothesized that afferents from respiratory muscle and/or chest wall are significant in breath-h... | ['Adaptation, Physiological', 'Adult', 'Female', 'Humans', 'Male', 'Oxygen Consumption', 'Respiration', 'Respiratory Function Tests', 'Respiratory Muscles', 'Time Factors'] | 17,324,641 | [['G07.025', 'G16.012.500'], ['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G03.680'], ['G09.772.705'], ['E01.370.386.700'], ['A02.633.567.900'], ['G01.910.857']] | ['Phenomena and Processes [G]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The mTOR inhibitor AZD8055 overcomes tamoxifen resistance in breast cancer cells by down-regulating HSPB8. | Tamoxifen, an important endocrine therapeutic agent, is widely used for the treatment of estrogen receptor positive (ER+) breast cancer. However, de novo or acquired resistance prevents patients from benefitting from endocrine approaches and necessitates alternative treatments. In this study, we report that small heat ... | ['Antineoplastic Agents', 'Breast Neoplasms', 'Cell Line, Tumor', 'Down-Regulation', 'Drug Resistance, Neoplasm', 'Estrogen Receptor alpha', 'G1 Phase Cell Cycle Checkpoints', 'Heat-Shock Proteins', 'Humans', 'Molecular Chaperones', 'Morpholines', 'Prognosis', 'Protein Kinase Inhibitors', 'Protein-Serine-Threonine Kina... | 29,345,254 | [['D27.505.954.248'], ['C04.588.180', 'C17.800.090.500'], ['A11.251.210.190', 'A11.251.860.180'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['G07.690.773.984.395'], ['D12.776.826.750.350.174'], ['G04.144.109.249', 'G04.144.500.320.500'], ['D12.776.580.216'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Instillation of continuous tube irrigation in the septic knee at arthroscopy. A technique. | The arthroscope was employed to install a continuous closed tube irrigation system in four septic knees in three patients who had complex medical problems. This simple technique may be accomplished by the orthopedic surgeon with limited arthroscopic expertise. In the open drainage versus closed aspiration dilemma that ... | ['Adult', 'Aged', 'Arthritis, Infectious', 'Arthroscopy', 'Female', 'Humans', 'Knee Joint', 'Male', 'Middle Aged', 'Pseudomonas Infections', 'Staphylococcal Infections', 'Streptococcal Infections', 'Therapeutic Irrigation'] | 6,697,609 | [['M01.060.116'], ['M01.060.116.100'], ['C01.100', 'C05.550.114.099'], ['E01.370.388.250.070', 'E04.502.250.070', 'E04.555.113'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.583.475'], ['M01.060.116.630'], ['C01.150.252.400.739'], ['C01.150.252.410.868'], ['C01.150.252.410.890'], ['E02.779.492.500', 'E02... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Relative frequencies of Alzheimer disease, Lewy body, vascular and frontotemporal dementia, and hippocampal sclerosis in the State of Florida Brain Bank. | Alzheimer disease (AD) is the most common dementing illness in the elderly, but there is equivocal evidence regarding the frequency of other disorders such as Lewy body disease (LBD), vascular dementia (VaD), frontotemporal dementia (FTD), and hippocampal sclerosis (HS). This ambiguity may be related to factors such as... | ['Aged', 'Aged, 80 and over', 'Alzheimer Disease', 'Autopsy', 'Biological Specimen Banks', 'Dementia', 'Dementia, Vascular', 'Female', 'Florida', 'Hippocampus', 'Humans', 'Incidence', 'Lewy Body Disease', 'Male', 'Middle Aged', 'Sclerosis', 'Sex Factors'] | 12,468,894 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['E01.370.060', 'E05.070', 'I01.198.780.937.120'], ['N02.278.065'], ['C10.228.140.380', 'F03.615.400'], ['C10.228.140.300.400', 'C10.228.140.300.510.800.500', 'C10.228.140.380.230', 'C10.228.140.695.500', 'C14.... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Geographicals [Z]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
[Update on the diagnosis and therapy of blood-transmitted occupational infections]. | The Human Immunodeficiency Virus (HIV) infection, Hepatitis B Virus (HBV) infection and Hepatitis C Virus (HCV) infection are the most important blood borne occupational viral infection. Estimates of the prevalence of HIV infection in Italy is between 0.24 and 0.26%. The implementation of HIV screening strategies in th... | ['Blood-Borne Pathogens', 'Communicable Diseases', 'HIV Infections', 'Hepatitis B', 'Hepatitis C', 'Humans', 'Occupational Diseases'] | 21,061,703 | [['B05.155'], ['C01.221', 'C23.550.291.531'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['C01.221.250.500', 'C01.925.256.430.400', 'C01.925.440.435', 'C06.552.380.705.437'], ['C01.221.250.750', 'C01.925.440.440', 'C01.925.782.350.350', 'C... | ['Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Ce6-C6-TPZ co-loaded albumin nanoparticles for synergistic combined PDT-chemotherapy of cancer. | Photodynamic therapy (PDT), as an essential tumor treatment method, has received great attention; however, there are still some challenges such as hydrophobicity of most of the photosensitizers, safety of in vivo transport, and characteristics of oxygen consumption. Herein, we used albumin as the nanocarrier for the lo... | ['Animals', 'Cattle', 'Cell Line, Tumor', 'Cell Survival', 'Coumarins', 'Humans', 'Light', 'Liver', 'Mice', 'Microscopy, Confocal', 'Nanoparticles', 'Neoplasms', 'Photochemotherapy', 'Photosensitizing Agents', 'Porphyrins', 'Serum Albumin, Bovine', 'Thiazoles', 'Tirapazamine', 'Transplantation, Homologous'] | 31,483,422 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.346'], ['D03.383.663.283.446', 'D03.633.100.150.446'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['A03.620'], ['B01.050.150.900.649.31... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Bone marrow declines as a site of B-cell precursor differentiation with age: relationship to thymus involution. | The rearrangement of immunoglobulin genes in B-lymphocyte precursors requires the expression of the recombination activating genes (Rag), which leads to the generation of a highly diverse B-cell repertoire. We can use the level of Rag-1 mRNA in the bone marrow as an index of its capacity to support the maturation of B ... | ['Aging', 'Animals', 'B-Lymphocytes', 'Base Sequence', 'Bone Marrow', 'DNA Primers', 'Female', 'Gene Expression', 'Gene Rearrangement', 'Hematopoietic Stem Cells', 'Homeodomain Proteins', 'Lymphocyte Transfusion', 'Mice', 'Mice, Inbred BALB C', 'Mice, Inbred C57BL', 'Mice, Nude', 'Molecular Sequence Data', 'Polymerase ... | 7,991,570 | [['G07.345.124'], ['B01.050'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A15.382.216'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['G05.297'], ['G05.344'], ['A11.... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[A case of acute cholestatic hepatitis associated with Orlistat]. | Orlistat(Xenical(R), Roche) is considered a safe and effective drug to treat obesity by reduced absorption of 30% digested fat. To date, no serious adverse effects affecting the liver have been published except a case of subacute hepatic failure leading to liver transplantation in a young women with moderate obesity tr... | ['Acute Disease', 'Adult', 'Anti-Obesity Agents', 'Chemical and Drug Induced Liver Injury', 'Cholestasis', 'Female', 'Humans', 'Lactones', 'Lipase', 'Orlistat'] | 12,499,790 | [['C23.550.291.125'], ['M01.060.116'], ['D27.505.954.203'], ['C06.552.100', 'C25.100.562', 'C25.723.260'], ['C06.130.120.135'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.540'], ['D08.811.277.352.100.400'], ['D02.540.529']] | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Disposition of the emerging brominated flame retardant, bis(2-ethylhexyl) tetrabromophthalate, in female Sprague Dawley rats: effects of dose, route and repeated administration. | 1. Bis(2-ethylhexyl)-tetrabromophthalate (BEH-TEBP; CAS No. 26040-51-7; PubChem CID: 117291; MW 706.15 g/mol, elsewhere: TeBrDEPH, TBPH, or BEHTBP) is used as an additive brominated flame retardant in consumer products. 2. Female Sprague Dawley rats eliminated 92-98% of [14C]-BEH-TEBP unchanged in feces after oral admi... | ['Administration, Oral', 'Animals', 'Bile', 'Dose-Response Relationship, Drug', 'Female', 'Flame Retardants', 'Phthalic Acids', 'Rats', 'Rats, Sprague-Dawley', 'Tissue Distribution', 'Toxicity Tests, Chronic'] | 27,098,498 | [['E02.319.267.100'], ['B01.050'], ['A12.200.087'], ['G07.690.773.875', 'G07.690.936.500'], ['D27.720.361'], ['D02.241.223.805'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.750'], ['G03.787.917', 'G07.690.725.949'], ['E05.940.800']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Dimensional change of refractory materials used for ceramic veneers. | The current literature considers a number of clinical factors which affect the fit of all-ceramic laminate veneers. However, little consideration has been given to the refractory die materials, and the laboratory techniques used during the construction of these restorations. This study found a wide range of dimensional... | ['Air', 'Analysis of Variance', 'Dental Casting Investment', 'Dental Marginal Adaptation', 'Dental Porcelain', 'Dental Veneers', 'Phosphates', 'Pressure'] | 12,192,944 | [['G16.500.275.063.150', 'N06.230.300.100.150'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['D25.339.250', 'J01.637.051.339.250'], ['E06.323.764', 'E06.658.224', 'E06.780.620'], ['D25.339.376', 'J01.637.051.339.376', 'J01.637.153.377'], ['E06.780.346.750', 'E07.695.190.196'], ['D01.029.260.700.... | ['Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Back pain management: a patient satisfaction study of services. | The objectives of this study were to assess patient satisfaction with the current services provided for back pain, and to increase the level of understanding from the patients' perspective on beliefs about their back pain and how it affects their daily life. The study was conducted in two parts combining both quantitat... | ['Activities of Daily Living', 'Adaptation, Psychological', 'Back Pain', 'Family Practice', 'Female', 'Focus Groups', 'Humans', 'Male', 'Nursing Methodology Research', 'Patient Satisfaction', 'Physical Therapy Modalities', 'Quality of Health Care', 'Quality of Life', 'Severity of Illness Index', 'Surveys and Questionna... | 11,972,125 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['F01.058'], ['C23.888.592.612.107'], ['H02.403.340.500'], ['E05.318.308.112', 'N05.715.360.300.269', 'N06.850.520.308.112'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H01.770.644.145.390.634', 'H02.478.395.634', 'N04.590.233.508.613.63... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Humanities [K]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 |
Enhanced brain activity preceding voluntary movement in early blind humans. | Effects of blindness on movement-related brain activity were investigated by measuring from the scalp movement-related potentials (MRPs) associated with self-paced button presses in blind and sighted young adults. The blind subjects had lost their vision at an early age due to a deficit in the peripheral visual system.... | ['Adult', 'Blindness', 'Brain', 'Darkness', 'Electroencephalography', 'Evoked Potentials, Motor', 'Evoked Potentials, Visual', 'Female', 'Fingers', 'Higher Nervous Activity', 'Humans', 'Light', 'Male', 'Movement', 'Time Factors'] | 9,792,234 | [['M01.060.116'], ['C10.597.751.941.162', 'C11.966.075', 'C23.888.592.763.941.162'], ['A08.186.211'], ['G01.590.540.233'], ['E01.370.376.300', 'E01.370.405.245'], ['G07.265.216.500.385', 'G11.561.200.500.385'], ['G07.265.216.500.425', 'G11.561.200.500.425', 'G14.330'], ['A01.378.800.667.430'], ['F02.463.247', 'G11.561.... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Integrating social epidemiology into public health research and practice for maternal depression. | The impact of maternal depression on women and their families has been well documented. Given the prevalence and impact of this problem, one important strategy is to strengthen and expand our public health approaches. Although principles of social epidemiology are increasingly used in the field of maternal and child he... | ['Biomedical Research', 'Depression, Postpartum', 'Female', 'Health Promotion', 'Humans', 'Interpersonal Relations', 'Mothers', 'Public Health Practice', 'Social Support'] | 21,493,925 | [['H01.770.644.145'], ['C13.703.844.253', 'F03.600.300.350'], ['I02.233.332.445', 'N02.421.726.407.579'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401'], ['F01.829.263.500.320.200', 'I01.880.853.150.500.340.270', 'M01.620.630'], ['N06.850.780'], ['I01.880.853.500.600']] | ['Disciplines and Occupations [H]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 |
Increased ratio of rapsyn to ACh receptor stabilizes postsynaptic receptors at the mouse neuromuscular synapse. | The metabolic turnover of nicotinic ACh receptors (AChR) at the neuromuscular synapse is regulated over a tenfold range by innervation status, muscle electrical activity and neural agrin, but the downstream effector of such changes has not been defined. The AChR-associated protein rapsyn is essential for forming AChR c... | ['Animals', 'Cells, Cultured', 'Female', 'Metabolic Clearance Rate', 'Mice', 'Mice, Transgenic', 'Muscle Fibers, Skeletal', 'Muscle Proteins', 'Neuromuscular Junction', 'Receptors, Cholinergic', 'Receptors, Neurotransmitter', 'Recombinant Fusion Proteins', 'Recombinant Proteins', 'Tissue Distribution'] | 15,550,459 | [['B01.050'], ['A11.251'], ['E01.370.225.843', 'E05.200.843', 'G03.490', 'G07.690.595', 'G07.690.725.513'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.136.500', 'B01.050.150.900.649.313.992.635.505.500.800'], ['A10.690.552.500.500', 'A11.620.249'], ['D12.776.210.500'], ['A08.800.550.550.550', 'A08.850.5... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The grapefruit flavanone naringin protects against the radiation-induced genomic instability in the mice bone marrow: a micronucleus study. | The effect of various doses, viz. 0, 0.5, 1, 2, 4, 6 and 8 mg/kg body weight of naringin (NIN) (a citrus flavanone) was studied on the alteration in the radiation-induced micronucleated polychromatic (MPCE) and normochromatic (MNCE) erythrocytes in mouse bone marrow exposed to 2 Gy of 60Co gamma-radiation. The treatmen... | ['Animals', 'Antioxidants', 'Bone Marrow', 'DNA Damage', 'Dose-Response Relationship, Radiation', 'Erythrocytes', 'Flavanones', 'Flavonoids', 'Fruit', 'Gamma Rays', 'Male', 'Mice', 'Micronuclei, Chromosome-Defective', 'Radiation-Protective Agents'] | 12,160,890 | [['B01.050'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['A15.382.216'], ['G05.200'], ['E05.799.513.500', 'G01.750.740.500', 'G04.712.500', 'G07.225', 'G07.738.500', 'N06.850.810.250.180'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['D03.383.663.283.266.450.252', 'D03.633.100.150.266.450.2... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Why Public Comments Matter: The Case of the National Institutes of Health Policy on Single Institutional Review Board Review of Multicenter Studies. | PURPOSE: In 2014, the National Institutes of Health (NIH) requested public comments on a draft policy requiring NIH-funded, U.S.-based investigators to use a single institutional review board (sIRB) for ethical review of multicenter studies. The authors conducted a directed content analysis and qualitative summary of t... | ['Ethics Committees, Research', 'Humans', 'Multicenter Studies as Topic', 'National Institutes of Health (U.S.)', 'Policy', 'Policy Making', 'Public Opinion', 'United States'] | 29,517,531 | [['K01.752.566.479.147.750', 'N04.452.758.788.300.750', 'N05.350.268.750', 'N05.700.685.300.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.658', 'N05.715.360.330.643', 'N06.850.520.450.643'], ['I01.409.418.750.600.650.496', 'N03.540.052.750', 'N03.540.348.500.500.600.650.496'], ['I01.655', 'N03.6... | ['Humanities [K]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
The hemodynamic effects of AT-112, an analog of ketanserin, in portal hypertensive rats. | A serotonin mechanism has been reported to contribute to the hyperdynamic circulation of portal hypertension. Different studies have demonstrated that serotonin antagonists decrease portal pressure in portal hypertensive patients and animals. The present study was undertaken to investigate the effect of AT-112, an anal... | ['Animals', 'Antihypertensive Agents', 'Blood Pressure', 'Hemodynamics', 'Hypertension, Portal', 'Male', 'Prazosin', 'Quinazolines', 'Rats', 'Rats, Sprague-Dawley', 'Splanchnic Circulation'] | 9,065,957 | [['B01.050'], ['D27.505.954.411.162'], ['E01.370.600.875.249', 'G09.330.380.076'], ['G09.330.380'], ['C06.552.494'], ['D03.633.100.786.750'], ['D03.633.100.786'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.750'], ['G09.330.100.881']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Clinical evaluation of fiber-reinforced composite inlay FPDs. | PURPOSE: This clinical study evaluated the behavior of inlay fixed partial dentures (IFPD) with conventional and modified framework designs over a period of 12 to 48 months.MATERIALS AND METHODS: Forty-one glass fiber-reinforced composite IFPDs were made to replace one missing maxillary or mandibular tooth. The framewo... | ['Adolescent', 'Adult', 'Cementation', 'Chi-Square Distribution', 'Composite Resins', 'Dental Restoration Failure', 'Denture Design', 'Denture Repair', 'Denture, Partial, Fixed', 'Female', 'Glass', 'Glass Ionomer Cements', 'Humans', 'Inlays', 'Male', 'Middle Aged', 'Odds Ratio', 'Resin Cements', 'Silicate Cement', 'Sta... | 12,854,799 | [['M01.060.057'], ['M01.060.116'], ['E05.170', 'E06.095.170'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['D05.750.716.822.308', 'D25.339.816.500', 'D25.720.716.822.308', 'J01.637.051.339.816.500', 'J01.637.051.720.716.822.308'], ['E06.323.400', 'E06.780.346.725'], ['... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Geochemical distribution, fractionation and contamination assessment of heavy metals in marine sediments of the Asaluyeh port, Persian Gulf. | In this study, total concentration and speciation of heavy metals in sediments of the Asaluyeh, one of the Iran's largest commercial ports, are investigated. 48 sediment samples were collected and analyzed for trace and major elements. Sediment quality guidelines along with calculated enrichment factors and trace metal... | ['Environmental Monitoring', 'Geologic Sediments', 'Indian Ocean', 'Metals, Heavy', 'Water Pollutants, Chemical'] | 28,007,388 | [['N06.850.460.350.080', 'N06.850.780.375'], ['G01.311.330', 'G16.500.320'], ['Z01.756.342'], ['D01.268.556', 'D01.552.544'], ['D27.888.284.903.655']] | ['Health Care [N]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Downregulation of miR-224-5p Promotes Migration and Proliferation in Human Dental Pulp Stem Cells. | Introduction: Pulp regeneration, as a treatment for pulp necrosis, has significant advantages over root canal therapy for the preservation of living pulp. To date, research on pulp regeneration has mainly focused on the transplantation of pulp stem cells into the root canal, but there is still a lack of research on the... | ['Adolescent', 'Adult', 'Cell Movement', 'Cell Proliferation', 'Dental Pulp', 'Down-Regulation', 'Female', 'Humans', 'Male', 'MicroRNAs', 'Stem Cells'] | 31,396,530 | [['M01.060.057'], ['M01.060.116'], ['G04.198', 'G07.568.500.180'], ['G04.161.750', 'G07.345.249.410.750'], ['A14.549.167.900.260'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D13.150.650.319', 'D13.444.735.150.319', 'D13.444.735.790.552.500'], ['A11.872']] | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Osteomalacia in fractures of the proximal femur. | The occurrence of osteomalacia was studied in 58 hip fracture patients who were admitted to the University Central Hospital of Kuopio for operative treatment. Findings indicating osteomalacia were frequent in the series. Hypocalcaemia was found in 70 per cent and an increase in serum alkaline phosphatase in 22 per cent... | ['Aged', 'Alkaline Phosphatase', 'Anthropometry', 'Calcium', 'Female', 'Femoral Neck Fractures', 'Hip Fractures', 'Humans', 'Hydroxycholecalciferols', 'Hypocalcemia', 'Male', 'Middle Aged', 'Osteomalacia', 'Osteoporosis', 'Sex Factors'] | 7,136,573 | [['M01.060.116.100'], ['D08.811.277.352.650.035'], ['E01.370.600.024', 'E05.041', 'N06.850.505.200.100'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['C26.404.061.425.500', 'C26.531.750.500', 'C26.558.276.425.500'], ['C26.404.061.425', 'C26.531.750', 'C26.558.276.425'], ['B01.050.150.900.649.313.988.400.112... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Binaural speech intelligibility in noise for hearing-impaired listeners. | The effect of head-induced interaural time delay (ITD) and interaural level differences (ILD) on binaural speech intelligibility in noise was studied for listeners with symmetrical and asymmetrical sensorineural hearing losses. The material, recorded with a KEMAR manikin in an anechoic room, consisted of speech, presen... | ['Adolescent', 'Adult', 'Female', 'Functional Laterality', 'Hearing Loss, Sensorineural', 'Humans', 'Male', 'Middle Aged', 'Noise', 'Speech Perception'] | 2,808,911 | [['M01.060.057'], ['M01.060.116'], ['F02.830.297.425', 'G11.561.225.425'], ['C09.218.458.341.887', 'C10.597.751.418.341.887', 'C23.888.592.763.393.341.887'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['G01.750.770.776.567', 'G16.500.275.600', 'N06.230.400', 'N06.850.460.610'], ['F02.463.593.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Emergency repair of giant inguinoscrotal hernia in a septic patient. | INTRODUCTION: Giant inguinoscrotal hernias are rare but still exist even in developed countries. Although accompanied by a higher perioperative mortality, an elective surgical approach should be undertaken. In critically ill patients, however, the surgical intervention requires specific demands.METHODS: We report a cas... | ['Emergency Treatment', 'Hernia, Inguinal', 'Herniorrhaphy', 'Humans', 'Male', 'Middle Aged', 'Scrotum', 'Sepsis'] | 23,299,222 | [['E02.365'], ['C23.300.707.374.875'], ['E04.680.325'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['A05.360.444.661'], ['C01.757', 'C23.550.470.790.500']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Comparison of titanium and absorbable polymeric surgical clips for use in laparoscopic cholecystectomy. | The use of hemostatic surgical clips is crucial in laparoscopic surgery. Metal clips can cause significant interference with computerized tomography, may have poor holding power, and may erode into important anatomic structures. Polymeric absorbable clips, which have advantages over metallic clips, are evaluated in thi... | ['Animals', 'Cholecystectomy, Laparoscopic', 'Dogs', 'Hemostasis, Surgical', 'Male', 'Materials Testing', 'Polyglycolic Acid', 'Polymers', 'Rats', 'Sutures', 'Swine', 'Titanium'] | 7,974,100 | [['B01.050'], ['E04.210.120.172.140', 'E04.502.250.520.160'], ['B01.050.150.900.649.313.750.250.216.200'], ['E02.520.490', 'E04.350'], ['E05.570'], ['D05.750.728.780', 'D25.720.728.780', 'J01.637.051.720.728.780'], ['D05.750', 'D25.720', 'J01.637.051.720'], ['B01.050.150.900.649.313.992.635.505.700'], ['E07.858.690.820... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Quality of Recovery After Low-Pressure Laparoscopic Donor Nephrectomy Facilitated by Deep Neuromuscular Blockade: A Randomized Controlled Study. | BACKGROUND: The use of low intra-abdominal pressure (<10 mmHg) reduces postoperative pain scores after laparoscopic surgery.OBJECTIVE: To investigate whether low-pressure pneumoperitoneum with deep neuromuscular blockade improves the quality of recovery after laparoscopic donor nephrectomy (LDN).DESIGN, SETTING AND PAR... | ['Double-Blind Method', 'Female', 'Humans', 'Laparoscopy', 'Male', 'Middle Aged', 'Nephrectomy', 'Neuromuscular Blockade', 'Pain, Postoperative', 'Pneumoperitoneum, Artificial', 'Pressure', 'Surveys and Questionnaires', 'Tissue and Organ Harvesting'] | 28,608,013 | [['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.388.250.520', 'E04.502.250.520'], ['M01.060.116.630'], ['E04.950.774.435'], ['E03.706', 'E05.635'], ['C23.550.767.700', 'C23.888.592.612.832'], ['E01.370.388.605'], ['G01.374... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Modeling amplified p53 responses under DNA-PK inhibition in DNA damage response. | During DNA double strand breaks (DSBs) repair, coordinated activation of phosphatidylinositol 3-kinase (PI3K)-like kinases can activate p53 signaling pathway. Recent findings have identified novel interplays among these kinases demonstrating amplified first p53 pulses under DNA-PK inhibition. However, no theoretical mo... | ['Algorithms', 'Ataxia Telangiectasia Mutated Proteins', 'DNA Damage', 'DNA Repair', 'DNA-Activated Protein Kinase', 'Dose-Response Relationship, Radiation', 'Enzyme Activation', 'Gene Amplification', 'Humans', 'Kinetics', 'Nuclear Proteins', 'Phosphatidylinositol 3-Kinases', 'Phosphorylation', 'Radiation, Ionizing', '... | 28,177,883 | [['G17.035', 'L01.224.050'], ['D08.811.913.696.620.682.700.097', 'D12.776.157.687.125', 'D12.776.660.720.125'], ['G05.200'], ['G02.111.222', 'G05.219'], ['D08.811.913.696.620.682.700.250', 'D12.776.157.687.438', 'D12.776.660.720.438'], ['E05.799.513.500', 'G01.750.740.500', 'G04.712.500', 'G07.225', 'G07.738.500', 'N06... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Initial Experiences of Laparoscopic Gastric Greater Curvature Plication in Korea-A Review of 64 Cases. | PURPOSE: Laparoscopic gastric greater curvature plication (LGGCP) is an emerging, alternative form of restrictive weight loss surgery. We present our experiences of LGGCP with the primary focus on surgical techniques and weight loss. In addition, an investigation was performed on the food tolerance of LGGCP patients.MA... | ['Adult', 'Bariatric Surgery', 'Body Mass Index', 'Eating', 'Esophagitis, Peptic', 'Female', 'Humans', 'Laparoscopy', 'Length of Stay', 'Male', 'Middle Aged', 'Nausea', 'Obesity', 'Patient Satisfaction', 'Republic of Korea', 'Retrospective Studies', 'Stomach', 'Vomiting', 'Weight Loss', 'Young Adult'] | 26,389,582 | [['M01.060.116'], ['E02.650.500.062', 'E04.062'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['G07.203.650.283', 'G10.261.330'], ['C06.405.117.620.420', 'C06.405.205.663.420', 'C06.405.469.275.800.523', 'C06.405.748.586.524'], ['B01.050.150.900.649.313.988.400.112.400.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Two new phenylpropanoid glycosides from the roots of Aruncus sylvester. | Two new phenylpropanoid glycosides, 1,3,4-tri-O-(E)-caffeoyl-â-d-glucopyranoside (1) and 1,4-di-O-(E)-caffeoyl-â-d-glucopyranoside (2), along with four known phenylpropanoid glycosides (3-6), were isolated from the roots of Aruncus sylvester. The structures of 1 and 2 were elucidated using various spectroscopic methods... | ['Antioxidants', 'Biphenyl Compounds', 'Caffeic Acids', 'Drugs, Chinese Herbal', 'Free Radical Scavengers', 'Free Radicals', 'Glucosides', 'Molecular Structure', 'Phenylpropionates', 'Picrates', 'Rosaceae'] | 24,147,759 | [['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['D02.455.426.559.389.185'], ['D02.241.223.200.054'], ['D20.215.784.500.350', 'D26.335'], ['D27.505.519.217.500'], ['D01.339', 'D02.389'], ['D09.408.348'], ['G02.111.570', 'G02.466'], ['D02.241.223.701'], ['D02.455.426.559.389.657.566.690', 'D02.640.743.69... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nkx2.5 enhances the efficacy of mesenchymal stem cells transplantation in treatment heart failure in rats. | AIMS: The aim of this study is to determine whether Nkx2.5 transfection of transplanted bone marrow mesenchymal stem cells (MSCs) improves the efficacy of treatment of adriamycin-induced heart failure in a rat model.MAIN METHODS: Nkx2.5 was transfected in MSCs by lentiviral vector transduction. The expressions of Nkx2.... | ['Animals', 'Blotting, Western', 'Cell Differentiation', 'Disease Models, Animal', 'Doxorubicin', 'Female', 'Gene Expression Regulation', 'Heart Failure', 'Homeobox Protein Nkx-2.5', 'Male', 'Mesenchymal Stem Cell Transplantation', 'Mesenchymal Stem Cells', 'Myocytes, Cardiac', 'Rats', 'Rats, Sprague-Dawley', 'Real-Tim... | 28,624,390 | [['B01.050'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['G04.152'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D02.455.426.559.847.562.050.200.175', 'D04.615.562.050.200.175', 'D09.408.051.059.200.175'], ['G05.308'], ['C14.280.434'], ['D12.776.260.400.23... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Novel sulfated octa- and decasaccharides from squid cartilage chondroitin sulfate E: sequencing and application for determination of the epitope structure of the monoclonal antibody MO-225. | A mixture of octa- and decasaccharides obtained by the digestion with the hyaluronidase of chondroitin sulfate E derived from squid cartilage was subfractionated into 20 and 23 different components, respectively, by anion-exchange HPLC. MALDI-TOF/MS was used to assign the sugar and sulfate composition of the putative o... | ['Animals', 'Antibodies, Monoclonal', 'Cartilage', 'Chondroitin Sulfates', 'Chromatography, Gel', 'Chromatography, High Pressure Liquid', 'Chromatography, Ion Exchange', 'Epitopes', 'Sharks', 'Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization'] | 17,284,053 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['A02.165', 'A10.165.382'], ['D09.698.373.200.300'], ['E05.196.181.400.250'], ['E05.196.181.400.300'], ['E05.196.181.400.383'], ['D23.050.550'], ['B01.050.150.900.493.370.853'], ['E05.196.566.755']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A high-resolution melting approach for analyzing allelic expression dynamics. | Single nucleotide polymorphisms (SNPs) are single base pair mutations that provide new approaches to studies of allele transcript abundances. High-resolution DNA melting curve (HRM) analysis using a LightScanner (Hi-Res Melting system with Idaho's LC Green) provides post-PCR detection of mutations and SNPs in genomic D... | ['Alleles', 'Base Sequence', 'Genes, Plant', 'Molecular Sequence Data', 'Nucleic Acid Denaturation', 'Polymorphism, Single Nucleotide', 'Reverse Transcriptase Polymerase Chain Reaction', 'Solanum tuberosum'] | 19,193,959 | [['G05.360.340.024.340.030'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G05.360.340.024.340.393', 'G05.360.340.365.500'], ['L01.453.245.667'], ['E05.393.640', 'G02.111.603', 'G05.627'], ['G05.365.795.598'], ['E05.393.620.500.725'], ['B01.650.940.800.575.912.250.908.500.725.777']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Impact of anxiety and depressive symptoms on perceptions of stigma in persons living with HIV disease in rural versus urban North Carolina. | This analysis examined the relationships between HIV-related stigma, depression, and anxiety in rural and urban sites. Participants were HIV-positive urban (n = 100) and rural (n = 100) adult residents of a US southern state, drawn from a sample for a larger international study of self-esteem and self-compassion. Measu... | ['Adult', 'Anxiety', 'Depression', 'Empathy', 'Female', 'HIV Infections', 'Humans', 'Male', 'Middle Aged', 'North Carolina', 'Perception', 'Regression Analysis', 'Rural Population', 'Self Concept', 'Social Stigma', 'Socioeconomic Factors', 'Urban Population'] | 26,643,581 | [['M01.060.116'], ['F01.470.132'], ['F01.145.126.350'], ['F01.752.355', 'F01.752.543.500.500'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['Z01.107.567.875.075.475', 'Z... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Extraction of polysaccharides from Phellinus nigricans mycelia and their antioxidant activities in vitro. | In this study, response surface methodology was employed to optimize the extraction of polysaccharides from Phellinus nigricans mycelia. A central composite design was adopted to determine optimum parameters (extraction time, extraction temperature, extraction frequency, and ratio of water to raw material) that could y... | ['Basidiomycota', 'Biphenyl Compounds', 'Factor Analysis, Statistical', 'Free Radical Scavengers', 'Fungal Polysaccharides', 'Hydroxyl Radical', 'Mycelium', 'Picrates', 'Superoxides', 'Temperature', 'Water'] | 24,274,486 | [['B01.300.179'], ['D02.455.426.559.389.185'], ['E05.318.740.400', 'N05.715.360.750.350', 'N06.850.520.830.400'], ['D27.505.519.217.500'], ['D09.698.357', 'D23.050.202.283'], ['D01.045.250.357', 'D01.248.497.158.459.300', 'D01.339.431.249'], ['A19.687'], ['D02.455.426.559.389.657.566.690', 'D02.640.743.690'], ['D01.248... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Wilson disease protein ATP7B is localized in the late endosomes in a polarized human hepatocyte cell line. | Wilson disease is a genetic disorder characterized by the accumulation of copper in the body due to a defect of biliary copper excretion. The gene responsible for Wilson disease has been cloned, however, the precise localization of this gene product ATP7B, a copper-transporting ATPase, is still controversial. We examin... | ['Adenosine Triphosphatases', 'Cation Transport Proteins', 'Cell Line', 'Cell Polarity', 'Chelating Agents', 'Copper', 'Copper Sulfate', 'Copper-Transporting ATPases', 'Endosomes', 'Green Fluorescent Proteins', 'Hepatocytes', 'Humans', 'Luminescent Proteins', 'Mutation', 'Phenanthrolines', 'Recombinant Proteins', 'Tran... | 12,579,329 | [['D08.811.277.040.025'], ['D12.776.157.530.450.250', 'D12.776.543.585.450.250'], ['A11.251.210'], ['G04.250'], ['D27.505.519.914.500', 'D27.720.832.500'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['D01.875.800.800.850.150'], ['D08.811.277.040.025.314.500', 'D12.776.157.530.450.250.578.750', 'D12.776.... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Dose frequency of prostaglandin F2á | We hypothesized (1) that neither duration of the Ovsynch program nor dose frequency of PGF2á would change the proportion of cows with complete luteolysis (progesterone <0.4 ng/mL 72 h after PGF2á) and (2) that the additional GnRH treatment administered as part of a presynchronization program would not alter the proport... | ['Animals', 'Cattle', 'Dinoprost', 'Estrus Synchronization', 'Female', 'Fertility', 'Gonadotropin-Releasing Hormone', 'Insemination, Artificial', 'Lactation', 'Luteolysis', 'Ovulation', 'Pregnancy', 'Progesterone'] | 30,100,501 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['D10.251.355.255.550.400.200', 'D23.469.050.175.725.400.200'], ['E05.820.150.370', 'G08.686.195.500.500'], ['G08.686.210'], ['D06.472.699.327.740.320', 'D12.644.400.400.740.320', 'D12.644.456.460', 'D12.644.548.365.740.320', 'D12.776.631.650.405.740.320'], ['E02.8... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Biological reactive intermediates that mediate chromium (VI) toxicity. | 1. Addition of Cr VI (dichromate) to isolated rat hepatocytes results in rapid glutathione oxidation, reactive oxygen species (ROS) formation, lipid peroxidation, decreased mitochondrial membrane potential and lysosomal membrane rupture before hepatocyte lysis occurred. 2. Cytotoxicity was prevented by "ROS" scavengers... | ['Animals', 'Antioxidants', 'Carcinogens, Environmental', 'Cells, Cultured', 'Chromium', 'Cytochrome P-450 CYP2E1 Inhibitors', 'Glutathione Reductase', 'Hepatocytes', 'Male', 'NAD(P)H Dehydrogenase (Quinone)', 'Rats', 'Rats, Sprague-Dawley', 'Reactive Oxygen Species'] | 11,764,936 | [['B01.050'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['D27.888.569.100.125'], ['A11.251'], ['D01.268.556.175', 'D01.268.956.124', 'D01.552.544.175'], ['D27.505.389.500.421', 'D27.505.519.389.335.421'], ['D08.811.682.667.092'], ['A11.436.348'], ['D08.811.682.608.800.500'], ['B01.050.150.900.649.3... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Transplacental migration of Toxocara canis larvae in experimentally infected mice. | In experimentally infected, nonpregnant mice the larvae of Toxocara canis were not found in the uterus at any time. In mice infected at 1 week, but not at 2 weeks, before gestation, larvae were found in the uterus but not in either the placenta or fetus. In mice infected during pregnancy, larvae were found in the uteru... | ['Animals', 'Ascariasis', 'Female', 'Fetus', 'Liver', 'Maternal-Fetal Exchange', 'Mice', 'Placenta', 'Pregnancy', 'Time Factors', 'Toxocariasis', 'Uterus'] | 932,920 | [['B01.050'], ['C01.610.335.508.700.100.070'], ['A16.378'], ['A03.620'], ['G08.686.784.769.455'], ['B01.050.150.900.649.313.992.635.505.500'], ['A16.710'], ['G08.686.784.769'], ['G01.910.857'], ['C01.610.335.349.868', 'C01.610.335.508.700.100.868', 'C01.610.701.377.868', 'C22.674.377.868'], ['A05.360.319.679']] | ['Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Influence of interimplant distance on gingival papilla formation and bone resorption: clinical-radiographic study in dogs. | PURPOSE: The purpose of this study was to evaluate in dogs the area between implants after prosthetic restoration within 5 mm distance between the contact point (CP) between crowns and the bone crest (BC).MATERIALS AND METHODS: The mandibular premolars of 6 dogs were extracted bilaterally. After 12 weeks of healing, ea... | ['Animals', 'Bone Resorption', 'Dental Implantation, Endosseous', 'Dental Implants', 'Dental Papilla', 'Dental Prosthesis, Implant-Supported', 'Dogs', 'Male', 'Radiography, Dental, Digital'] | 16,519,181 | [['B01.050'], ['C05.116.264', 'G11.427.213.150'], ['E04.545.550.280.280', 'E04.650.230.500', 'E06.645.550.280.280', 'E06.780.314.310'], ['D25.339.312', 'E06.780.346.593', 'E07.695.185', 'J01.637.051.339.312'], ['A14.549.167.900.720.250'], ['E06.780.346.706', 'E07.695.190.185'], ['B01.050.150.900.649.313.750.250.216.200... | ['Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
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This dataset consists of a approx 50k collection of research articles from PubMed repository. Originally these documents are manually annotated by Biomedical Experts with their MeSH labels and each articles are described in terms of 10-15 MeSH labels. In this Dataset we have huge numbers of labels present as a MeSH major which is raising the issue of extremely large output space and severe label sparsity issues. To solve this Issue Dataset has been Processed and mapped to its root as Described in the Below Figure.
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